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Novartis–LEE011
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Novartis–LEE011

› Forums › General Melanoma Community › Novartis–LEE011

  • Post
    • December 6, 2013 at 8:44 pm
    Scuba Doc
    Participant

      Anyone have any experience with the Novartis drug –LEE011 for CDK4/6 and any severe side effects.I am possibly starting a clinical trial next week—-thanks in advance —-LindaG

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    • Replies
        • December 6, 2013 at 11:36 pm
        POW
        Participant

          The LEE011 Phase 1 clinical trials are brand new– just announced within the last month or so– so not very many of the folks here have experience with it yet.

          Apparently, LEE011 is a small molecule similar to MEK in some respects. Although researchers  hope that it will kill breast cancer, melanoma, and some other cancers, what they really expect is that it will perform especially well in combination  with other small molecule targeted treatments like the BRAF inhibitors by preventing the cancer cells from becoming resistant to the targeted therapies. 

          This is all pie-in-the-sky right now, but a series of Phase 1 trials of LEE011 alone and in combination have begun. Let's keep our fingers crossed! Please keep us posted about how things go for you.

          • December 6, 2013 at 11:36 pm
          POW
          Participant

            The LEE011 Phase 1 clinical trials are brand new– just announced within the last month or so– so not very many of the folks here have experience with it yet.

            Apparently, LEE011 is a small molecule similar to MEK in some respects. Although researchers  hope that it will kill breast cancer, melanoma, and some other cancers, what they really expect is that it will perform especially well in combination  with other small molecule targeted treatments like the BRAF inhibitors by preventing the cancer cells from becoming resistant to the targeted therapies. 

            This is all pie-in-the-sky right now, but a series of Phase 1 trials of LEE011 alone and in combination have begun. Let's keep our fingers crossed! Please keep us posted about how things go for you.

            • December 6, 2013 at 11:36 pm
            POW
            Participant

              The LEE011 Phase 1 clinical trials are brand new– just announced within the last month or so– so not very many of the folks here have experience with it yet.

              Apparently, LEE011 is a small molecule similar to MEK in some respects. Although researchers  hope that it will kill breast cancer, melanoma, and some other cancers, what they really expect is that it will perform especially well in combination  with other small molecule targeted treatments like the BRAF inhibitors by preventing the cancer cells from becoming resistant to the targeted therapies. 

              This is all pie-in-the-sky right now, but a series of Phase 1 trials of LEE011 alone and in combination have begun. Let's keep our fingers crossed! Please keep us posted about how things go for you.

                • December 7, 2013 at 1:21 pm
                Scuba Doc
                Participant

                  Thank You for the reply —looks like I will be starting the trial soon—-I will keep you posted–  LindaG

                  • December 8, 2013 at 1:34 am
                  BrianP
                  Participant

                    Best of luck to you Linda.  My hat goes off to you brave phase I'ners who are willing to take a chance so that others may benefit.  Look forward to your future post and pray for great results.  Where will you be enrolling in the trial?

                    Brian

                    • December 8, 2013 at 1:43 pm
                    Scuba Doc
                    Participant

                      Starting the trial at Dana-Farber Cancer Institute in Boston, MA.in the next couple of weeks —-thanks

                      • January 11, 2014 at 3:51 pm
                      Scuba Doc
                      Participant

                        We are also wondering if anyone knows if Merck has approved of a 'Compassionate Exemption' for the drug Lambrolizumab to any melanoma patient so far? 

                        • January 11, 2014 at 3:51 pm
                        Scuba Doc
                        Participant

                          We are also wondering if anyone knows if Merck has approved of a 'Compassionate Exemption' for the drug Lambrolizumab to any melanoma patient so far? 

                          • January 11, 2014 at 3:51 pm
                          Scuba Doc
                          Participant

                            We are also wondering if anyone knows if Merck has approved of a 'Compassionate Exemption' for the drug Lambrolizumab to any melanoma patient so far? 

                            • January 30, 2014 at 9:27 pm
                            Scuba Doc
                            Participant

                              We are now in the 2nd cycle —-3 weeks on 1 week off. Won't know of any changes after cts and mri for another 3 weeks. Very tired about 1 hour after taking the drug but no other side effects to speak of—-

                              • March 24, 2014 at 2:08 pm
                              Scuba Doc
                              Participant

                                CTs and MRIs show additional growth —- off of the trial and looking into another clinical trial in NYC —thanks to all of the contributors—– Linda G

                                • March 24, 2014 at 8:20 pm
                                POW
                                Participant

                                  Oh, shoot! I'm sorry for your disappointment. But thank you so much for volunteering to help test out this new drug. Without people like you, melanoma research would be dead in the water. 

                                  I assume that you know that Merck's anti-PD1 (MK-3475) is just becoming available for expanded access? Could that be an option for you? Or perhaps an antibody-drug conjugate (ADC) trial?

                                  • March 24, 2014 at 8:20 pm
                                  POW
                                  Participant

                                    Oh, shoot! I'm sorry for your disappointment. But thank you so much for volunteering to help test out this new drug. Without people like you, melanoma research would be dead in the water. 

                                    I assume that you know that Merck's anti-PD1 (MK-3475) is just becoming available for expanded access? Could that be an option for you? Or perhaps an antibody-drug conjugate (ADC) trial?

                                    • March 24, 2014 at 8:20 pm
                                    POW
                                    Participant

                                      Oh, shoot! I'm sorry for your disappointment. But thank you so much for volunteering to help test out this new drug. Without people like you, melanoma research would be dead in the water. 

                                      I assume that you know that Merck's anti-PD1 (MK-3475) is just becoming available for expanded access? Could that be an option for you? Or perhaps an antibody-drug conjugate (ADC) trial?

                                      • March 24, 2014 at 2:08 pm
                                      Scuba Doc
                                      Participant

                                        CTs and MRIs show additional growth —- off of the trial and looking into another clinical trial in NYC —thanks to all of the contributors—– Linda G

                                        • March 24, 2014 at 2:08 pm
                                        Scuba Doc
                                        Participant

                                          CTs and MRIs show additional growth —- off of the trial and looking into another clinical trial in NYC —thanks to all of the contributors—– Linda G

                                          • January 30, 2014 at 9:27 pm
                                          Scuba Doc
                                          Participant

                                            We are now in the 2nd cycle —-3 weeks on 1 week off. Won't know of any changes after cts and mri for another 3 weeks. Very tired about 1 hour after taking the drug but no other side effects to speak of—-

                                            • January 30, 2014 at 9:27 pm
                                            Scuba Doc
                                            Participant

                                              We are now in the 2nd cycle —-3 weeks on 1 week off. Won't know of any changes after cts and mri for another 3 weeks. Very tired about 1 hour after taking the drug but no other side effects to speak of—-

                                              • December 8, 2013 at 1:43 pm
                                              Scuba Doc
                                              Participant

                                                Starting the trial at Dana-Farber Cancer Institute in Boston, MA.in the next couple of weeks —-thanks

                                                • December 8, 2013 at 1:43 pm
                                                Scuba Doc
                                                Participant

                                                  Starting the trial at Dana-Farber Cancer Institute in Boston, MA.in the next couple of weeks —-thanks

                                                  • December 8, 2013 at 1:34 am
                                                  BrianP
                                                  Participant

                                                    Best of luck to you Linda.  My hat goes off to you brave phase I'ners who are willing to take a chance so that others may benefit.  Look forward to your future post and pray for great results.  Where will you be enrolling in the trial?

                                                    Brian

                                                    • December 8, 2013 at 1:34 am
                                                    BrianP
                                                    Participant

                                                      Best of luck to you Linda.  My hat goes off to you brave phase I'ners who are willing to take a chance so that others may benefit.  Look forward to your future post and pray for great results.  Where will you be enrolling in the trial?

                                                      Brian

                                                      • December 7, 2013 at 1:21 pm
                                                      Scuba Doc
                                                      Participant

                                                        Thank You for the reply —looks like I will be starting the trial soon—-I will keep you posted–  LindaG

                                                        • December 7, 2013 at 1:21 pm
                                                        Scuba Doc
                                                        Participant

                                                          Thank You for the reply —looks like I will be starting the trial soon—-I will keep you posted–  LindaG

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