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Roche/Plexxikon BRAF (PLX 4032) Compassionate Use

Forums General Melanoma Community Roche/Plexxikon BRAF (PLX 4032) Compassionate Use

  • Post
    mrf
    Keymaster

      This drug has had a lot of press over the past several months, based on strong results from a small, early trial.  Today the data for larger trial were released, and here are the key points: 

      –this drug is used only for melanoma patients who have mutated BRAF, about half of all melanoma patients

      –about 53% of people who receive this drug have a response to the drug (vs. 14% for IL-2, for example)

      –average duration of response is between 6 and 7 months

      This drug has had a lot of press over the past several months, based on strong results from a small, early trial.  Today the data for larger trial were released, and here are the key points: 

      –this drug is used only for melanoma patients who have mutated BRAF, about half of all melanoma patients

      –about 53% of people who receive this drug have a response to the drug (vs. 14% for IL-2, for example)

      –average duration of response is between 6 and 7 months

      I learned today that the company is moving forward with an expanded access, or compassionate use program.  And here is the news:  they anticipate having this program open by the end of 2011.

      This is much faster than I thought would happen, and is good news for people interested in having access to this drug.

      I will know more as this develops, and will try to keep everyone updated.

       

      Tim–MRF

       

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    • Replies
        King
        Participant

          Thanks for the information, Tim.   I sure appreciate it.

           

          Stay Strong
          King

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          King
          Participant

            Thanks for the information, Tim.   I sure appreciate it.

             

            Stay Strong
            King

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            sharmon
            Participant

              Thanks for the update.  I sure hope you meant to say end of 2010.

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              sharmon
              Participant

                Thanks for the update.  I sure hope you meant to say end of 2010.

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                  glewis923
                  Participant

                    ….I hope he meant end of 2010 also,  but I'm afraid he got it right by saying "…end of 2011".    It's a shame.  

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                    glewis923
                    Participant

                      ….I hope he meant end of 2010 also,  but I'm afraid he got it right by saying "…end of 2011".    It's a shame.  

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                    sharmon
                    Participant

                      Thanks for the update.  I sure hope you meant to say end of 2010.

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                      sharmon
                      Participant

                        Thanks for the update.  I sure hope you meant to say end of 2010.

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                        W.
                        Participant

                          I have read on another site that "Twenty U.S. Centers will open by the end of December 2010".

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                          W.
                          Participant

                            I have read on another site that "Twenty U.S. Centers will open by the end of December 2010".

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                            Suzan AB
                            Participant

                              Hi Tim,

                              Question…Does average response time mean time in remission?  Does it mean that you are NED for 6-7 months before having mets show up again?  Please advise.

                              Suzan AB

                              Stage IV

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                              Suzan AB
                              Participant

                                Hi Tim,

                                Question…Does average response time mean time in remission?  Does it mean that you are NED for 6-7 months before having mets show up again?  Please advise.

                                Suzan AB

                                Stage IV

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                                  W.
                                  Participant

                                    Suzan,

                                    I'm not Tim, but to answer the question: You are right.

                                    More precisely: "The time to relapse or progression is the duration of response."

                                    http://www.cancerhelp.org.uk/trials/taking-part/what-do-the-results-mean#duration

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                                    W.
                                    Participant

                                      Suzan,

                                      I'm not Tim, but to answer the question: You are right.

                                      More precisely: "The time to relapse or progression is the duration of response."

                                      http://www.cancerhelp.org.uk/trials/taking-part/what-do-the-results-mean#duration

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                                      Suzan AB
                                      Participant

                                        Thank you for your response and link.  This give me more information so I can choose the right option…quality vs. quanity, suffering of family and friends vs. lenth of life…food for thought.  Don't get me wrong…I am a fighter!  Knowledge = Power = Choice!  Thanks again for answering my question.

                                        Biggest of Hugs…Off to go fishing…Hubby is in the fun mode!  Whoopee going to catch a big one today!

                                        Suzan AB

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                                        Suzan AB
                                        Participant

                                          Thank you for your response and link.  This give me more information so I can choose the right option…quality vs. quanity, suffering of family and friends vs. lenth of life…food for thought.  Don't get me wrong…I am a fighter!  Knowledge = Power = Choice!  Thanks again for answering my question.

                                          Biggest of Hugs…Off to go fishing…Hubby is in the fun mode!  Whoopee going to catch a big one today!

                                          Suzan AB

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                                        killmel
                                        Participant

                                          Tim,

                                           

                                          It would be helpful after going to this link:

                                          http://forum.melanomaintl.org/toastforums/toast.asp?sub=show&action=posts&fid=4&tid=17319

                                           

                                          If you could giveus more info. about PLX4032 expanded access.

                                           

                                          Thanks

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                                          killmel
                                          Participant

                                            Tim,

                                             

                                            It would be helpful after going to this link:

                                            http://forum.melanomaintl.org/toastforums/toast.asp?sub=show&action=posts&fid=4&tid=17319

                                             

                                            If you could giveus more info. about PLX4032 expanded access.

                                             

                                            Thanks

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                                            Jan in OC
                                            Participant

                                              I am glad that more people will have access to this.  My husband has been on the Roche BRAF trial at UCLA since mid-Feb 2010.  We see tiny reductions in size of his mets every 2 months on the CT scans and no new mets developing.  The drug is not fast acting for us and we "whine" about the side effects, but we are really grateful that my husband is still here to celebrate another Birthday/Thanksgiving/Christmas!  Our Dr says sometimes slow is better on this drug.  My husband had a MRI of the brain last week and it is all clear, so we continue on the trial……

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                                              Jan in OC
                                              Participant

                                                I am glad that more people will have access to this.  My husband has been on the Roche BRAF trial at UCLA since mid-Feb 2010.  We see tiny reductions in size of his mets every 2 months on the CT scans and no new mets developing.  The drug is not fast acting for us and we "whine" about the side effects, but we are really grateful that my husband is still here to celebrate another Birthday/Thanksgiving/Christmas!  Our Dr says sometimes slow is better on this drug.  My husband had a MRI of the brain last week and it is all clear, so we continue on the trial……

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