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I do NOT presume to know all there is that is going on with your situation. However, in all my years dealing with melanoma and melanoma patients, PCP has never been a big issue. Unless your docs have some particular reason to think your risk for this is high, I would wish to come off Bactrim ASAP not because of a fear of developing resistance, but because (as was noted in one of the papers you sited) that we have learned that folks on antibiotics before or at the start of immunotherapy tend to have a poorer response.
As I note in all reports I post related to antibiotic use – when needed they are nothing short of life saving. So, if your docs think your risk is significant enough to require them – that is one thing. However, the data included in these many studies would certainly be something I would want to discuss.
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