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Roche/Plexxikon BRAF (PLX 4032) Compassionate Use

Forums General Melanoma Community Roche/Plexxikon BRAF (PLX 4032) Compassionate Use

  • Post
    mrf
    Keymaster

    This drug has had a lot of press over the past several months, based on strong results from a small, early trial.  Today the data for larger trial were released, and here are the key points: 

    –this drug is used only for melanoma patients who have mutated BRAF, about half of all melanoma patients

    –about 53% of people who receive this drug have a response to the drug (vs. 14% for IL-2, for example)

    –average duration of response is between 6 and 7 months

    This drug has had a lot of press over the past several months, based on strong results from a small, early trial.  Today the data for larger trial were released, and here are the key points: 

    –this drug is used only for melanoma patients who have mutated BRAF, about half of all melanoma patients

    –about 53% of people who receive this drug have a response to the drug (vs. 14% for IL-2, for example)

    –average duration of response is between 6 and 7 months

    I learned today that the company is moving forward with an expanded access, or compassionate use program.  And here is the news:  they anticipate having this program open by the end of 2011.

    This is much faster than I thought would happen, and is good news for people interested in having access to this drug.

    I will know more as this develops, and will try to keep everyone updated.

     

    Tim–MRF

     

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  • Replies
      King
      Participant

      Thanks for the information, Tim.   I sure appreciate it.

       

      Stay Strong
      King

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      King
      Participant

      Thanks for the information, Tim.   I sure appreciate it.

       

      Stay Strong
      King

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      sharmon
      Participant

      Thanks for the update.  I sure hope you meant to say end of 2010.

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      sharmon
      Participant

      Thanks for the update.  I sure hope you meant to say end of 2010.

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        glewis923
        Participant

        ….I hope he meant end of 2010 also,  but I'm afraid he got it right by saying "…end of 2011".    It's a shame.  

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        glewis923
        Participant

        ….I hope he meant end of 2010 also,  but I'm afraid he got it right by saying "…end of 2011".    It's a shame.  

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      sharmon
      Participant

      Thanks for the update.  I sure hope you meant to say end of 2010.

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      sharmon
      Participant

      Thanks for the update.  I sure hope you meant to say end of 2010.

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      W.
      Participant

      I have read on another site that "Twenty U.S. Centers will open by the end of December 2010".

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      W.
      Participant

      I have read on another site that "Twenty U.S. Centers will open by the end of December 2010".

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      Suzan AB
      Participant

      Hi Tim,

      Question…Does average response time mean time in remission?  Does it mean that you are NED for 6-7 months before having mets show up again?  Please advise.

      Suzan AB

      Stage IV

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      Suzan AB
      Participant

      Hi Tim,

      Question…Does average response time mean time in remission?  Does it mean that you are NED for 6-7 months before having mets show up again?  Please advise.

      Suzan AB

      Stage IV

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        W.
        Participant

        Suzan,

        I'm not Tim, but to answer the question: You are right.

        More precisely: "The time to relapse or progression is the duration of response."

        http://www.cancerhelp.org.uk/trials/taking-part/what-do-the-results-mean#duration

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        W.
        Participant

        Suzan,

        I'm not Tim, but to answer the question: You are right.

        More precisely: "The time to relapse or progression is the duration of response."

        http://www.cancerhelp.org.uk/trials/taking-part/what-do-the-results-mean#duration

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        Suzan AB
        Participant

        Thank you for your response and link.  This give me more information so I can choose the right option…quality vs. quanity, suffering of family and friends vs. lenth of life…food for thought.  Don't get me wrong…I am a fighter!  Knowledge = Power = Choice!  Thanks again for answering my question.

        Biggest of Hugs…Off to go fishing…Hubby is in the fun mode!  Whoopee going to catch a big one today!

        Suzan AB

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        Suzan AB
        Participant

        Thank you for your response and link.  This give me more information so I can choose the right option…quality vs. quanity, suffering of family and friends vs. lenth of life…food for thought.  Don't get me wrong…I am a fighter!  Knowledge = Power = Choice!  Thanks again for answering my question.

        Biggest of Hugs…Off to go fishing…Hubby is in the fun mode!  Whoopee going to catch a big one today!

        Suzan AB

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      killmel
      Participant

      Tim,

       

      It would be helpful after going to this link:

      http://forum.melanomaintl.org/toastforums/toast.asp?sub=show&action=posts&fid=4&tid=17319

       

      If you could giveus more info. about PLX4032 expanded access.

       

      Thanks

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      killmel
      Participant

      Tim,

       

      It would be helpful after going to this link:

      http://forum.melanomaintl.org/toastforums/toast.asp?sub=show&action=posts&fid=4&tid=17319

       

      If you could giveus more info. about PLX4032 expanded access.

       

      Thanks

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      Jan in OC
      Participant

      I am glad that more people will have access to this.  My husband has been on the Roche BRAF trial at UCLA since mid-Feb 2010.  We see tiny reductions in size of his mets every 2 months on the CT scans and no new mets developing.  The drug is not fast acting for us and we "whine" about the side effects, but we are really grateful that my husband is still here to celebrate another Birthday/Thanksgiving/Christmas!  Our Dr says sometimes slow is better on this drug.  My husband had a MRI of the brain last week and it is all clear, so we continue on the trial……

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      Jan in OC
      Participant

      I am glad that more people will have access to this.  My husband has been on the Roche BRAF trial at UCLA since mid-Feb 2010.  We see tiny reductions in size of his mets every 2 months on the CT scans and no new mets developing.  The drug is not fast acting for us and we "whine" about the side effects, but we are really grateful that my husband is still here to celebrate another Birthday/Thanksgiving/Christmas!  Our Dr says sometimes slow is better on this drug.  My husband had a MRI of the brain last week and it is all clear, so we continue on the trial……

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