Pembrolizumab + Lenvatinib
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Pembrolizumab + Lenvatinib

› Forums › General Melanoma Community › Pembrolizumab + Lenvatinib

  • Post
    • September 17, 2020 at 6:47 pm
    Juan Arias
    Participant
    Dear Fighters,

    STAGE 4 from Dec-2019. After 10 months of TAF/MEK treatment (Targeted Therapy) with good results, due to some progression in brain, I must to change to Pembro (Immunotherapy). I have a chance to get in clinical trial with Pembio + Lenvatinib. In this trial I have 50% chance of take Lenvatinib drug.

    Is there someone participating in this clinical trial? Can you share me your experience?
    I just see one post talking about Lenva, published last year.

    Kind reagards,

    JayA

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  • Replies
      • September 18, 2020 at 9:02 pm
      Linda5
      Participant
      Hi Jay,
      I have been on the leap-004 trial of pembro and Lenvatinib for 15 months (definitely on the Lenvatinib). I’ve had some progression that we’ve managed with radiation but generally it has kept things under control. It’s a tough trial though, lots of blood pressure issues, they watch your cardiac status closely, have some neuropathy, currently having some liver enzyme issues. Tired most of the time, nausea for several months now. From what I hear, there are a few on the trial (I’m in Toronto) and sounds like the results are pretty reasonable across the board, but it’s been a tough slog.

      Hope his helps!
      Linda

        • September 19, 2020 at 3:31 am
        Mark_DC
        Participant
        Dear Jay and Linda, I just found this post tonight on twitter about this trial

        It posts to a more detailed study with response rates
        It seems that they think it makes a difference for those who progressed on anti PD1, they are getting some responses
        Hope this helps
        Mark

        • September 19, 2020 at 12:11 pm
        Linda5
        Participant
        Thank you Mark!
        • September 19, 2020 at 12:28 pm
        Juan Arias
        Participant
        Thank you Linda and Mark.
        • September 19, 2020 at 7:53 pm
        Mark_DC
        Participant

        Jason Luke posted this link on twitter too on study results at ESMO
        For me they are too hard to understand – my intuition is that they are seeing some benefits, and that this is a good result given earlier progression on PD1
        Probably best to discuss with your oncologist, or for experts here to chip in. Or maybe they will summarize later in an onclive video

        • September 19, 2020 at 7:53 pm
        Mark_DC
        Participant

        Jason Luke posted this link on twitter too on study results at ESMO
        For me they are too hard to understand – my intuition is that they are seeing some benefits, and that this is a good result given earlier progression on PD1
        Probably best to discuss with your oncologist, or for experts here to chip in. Or maybe they will summarize later in an onclive video

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