› Forums › General Melanoma Community › ORGANIZING THE BRAF TRIALS: ATTENTION ALL BRAF TRIAL PATIENTS!
- This topic has 10 replies, 5 voices, and was last updated 14 years, 9 months ago by
sharmon.
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- May 18, 2011 at 11:58 pm
Having been out of the treatment loop, unfortunately, I have lost track of all of the different trials out there, so many letters, so many mutation types, so many histology tests so many drug companies and so on. I would like to start to organize the different medications (at least get started) so we can see what is working for who.
Having been out of the treatment loop, unfortunately, I have lost track of all of the different trials out there, so many letters, so many mutation types, so many histology tests so many drug companies and so on. I would like to start to organize the different medications (at least get started) so we can see what is working for who.
GSK 113929
is the number of a trial who "patient" I won't say it yet, is responding very well to. The drug is made by Glaxo Smith Kline, it is for people with BRAF mutations who also have brain mets.
This is the actual medication name: GSK2118436
The patient has responded amazingly well despite a severe recent relapse. For now consider this information to be similar to a statistic in a lab report.
The patient will give the patients own account with much more personality and entertaining details.
Just putting this one out there as it is helpful if you have brain mets, and are not responding.
Here is the link:
http://www.clinicaltrials.gov/ct2/show/study/NCT01266967?term=GSK+113929&rank=1&show_locs=Y#locn
Information that would be helpful:(just copy and paste this form and fill in your treatments)
Drug name/clinical trial letters/manufacturer
Trial Name
Drug Company
Response duration vs non Response
Previous Treatments
Mutation status.
Hopefully we can organize this information as to which companies are producing a better product. Back when Yervoy was being investigated, it was originally a biopharmaceutical startup made by a company named Medarex. Pfizer was making a similar product at the same time. For some reason, The Medarex one was better and zipped right through the clinical trials, it went from the names MDX 010 to Ipilimumab to finally Yervoy. Pfizers was simply discontinued.
Thank you and I hope this is a helpful start by patients for patients.
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- May 19, 2011 at 12:03 am
John,
If you get some good replies and decent info here, I could make a section for this info on my website. Just a thought.
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- May 19, 2011 at 12:11 am
Janner, you would be the perfect person to organize the information, I spoke to my derm about your website (first derm appt I actually went to since becoming stage IV, (I am happily able to nitpick about the bumps and scratches instead of bitching about going to the doctor) anyway, they kind of nodded their head like I was talking about some kooky alternative medicine, (I'm sure they hear all kinds of wacky crap from patients) but nonetheless, I think your website is better than most of the other crap that is on the web even the stuff by skin specialists that tend to have the same repetitive boring pictures, you even have patient testimonials and cool stuff like that. Would definitely appreciate your help.
John
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- May 19, 2011 at 12:11 am
Janner, you would be the perfect person to organize the information, I spoke to my derm about your website (first derm appt I actually went to since becoming stage IV, (I am happily able to nitpick about the bumps and scratches instead of bitching about going to the doctor) anyway, they kind of nodded their head like I was talking about some kooky alternative medicine, (I'm sure they hear all kinds of wacky crap from patients) but nonetheless, I think your website is better than most of the other crap that is on the web even the stuff by skin specialists that tend to have the same repetitive boring pictures, you even have patient testimonials and cool stuff like that. Would definitely appreciate your help.
John
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- May 19, 2011 at 5:22 am
Drug name/clinical trial letters/manufacturer GSK113929
Trial Name An Open-Label, Two-Cohort, Multicentre Study of GSK2118436 as a Single Agent in Treatment Naïve and Previously Treated Subjects With BRAF Mutation-Positive Metastatic Melanoma to the Brain
Drug Company GSK
Response duration vs non Response : "Dramatic Response" by week 3 (16/05/11- currently only had 3-4 weeks treatment)
Previous Treatments Surgeries, SRS, fotemustine, temozolomide
Mutation status BRAF V600E-
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- May 19, 2011 at 5:22 am
Drug name/clinical trial letters/manufacturer GSK113929
Trial Name An Open-Label, Two-Cohort, Multicentre Study of GSK2118436 as a Single Agent in Treatment Naïve and Previously Treated Subjects With BRAF Mutation-Positive Metastatic Melanoma to the Brain
Drug Company GSK
Response duration vs non Response : "Dramatic Response" by week 3 (16/05/11- currently only had 3-4 weeks treatment)
Previous Treatments Surgeries, SRS, fotemustine, temozolomide
Mutation status BRAF V600E-
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- May 19, 2011 at 6:00 am
Details of the BRAF/MEK trial I started last week:
Sponsor Company: GSK
Name of Trial: BRF113220: "An Open-Label, Dose Escalation,Phase I/II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activityof the BRAF Inhibitor GSK2118436 in Combination with the MEK Inhibitor GSK1120212 in Subjects with BRAF Mutant Metastatic Melanoma"
What a mouthful!
Person in Charge of the Research Study: Steven J. O'Day, MD
Address of Study Site: The Angeles Clinic and Research Institute
11818 Wilshire Blvd., Suite 200
Los Angeles, CA 90025
Phone: 310-582-7900
About 200 people, ages 18 years and older, in 2 countries, will take part. The study will last about 2 years.
My specs: Currently Stage IV with bone mets in clavicle (a big one!), hip, sacrum, and femur. Also at least one sub-q, and a suspect small nodule in lung.
My previous treatments: surgery (4 times), CancerVax (1997 -2000), and GM-CSF (2000 – 2002).
On 300 mg BRAF and 2 mg MEK per day (I got randomized to the arm with the max MEK).
I guess I was born to be a Guinea pig!
Best wishes,
Harry
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- May 19, 2011 at 6:00 am
Details of the BRAF/MEK trial I started last week:
Sponsor Company: GSK
Name of Trial: BRF113220: "An Open-Label, Dose Escalation,Phase I/II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activityof the BRAF Inhibitor GSK2118436 in Combination with the MEK Inhibitor GSK1120212 in Subjects with BRAF Mutant Metastatic Melanoma"
What a mouthful!
Person in Charge of the Research Study: Steven J. O'Day, MD
Address of Study Site: The Angeles Clinic and Research Institute
11818 Wilshire Blvd., Suite 200
Los Angeles, CA 90025
Phone: 310-582-7900
About 200 people, ages 18 years and older, in 2 countries, will take part. The study will last about 2 years.
My specs: Currently Stage IV with bone mets in clavicle (a big one!), hip, sacrum, and femur. Also at least one sub-q, and a suspect small nodule in lung.
My previous treatments: surgery (4 times), CancerVax (1997 -2000), and GM-CSF (2000 – 2002).
On 300 mg BRAF and 2 mg MEK per day (I got randomized to the arm with the max MEK).
I guess I was born to be a Guinea pig!
Best wishes,
Harry
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- May 19, 2011 at 5:47 pm
Hi, My husband is stage 4 and I think this is a great ideal . I hope this helps.
Drug name/clinical trial letters/manufacturer :
GSK 11202122 with Pemetrexed protocol 2010-0610
Trial Name:
GSK MEK Inhibitor with chemDrug Company:
Response duration vs non Response:
Was on MEK alone for 14 months then started to progress, Pemetrexed was add 3 weeks ago and all discomfort is gone.
Previous Treatments
Luekine 2008 , Ipi carbo/taxel 2009, Mek 2010 – March 2010, MEk with pemetrexed now
Mutation status.
Braf negative, pi3k negative, c-kit negative, nras negative, hla2 negative
Thanks
Brent and Sharon
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- May 19, 2011 at 5:47 pm
Hi, My husband is stage 4 and I think this is a great ideal . I hope this helps.
Drug name/clinical trial letters/manufacturer :
GSK 11202122 with Pemetrexed protocol 2010-0610
Trial Name:
GSK MEK Inhibitor with chemDrug Company:
Response duration vs non Response:
Was on MEK alone for 14 months then started to progress, Pemetrexed was add 3 weeks ago and all discomfort is gone.
Previous Treatments
Luekine 2008 , Ipi carbo/taxel 2009, Mek 2010 – March 2010, MEk with pemetrexed now
Mutation status.
Braf negative, pi3k negative, c-kit negative, nras negative, hla2 negative
Thanks
Brent and Sharon
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