PD1L positive vs PD1L negative

This topic has 5 replies, 3 voices, and was last updated 4 years, 7 months ago by caman.

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- April 29, 2020 at 3:49 pm
- Quote
caman
Participant
Hi fellow warriors,

Just finished my first month on Keytruda, and results are real good. The tumor on my neck shrunk significantly, there’s hardly anything left of that little animal.

But I been reading about on PDL1 expression and its use as a prognostic indicator. 50 percent and above is a real good indicator immunotherapy will be effective and the prognosis is much better.

Mine was 5 percent. My doctor said that’s good enough. He also said depending when the expression was taken, before immunotherapy or after, the percentage would be different. If done after, the percentage would be higher. Mines was taken before. Anyone else here have any experience with this you can share? Thank you!

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- - April 29, 2020 at 5:15 pm
  - Quote
  Bubbles
  Participant
  Here are some research articles on PD-L1 and response if you are interested:
  
  From 2015: https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/07/pd-l1-positive-which-immunotherapy-is.html
  
  2016 – with some good charts: https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/09/dr-daud-reviews-asco-2016-immunology.html
  
  2018: https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2018/05/in-melanoma-if-you-are-worried-about.html
  
  2019: https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2019/06/why-doesnt-immunotherapy-work-for-all.html
  
  c
- - April 29, 2020 at 6:14 pm
  - Quote
  ed williams
  Participant
  Hi there Caman, here are a couple of links on Pd-L1 status and how it is measured and used in solid tumors not just melanoma. First video is melanoma specific and second one is good for first 30min and is solid tumor and lung cancer specific with a little melanoma sprinkled in. https://www.youtube.com/watch?v=5y1nnTsFBoE https://www.youtube.com/watch?v=c9tJtdxXVJY
  - April 29, 2020 at 7:37 pm
    
    Quote
    caman
    Participant
    
    Thanx Ed. Hope your well man… If I understood her correctly the best way to test for melanoma PDL1 is after the immunotherapy not before and not from a fine needle biopsy. I was tested before Keytruda and tested with fine needle biospy. I guess my PDL1 numbers are probably not too indicative. Am I correct with that assumption?
  - April 29, 2020 at 7:54 pm
    
    Quote
    ed williams
    Participant
    
    If you go to 14:00 min mark Dr. Jason Luke gets into your question and gives a good view of Pd-L1 and tumor staining and where Pd-L1 cells are found in tumor.http://www.researchtopractice.com/ImmunotherapyInterviews118/Video?playlistIndex=0#t=14m19s
  - April 29, 2020 at 9:24 pm
    
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    caman
    Participant
    
    Real good stuff. I’ve come to the conclusion after watching the videos you provided and reading Celeste info that pdL1 count can’t be done with a fine Needle biopsy. My doctor was real happy with the speed keytruda destroyed the melanoma and to him that’s more indicative than anything else. I should be content and stop googling…thanx man, appreciate all your help

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