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1Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Correspondence: Amy S. Paller, Department of Dermatology, Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 1600, Chicago, Illinois 60611, USA E-mail: [email protected]
Linking phenotypic patterns of melanocytic neoplasia to specific gene mutations allows more precise predicting of clinical behavior and response to targeted therapy. In this issue, Kinsler et al. provide evidence that multiple congenital nevi with central nervous system lesions are likely exclusively the result of mosaic mutations in NRAS. We discuss the link between mosaic NRAS mutations, cellular senescence, and clinical phenotype in these nevi.
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