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Relapse of melanoma after successful adoptive T-cell therapy
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Relapse of melanoma after successful adoptive T-cell therapy

› Forums › General Melanoma Community › Relapse of melanoma after successful adoptive T-cell therapy

  • Post
    • August 8, 2013 at 1:10 pm
    JerryfromFauq
    Participant

      http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12038/full

      http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12038/full

      The results of Landsberg et al. have important clinical implications if the phenotypic plasticity of melanoma cells in an inflammatory microenvironment is validated in a larger cohort of patients with melanoma after ACT. Down-modulation of gp100 expression and concurrent up-regulation of NGFR expression of melanoma cells in an inflammatory environment raises the possibility of using ACT with a cocktail of CAR-engineered T cells with dual or multiple specificities to target more than one melanoma antigen to ensure complete regression of tumor lesions. For this, a personalized approach of analyzing melanoma antigen expression on tumor cells before and after ACT therapy will be essential for the selection of CAR-engineered T cells with defined tumor antigen specificity. The proposed approach may enhance the long term disease-free survival of patients with metastatic melanoma.

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      INTERESTING.  My question, "would aspirin improve the ACT/TIL success"? 

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    • Replies
        • August 8, 2013 at 1:49 pm
        benp
        Participant
          Very interesting, thanks for posting.
          • August 8, 2013 at 1:49 pm
          benp
          Participant
            Very interesting, thanks for posting.
            • August 8, 2013 at 1:49 pm
            benp
            Participant
              Very interesting, thanks for posting.
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