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POG – Personalized Oncogenomics
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POG – Personalized Oncogenomics

› Forums › General Melanoma Community › POG – Personalized Oncogenomics

  • Post
    • October 26, 2018 at 5:45 pm
    GeoTony
    Participant

      Hi all, its been a while, so I'm still on the Nivo maintenance and everything's stable, so no complaints there. However I've been offered a place on British Columbia's POG research program, basically they run a DNA/RNA profile on my blood and on a tumour sample, compare the two and look for anomalies. This then allows them to recomend existing cancer treatments and non-cancer drugs that target cancer pathways, the coordinator presented a way more technical description of the process and I'm still digesting the 18 page consent form. Trial # NCT02155621 if you're interested in the technical detail

      My question is does anyone on the board have experience of DNA profiling to guide treatment?

      Thanks

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    • Replies
        • October 26, 2018 at 9:42 pm
        Julie in SoCal
        Participant

          Hi Tony,

          My Rock Star Doc and I talked about this the last time I saw him. I've probably had too much prior treatment for melanoma,  but I may qualify for non-small cell lung cancer.  

          I've reciently had a lot of medical stuff and I'd hoped to take a bit of a break, so I declined it for now.  Maybe next time.

          Wishing you all the best with the POG Trial!

          Shalom,

          Julie

          • October 29, 2018 at 8:06 am
          CindyJ
          Participant

            Hi Tony, yes my mother is in this trial study https://clinicaltrials.gov/ct2/show/record/NCT02693535?term=Targeted+agent+and+profiling+utilization+registry&cntry=US&rank=1

            They did a genomic test on her tumor early last year after immunotherapy failed, which provided two specific mutations. One is CCND1 amplification. They put her on a breast cancer drug, Ibrance, which blocks that growth. She has been on it for a year and a half and though her tumor burden was low to begin with, she went NED six months ago. We did have a scare this last PET but it turned out a new lung nodule is pneumonia related.

            Her oncologist is one of the doctors in charge of this study in the Salt Lake area. He really believes this is the future. Good luck with whatever you decide!

              • October 30, 2018 at 5:37 am
              GeoTony
              Participant

                Hi CindyJ, thanks for your reply, I'm currently stable with Nivo maintenance, due to end next March. However the option of genomic profiling and possible identification of a treatable cancer pathway is too good to miss. The more information, the better prepared for the future, with melanoma it changes with each scan. Good to hear your mother is NED, long may that last, Tony

                • October 30, 2018 at 10:55 am
                CindyJ
                Participant

                  Thanks Tony! And so glad you are stable!! I agree, finding out your specific mutation(s) is something you can keep in your back pocket if needed down the road. Let us know what they find. Not sure if my mother and I stumbled into the perfect storm, but in our experience, it seems this is the way cancer should be treated instead of a one shop deal. Fingers crossed for you in the future!

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