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NIH Scientists Discover Secrets Of Helper T Cells Involved In Autoimmunity

Forums General Melanoma Community NIH Scientists Discover Secrets Of Helper T Cells Involved In Autoimmunity

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    jim Breitfeller
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      NIH Scientists Discover Secrets Of Helper T Cells Involved In Autoimmunity

       

      NIH Scientists Discover Secrets Of Helper T Cells Involved In Autoimmunity

       

      WHAT
      Scientists at the National Institutes of Health have redefined the roles of several cytokines involved in the generation of immune cells implicated in severe autoimmune diseases. The study in mice showed that development of Th17 immune cells can occur without the presence of transforming growth factor (TGF)-beta, a mediator thought to be required for Th17 cell development. The study demonstrates that the interaction of three inflammatory cytokines (proteins that influence the behavior of cells) – interleukin-6 (IL-6), IL-1-beta and IL-23 – is responsible for the creation of Th17 cells that are more active in promoting autoimmunity than Th17 cells generated with IL-6, IL-1-beta and TGF-beta. These findings reemphasize the separate roles of IL-23 and TGF-beta in immunity and autoimmunity, and open up possibilities for the development of new therapies. The study appears in the current issue of the journal Nature.

      You may want to go to Melanoma Missionary website and read the last couple of posts.

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