starting MK-3475 after ipi/Yervoy

I have heard that they are having excellent results with that drug.

In a recent clinical trial, they were having such good results, that they ended the trial early and put the patients receiving the placebo on the drug.

The article was posted here a few weeks ago.

You can have hope and look forward to it working.

Bristol Meyers Suibb has a similar drug Nivolumab that they also had great results with. Especially when used with Yervoy.

best regards

shane

I have heard that they are having excellent results with that drug.

In a recent clinical trial, they were having such good results, that they ended the trial early and put the patients receiving the placebo on the drug.

The article was posted here a few weeks ago.

You can have hope and look forward to it working.

Bristol Meyers Suibb has a similar drug Nivolumab that they also had great results with. Especially when used with Yervoy.

best regards

shane

I have heard that they are having excellent results with that drug.

In a recent clinical trial, they were having such good results, that they ended the trial early and put the patients receiving the placebo on the drug.

The article was posted here a few weeks ago.

You can have hope and look forward to it working.

Bristol Meyers Suibb has a similar drug Nivolumab that they also had great results with. Especially when used with Yervoy.

best regards

shane

Thanks Bubbles for putting the link up to the video. I wish I had your computer skills. Listening to Dr.Ribas speak about how great the future looks for Immunotherapies is very up lifting. I have been on the BMS radomized double blind study of Nivo and Ipi since January). Ed

Thanks Bubbles for putting the link up to the video. I wish I had your computer skills. Listening to Dr.Ribas speak about how great the future looks for Immunotherapies is very up lifting. I have been on the BMS radomized double blind study of Nivo and Ipi since January). Ed

No problem, Ed. It IS uplifting to hear Weber and Ribas speak in those terms!! Good luck in your trial!! C

No problem, Ed. It IS uplifting to hear Weber and Ribas speak in those terms!! Good luck in your trial!! C

No problem, Ed. It IS uplifting to hear Weber and Ribas speak in those terms!! Good luck in your trial!! C

I'm SO sorry that you're going through this. I can totally emphathize. I'm there too, to some degree. My dad was diagnosed with melanoma earlier this year and since then we have all been on a rollercoaster ride of emotions and uncertainty. It totally and completely sucks. BIG HUGS!!!!

I'm SO sorry that you're going through this. I can totally emphathize. I'm there too, to some degree. My dad was diagnosed with melanoma earlier this year and since then we have all been on a rollercoaster ride of emotions and uncertainty. It totally and completely sucks. BIG HUGS!!!!

I'm SO sorry that you're going through this. I can totally emphathize. I'm there too, to some degree. My dad was diagnosed with melanoma earlier this year and since then we have all been on a rollercoaster ride of emotions and uncertainty. It totally and completely sucks. BIG HUGS!!!!

I'm sorry to hear about your mom and can both hear and understand to your frustration.  I've received three different immunotherapies as part of a clinical trial and then standard treatment:  Interleukin-2 (IL-2), TIL, and ipilimumab/Yervoy.  I have not received MK-3475, a.k.a. pembrolizumab, but since you mention Interleukin, wanted to share my experience.

Actually, more important than my own experience is the fact that MK-3475 has been proving far and away to be so much more effective than Interleukin-2 by almost any measure.  That alone should have you focused on it, especially if you are in a position to have your mom eligible to receive it through a trial, EAP, or whatever.

I received Interleukin-2 in 2010-11.  Since I've received subsequent treatments, I'll never know for sure if it's played some role in keeping me here four years later.  It was a tough treatment at the most difficult time of my life, one of the toughest things I've ever done.  I do not regret doing it, and would do it again if I had to.  However, given the opportunity to use an anti-PD-1 like MK-3475 with all that's been learned since then, Interleukin-2 would be way down my list right now.

Joe

I'm sorry to hear about your mom and can both hear and understand to your frustration.  I've received three different immunotherapies as part of a clinical trial and then standard treatment:  Interleukin-2 (IL-2), TIL, and ipilimumab/Yervoy.  I have not received MK-3475, a.k.a. pembrolizumab, but since you mention Interleukin, wanted to share my experience.

Actually, more important than my own experience is the fact that MK-3475 has been proving far and away to be so much more effective than Interleukin-2 by almost any measure.  That alone should have you focused on it, especially if you are in a position to have your mom eligible to receive it through a trial, EAP, or whatever.

I received Interleukin-2 in 2010-11.  Since I've received subsequent treatments, I'll never know for sure if it's played some role in keeping me here four years later.  It was a tough treatment at the most difficult time of my life, one of the toughest things I've ever done.  I do not regret doing it, and would do it again if I had to.  However, given the opportunity to use an anti-PD-1 like MK-3475 with all that's been learned since then, Interleukin-2 would be way down my list right now.

Joe

I'm so very sorry to hear about your mom. I actually just created an account so that I could respond to you. I cannot truly empathize because I'm not yet at that point with my dad, but I can certainly understand your fear and your pain as you watch your mom suffer because that has been my biggest fear since finding out my father's melanoma had metastasized a few weeks ago. 

I'm the only child, and my mom passed away unexpectedly in her sleep about 3.5 years ago, so back home with Dad I moved since losing my mom had left him utterly lost. He also depends on me to make decisions about the best way to proceed, so I do understand what a heavy burden you've carried. Although my mom's death was a complete shock, I pray every night now that my father will be lucky enough to also have such a quick, peaceful death.

One thing I can tell you is that I've spoken many times to an old friend who lost both her parents to cancer within a year of each other. She has promised me that as painful as the process is, we will come out on the other so thankful for being given the opportunity to show our parents such love and comfort during this time. I don't know how I'll be strong enough to do it, but I know that when the time comes, I will be, just as you are now. Another thing she told me is to keep talking and keep laughing. She said that both of her parents laughed right up to the end. 

There isn't much that I can say to offer you comfort. Just know that you aren't alone. I truly am sending you virtual hugs and lots of strength tonight. I hope that it still might be possible for those drugs to kick in and turn things around, but I think you're absolutely right that there must come a point when our hope must be to see the suffering end. Take care of your dad as well. I never quite  managed to stay married, but I know from my own father's experience that losing a life partner is incredibly difficult, particularly for men.

Just do the best you can. I'll keep you in my thoughts.

Elaine

I'm so very sorry to hear about your mom. I actually just created an account so that I could respond to you. I cannot truly empathize because I'm not yet at that point with my dad, but I can certainly understand your fear and your pain as you watch your mom suffer because that has been my biggest fear since finding out my father's melanoma had metastasized a few weeks ago. 

I'm the only child, and my mom passed away unexpectedly in her sleep about 3.5 years ago, so back home with Dad I moved since losing my mom had left him utterly lost. He also depends on me to make decisions about the best way to proceed, so I do understand what a heavy burden you've carried. Although my mom's death was a complete shock, I pray every night now that my father will be lucky enough to also have such a quick, peaceful death.

One thing I can tell you is that I've spoken many times to an old friend who lost both her parents to cancer within a year of each other. She has promised me that as painful as the process is, we will come out on the other so thankful for being given the opportunity to show our parents such love and comfort during this time. I don't know how I'll be strong enough to do it, but I know that when the time comes, I will be, just as you are now. Another thing she told me is to keep talking and keep laughing. She said that both of her parents laughed right up to the end. 

There isn't much that I can say to offer you comfort. Just know that you aren't alone. I truly am sending you virtual hugs and lots of strength tonight. I hope that it still might be possible for those drugs to kick in and turn things around, but I think you're absolutely right that there must come a point when our hope must be to see the suffering end. Take care of your dad as well. I never quite  managed to stay married, but I know from my own father's experience that losing a life partner is incredibly difficult, particularly for men.

Just do the best you can. I'll keep you in my thoughts.

Elaine

I'm so very sorry to hear about your mom. I actually just created an account so that I could respond to you. I cannot truly empathize because I'm not yet at that point with my dad, but I can certainly understand your fear and your pain as you watch your mom suffer because that has been my biggest fear since finding out my father's melanoma had metastasized a few weeks ago. 

I'm the only child, and my mom passed away unexpectedly in her sleep about 3.5 years ago, so back home with Dad I moved since losing my mom had left him utterly lost. He also depends on me to make decisions about the best way to proceed, so I do understand what a heavy burden you've carried. Although my mom's death was a complete shock, I pray every night now that my father will be lucky enough to also have such a quick, peaceful death.

One thing I can tell you is that I've spoken many times to an old friend who lost both her parents to cancer within a year of each other. She has promised me that as painful as the process is, we will come out on the other so thankful for being given the opportunity to show our parents such love and comfort during this time. I don't know how I'll be strong enough to do it, but I know that when the time comes, I will be, just as you are now. Another thing she told me is to keep talking and keep laughing. She said that both of her parents laughed right up to the end. 

There isn't much that I can say to offer you comfort. Just know that you aren't alone. I truly am sending you virtual hugs and lots of strength tonight. I hope that it still might be possible for those drugs to kick in and turn things around, but I think you're absolutely right that there must come a point when our hope must be to see the suffering end. Take care of your dad as well. I never quite  managed to stay married, but I know from my own father's experience that losing a life partner is incredibly difficult, particularly for men.

Just do the best you can. I'll keep you in my thoughts.

Elaine

I'm sorry to hear about your mom and can both hear and understand to your frustration.  I've received three different immunotherapies as part of a clinical trial and then standard treatment:  Interleukin-2 (IL-2), TIL, and ipilimumab/Yervoy.  I have not received MK-3475, a.k.a. pembrolizumab, but since you mention Interleukin, wanted to share my experience.

Actually, more important than my own experience is the fact that MK-3475 has been proving far and away to be so much more effective than Interleukin-2 by almost any measure.  That alone should have you focused on it, especially if you are in a position to have your mom eligible to receive it through a trial, EAP, or whatever.

I received Interleukin-2 in 2010-11.  Since I've received subsequent treatments, I'll never know for sure if it's played some role in keeping me here four years later.  It was a tough treatment at the most difficult time of my life, one of the toughest things I've ever done.  I do not regret doing it, and would do it again if I had to.  However, given the opportunity to use an anti-PD-1 like MK-3475 with all that's been learned since then, Interleukin-2 would be way down my list right now.

Joe

Thanks Bubbles for putting the link up to the video. I wish I had your computer skills. Listening to Dr.Ribas speak about how great the future looks for Immunotherapies is very up lifting. I have been on the BMS radomized double blind study of Nivo and Ipi since January). Ed