› Forums › General Melanoma Community › No vitiligo?
- This topic has 4 replies, 4 voices, and was last updated 2 years, 1 month ago by
YoJa.
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- January 18, 2023 at 1:25 pm
Immunotherapy vitiligo is much different than the definition given above. Most individuals who respond to immunotherapy whether partially or completely will not have vitiligo. I did however develop vitiligo late into treatment. I failed Pembrolizumab and after receiving the ipi/nivo combo the condition developed. My vitligo showed up all over my groin where I had tumors. Large random patches of my hair fell out and came back white. My Scars turned white and anywhere else I had tumors (Legs, Feet) also turned white. This condition is not something to count on, but something random that could happen, likely when you’re least expecting it. I had Stage 4 acral melanoma and did have a complete response after many failed drugs (Pembro, Single Nivo, T-VEC.) -
- January 19, 2023 at 8:19 pm
I did not have any vitiligo during my 12-month adjuvant nivo treatment for stage 3a/b. After progressing a year after that initial 12 months in lung and groin, I started ipi/nivo every three weeks for 3 months. I did not respond initially (and was asymptomatic). However, two months after my last dose of the combo I developed vitiligo and some rheumatoid arthritis. My facial hair became patchy white, and I noticed some “halos” of unpigmented skin around moles on my arm. My lung tumor and groin lymph node disappeared.Unfortunately after about 4 months of this initial response, I progressed in the brain, as well as a few subcutaneous lesions and a lymph node. Currently I am on a TIL trial, but my beard is still white 🙂
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