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Scientists Made Step Forward In Melanoma Threating
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Scientists Made Step Forward In Melanoma Threating

› Forums › General Melanoma Community › Scientists Made Step Forward In Melanoma Threating

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    • January 6, 2018 at 6:58 pm
    edward989
    Participant

      Recently, the newest study made a step forward in treating Melanoma with use of treatment called anti-PD-1 therapy. It is a threatment that uses TNF-alpha protein, which rases anti-tumour immune responses in samples of human melanoma.

      Best,

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        • January 6, 2018 at 7:11 pm
        ed williams
        Participant

          Kind of curious about the article? Would be nice to have names of people who are doing the research! Article doesn't seem to have any sources to the actual research, do you have any?

            • January 6, 2018 at 7:29 pm
            ed williams
            Participant

              I think the article is based on this mouse model study. https://www.nature.com/articles/s41467-017-02358-7

              • January 6, 2018 at 8:05 pm
              lou2
              Participant

                The references give names.  Also, here is a report from Science journal on this work.  Do search for full text by using the journal name etc at the bottom.

                 

                Taking aim at regulatory T cells
                Leslie K. Ferrarelli
                Cancer immunotherapy attempts to stimulate the patient's immune system against a tumor, but it can be limited by the suppressive effects of the patient's own regulatory T (Treg) cells. Nie et al. showed that coinhibiting a TNF (tumor necrosis factor) receptor reduced Treg cell activity and proliferation, stimulated antitumor immune memory, and even shrank colon and breast tumors in mice that were unresponsive to common single-agent immunotherapies. Thus, adding anti-TNF therapeutics may help to increase and broaden the efficacy of immunotherapy for cancer patients.

                Sci. Signal. 10, eaan0790 (2018

                • January 6, 2018 at 8:08 pm
                lou2
                Participant
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