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NRAS, Mosaicism, and Large Congenital Nevi
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NRAS, Mosaicism, and Large Congenital Nevi

› Forums › Pediatric & AYA Melanoma Community › NRAS, Mosaicism, and Large Congenital Nevi

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    • August 15, 2013 at 8:20 pm
    lou2
    Participant

      Commentary

      Journal of Investigative Dermatology (2013) 133, 2127–2130; doi:10.1038/jid.2013.146

      Commentary

      Journal of Investigative Dermatology (2013) 133, 2127–2130; doi:10.1038/jid.2013.146

      Making a Mountain Out of a Molehill: NRAS, Mosaicism, and Large Congenital Nevi

      Pedram Gerami1 and Amy S Paller1

      1Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

      Correspondence: Amy S. Paller, Department of Dermatology, Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 1600, Chicago, Illinois 60611, USA E-mail: [email protected]

      Abstract

      Linking phenotypic patterns of melanocytic neoplasia to specific gene mutations allows more precise predicting of clinical behavior and response to targeted therapy. In this issue, Kinsler et al. provide evidence that multiple congenital nevi with central nervous system lesions are likely exclusively the result of mosaic mutations in NRAS. We discuss the link between mosaic NRAS mutations, cellular senescence, and clinical phenotype in these nevi.

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