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Sequential nivo then ipi = ORR of 41%. Ipi then nivo = 20%!!!

Forums General Melanoma Community Sequential nivo then ipi = ORR of 41%. Ipi then nivo = 20%!!!

  • Post
    Bubbles
    Participant

      As Weber alluded to in the webinar included in my last post…the synopsis thus far, of the CheckMate 064 trial with sequential Ipi followed by Nivo vs Nivo followed by Ipi was put out today at the 2015 European Cancer Congress.

      Here is a post I put up that includes the abstract as well as a link to a report from OncLive. http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/09/sequential-nivo-then-ipi-orr-of-41-ipi.html
       
      All I can say is….Here's to the ratties.  We owe you a debt of gratitude that we will never be able to repay.
       
      And……FDA…..Are you listening???????
       
      My best to you all.  Celeste
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    • Replies
        katie1
        Participant

          Thanks as always for your posts!  Your work is very much appreciated!

          Kate

          katie1
          Participant

            Thanks as always for your posts!  Your work is very much appreciated!

            Kate

            katie1
            Participant

              Thanks as always for your posts!  Your work is very much appreciated!

              Kate

              ET-SF
              Participant

                Impressive!  This finding bears replication, of course, but it certainly says a lot about the FDA-sanctioned standards of treatment (ipi first).

                My first thought is that I wonder how these results would compare to nivo alone.  I suspect the nivo-first advantage relates to getting the more effective drug sooner, when it can do more good.  Just a hunch.

                  Bubbles
                  Participant

                    Nivo alone has a 40-45% response rate…slightly higher in PD-L1 positive patients. The post I put up addressing combination therapies breaks it all down. C

                    Bubbles
                    Participant

                      Nivo alone has a 40-45% response rate…slightly higher in PD-L1 positive patients. The post I put up addressing combination therapies breaks it all down. C

                      Bubbles
                      Participant

                        Nivo alone has a 40-45% response rate…slightly higher in PD-L1 positive patients. The post I put up addressing combination therapies breaks it all down. C

                      ET-SF
                      Participant

                        Impressive!  This finding bears replication, of course, but it certainly says a lot about the FDA-sanctioned standards of treatment (ipi first).

                        My first thought is that I wonder how these results would compare to nivo alone.  I suspect the nivo-first advantage relates to getting the more effective drug sooner, when it can do more good.  Just a hunch.

                        ET-SF
                        Participant

                          Impressive!  This finding bears replication, of course, but it certainly says a lot about the FDA-sanctioned standards of treatment (ipi first).

                          My first thought is that I wonder how these results would compare to nivo alone.  I suspect the nivo-first advantage relates to getting the more effective drug sooner, when it can do more good.  Just a hunch.

                          ed williams
                          Participant

                            Thanks for posting Celeste!!! This was a phase 2 trial of 160 patients which means a larger phase 3 trial will follow!!! The one thing that Melanoma continues to produce is ratties for big pharma Celeste, for at least the near future. My "mouse" study (checkmate 67) ends for me in January 2016 and I am sure that the data will support using Nivolumab first and the Nivo/Ipi combo as the standand for those who are healthy enough to tolerate the higher % chance of side effects that comes with the combo. Take care Ed!!!

                            ed williams
                            Participant

                              Thanks for posting Celeste!!! This was a phase 2 trial of 160 patients which means a larger phase 3 trial will follow!!! The one thing that Melanoma continues to produce is ratties for big pharma Celeste, for at least the near future. My "mouse" study (checkmate 67) ends for me in January 2016 and I am sure that the data will support using Nivolumab first and the Nivo/Ipi combo as the standand for those who are healthy enough to tolerate the higher % chance of side effects that comes with the combo. Take care Ed!!!

                              ed williams
                              Participant

                                Thanks for posting Celeste!!! This was a phase 2 trial of 160 patients which means a larger phase 3 trial will follow!!! The one thing that Melanoma continues to produce is ratties for big pharma Celeste, for at least the near future. My "mouse" study (checkmate 67) ends for me in January 2016 and I am sure that the data will support using Nivolumab first and the Nivo/Ipi combo as the standand for those who are healthy enough to tolerate the higher % chance of side effects that comes with the combo. Take care Ed!!!

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