› Forums › General Melanoma Community › more people die from thin melanomas than thick melanomas
- This topic has 30 replies, 7 voices, and was last updated 10 years, 1 month ago by JerryfromFauq.
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- November 17, 2014 at 1:06 pm
I'm not sure I understand this study, maybe janner can explain in layman's terms
http://www.reuters.com/article/2014/11/13/us-public-health-melanoma-idUSKCN0IX25S20141113
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- November 17, 2014 at 2:45 pm
I'm not sure I think the researchers have a valid premise for the argument. Based on the article alone, though, it does seem to validate my concern that thin lesions should be treated more aggressively. What if we are seeing more deaths from people who were originally diagnosed with a Stage 1 lesion, but were never offered an SNB? Maybe those patients were really Stage 3 at the time of diagnosis, and had they started treatment immediately they would not have progressed to Stage 4? I'm sure it is a risk/reward analysis. SNB has inherent risks, it is costly, etc. — but has there ever been a study done on the outcomes of SNB for Stage 1 patients?
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- November 17, 2014 at 2:45 pm
I'm not sure I think the researchers have a valid premise for the argument. Based on the article alone, though, it does seem to validate my concern that thin lesions should be treated more aggressively. What if we are seeing more deaths from people who were originally diagnosed with a Stage 1 lesion, but were never offered an SNB? Maybe those patients were really Stage 3 at the time of diagnosis, and had they started treatment immediately they would not have progressed to Stage 4? I'm sure it is a risk/reward analysis. SNB has inherent risks, it is costly, etc. — but has there ever been a study done on the outcomes of SNB for Stage 1 patients?
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- November 17, 2014 at 4:14 pm
More people die fron thin melanomas because a lot more people get thin ones than thick ones that doesnt mean that thin ones are more deadly just there are a heck of a lot more of them.
And SNB doesnt offer any OS benefit in any case.
There is a test which i mentioned in another thread here that has more predictive value than current staging protocols and that is a Circulating Tumour Cell test. There is plenty of research around it and it can predict distant spread better than current staging protocols. In fact I think it is the way of the future in cancer treatment as it can be used to monitor effectiveness of current treatment and whether you need to be more aggressive or not based on high much cancer is running around the bloodstream.
There are a couple fo different CTC tests. Cell Search i think is used in US and Maintrac in Germany and i think there may be another one as well.
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- November 17, 2014 at 4:14 pm
More people die fron thin melanomas because a lot more people get thin ones than thick ones that doesnt mean that thin ones are more deadly just there are a heck of a lot more of them.
And SNB doesnt offer any OS benefit in any case.
There is a test which i mentioned in another thread here that has more predictive value than current staging protocols and that is a Circulating Tumour Cell test. There is plenty of research around it and it can predict distant spread better than current staging protocols. In fact I think it is the way of the future in cancer treatment as it can be used to monitor effectiveness of current treatment and whether you need to be more aggressive or not based on high much cancer is running around the bloodstream.
There are a couple fo different CTC tests. Cell Search i think is used in US and Maintrac in Germany and i think there may be another one as well.
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- November 18, 2014 at 12:26 am
Futher development and approval of the tests you mentioned will be a big break thru. I als notice that there was no mention of the mitsosis srate which is another importandt factor in prognosis.
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- November 18, 2014 at 12:26 am
Futher development and approval of the tests you mentioned will be a big break thru. I als notice that there was no mention of the mitsosis srate which is another importandt factor in prognosis.
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- November 18, 2014 at 12:26 am
Futher development and approval of the tests you mentioned will be a big break thru. I als notice that there was no mention of the mitsosis srate which is another importandt factor in prognosis.
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- November 17, 2014 at 4:14 pm
More people die fron thin melanomas because a lot more people get thin ones than thick ones that doesnt mean that thin ones are more deadly just there are a heck of a lot more of them.
And SNB doesnt offer any OS benefit in any case.
There is a test which i mentioned in another thread here that has more predictive value than current staging protocols and that is a Circulating Tumour Cell test. There is plenty of research around it and it can predict distant spread better than current staging protocols. In fact I think it is the way of the future in cancer treatment as it can be used to monitor effectiveness of current treatment and whether you need to be more aggressive or not based on high much cancer is running around the bloodstream.
There are a couple fo different CTC tests. Cell Search i think is used in US and Maintrac in Germany and i think there may be another one as well.
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- November 17, 2014 at 2:45 pm
I'm not sure I think the researchers have a valid premise for the argument. Based on the article alone, though, it does seem to validate my concern that thin lesions should be treated more aggressively. What if we are seeing more deaths from people who were originally diagnosed with a Stage 1 lesion, but were never offered an SNB? Maybe those patients were really Stage 3 at the time of diagnosis, and had they started treatment immediately they would not have progressed to Stage 4? I'm sure it is a risk/reward analysis. SNB has inherent risks, it is costly, etc. — but has there ever been a study done on the outcomes of SNB for Stage 1 patients?
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- November 17, 2014 at 4:35 pm
To me, this study reflects what many of us who have spent time on melanoma forums have seen in real life – there are always people who turn up with advanced melanoma after having been diagnosed with a thin, stage I melanoma a few years prior.
They are not saying thin melanoma does not still have an excellent prognosis, or that thin melanoma is more deadly than thicker, just that SOME thin melanoma does turn deadly, apparently the average time frame in the study being 6 years, and my impression is that the researchers are saying we need better methods of followup in place for these patients to increase early detection. It's true that people with thin melanoma tend to be offered minimal followup. It sounds like in general because of the excellent prognosis, this is fine, but for a small percentage this lack of closer followup can be deadly.
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- November 17, 2014 at 4:35 pm
To me, this study reflects what many of us who have spent time on melanoma forums have seen in real life – there are always people who turn up with advanced melanoma after having been diagnosed with a thin, stage I melanoma a few years prior.
They are not saying thin melanoma does not still have an excellent prognosis, or that thin melanoma is more deadly than thicker, just that SOME thin melanoma does turn deadly, apparently the average time frame in the study being 6 years, and my impression is that the researchers are saying we need better methods of followup in place for these patients to increase early detection. It's true that people with thin melanoma tend to be offered minimal followup. It sounds like in general because of the excellent prognosis, this is fine, but for a small percentage this lack of closer followup can be deadly.
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- November 17, 2014 at 4:35 pm
To me, this study reflects what many of us who have spent time on melanoma forums have seen in real life – there are always people who turn up with advanced melanoma after having been diagnosed with a thin, stage I melanoma a few years prior.
They are not saying thin melanoma does not still have an excellent prognosis, or that thin melanoma is more deadly than thicker, just that SOME thin melanoma does turn deadly, apparently the average time frame in the study being 6 years, and my impression is that the researchers are saying we need better methods of followup in place for these patients to increase early detection. It's true that people with thin melanoma tend to be offered minimal followup. It sounds like in general because of the excellent prognosis, this is fine, but for a small percentage this lack of closer followup can be deadly.
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- November 17, 2014 at 6:23 pm
Articles like this is what confuses me… First this group was trying to reassure everyone thin melanomas have an excellent prognosis.. Matter of fact, they said they were seeing people live 20 years or longer from intial diagnosis. Now they are saying there are more deaths from thin melanomas than thick ones. I think they truly don't even know. And until they do know for a fact they need to quit putting anything out there for the people to read. "Thin melanomas have an excellent survival rate, but more people die from them." Isn't that like an oxymoron???? We don't need any more anxiety than we already have from our diagnosis. So, they need to quit guesstimating and start finding actual cures for this horrible disease.
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- November 17, 2014 at 6:23 pm
Articles like this is what confuses me… First this group was trying to reassure everyone thin melanomas have an excellent prognosis.. Matter of fact, they said they were seeing people live 20 years or longer from intial diagnosis. Now they are saying there are more deaths from thin melanomas than thick ones. I think they truly don't even know. And until they do know for a fact they need to quit putting anything out there for the people to read. "Thin melanomas have an excellent survival rate, but more people die from them." Isn't that like an oxymoron???? We don't need any more anxiety than we already have from our diagnosis. So, they need to quit guesstimating and start finding actual cures for this horrible disease.
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- November 17, 2014 at 6:23 pm
Articles like this is what confuses me… First this group was trying to reassure everyone thin melanomas have an excellent prognosis.. Matter of fact, they said they were seeing people live 20 years or longer from intial diagnosis. Now they are saying there are more deaths from thin melanomas than thick ones. I think they truly don't even know. And until they do know for a fact they need to quit putting anything out there for the people to read. "Thin melanomas have an excellent survival rate, but more people die from them." Isn't that like an oxymoron???? We don't need any more anxiety than we already have from our diagnosis. So, they need to quit guesstimating and start finding actual cures for this horrible disease.
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- November 18, 2014 at 12:22 am
I sure cannot explain their numbers. Maybe I'm too tired to be able to read tonight. They appear to be a mismatch of number and definitions between countries, usage of old date even thou published Thu Nov 13, 2014 12:34pm EST and they state "An estimated 76,100 new cases will be diagnosed this year and 9,710 people will die from the disease. " The numbers of new cases I have seen estimated for 2014 are around 100,000.
They reference other news articles, not peer reviewed journals.
"Past research has found that patients with thin lesions (less than or equal to 1 millimeter) survived, on average, for 20 years after diagnosis, while those with thicker melanomas were more likely to die years sooner." WHAT DID THEY DIE FROM?? Melanoma, car wrecks, war, old age? ??
Then they say:
"People with thin lesions died about six years after they were diagnosed, while those with thick lesions died two years after the melanoma was detected, according to the data."
i have sppent more time on this article than it seseerves. It should never have been publihed.
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- November 18, 2014 at 12:22 am
I sure cannot explain their numbers. Maybe I'm too tired to be able to read tonight. They appear to be a mismatch of number and definitions between countries, usage of old date even thou published Thu Nov 13, 2014 12:34pm EST and they state "An estimated 76,100 new cases will be diagnosed this year and 9,710 people will die from the disease. " The numbers of new cases I have seen estimated for 2014 are around 100,000.
They reference other news articles, not peer reviewed journals.
"Past research has found that patients with thin lesions (less than or equal to 1 millimeter) survived, on average, for 20 years after diagnosis, while those with thicker melanomas were more likely to die years sooner." WHAT DID THEY DIE FROM?? Melanoma, car wrecks, war, old age? ??
Then they say:
"People with thin lesions died about six years after they were diagnosed, while those with thick lesions died two years after the melanoma was detected, according to the data."
i have sppent more time on this article than it seseerves. It should never have been publihed.
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- November 18, 2014 at 12:22 am
I sure cannot explain their numbers. Maybe I'm too tired to be able to read tonight. They appear to be a mismatch of number and definitions between countries, usage of old date even thou published Thu Nov 13, 2014 12:34pm EST and they state "An estimated 76,100 new cases will be diagnosed this year and 9,710 people will die from the disease. " The numbers of new cases I have seen estimated for 2014 are around 100,000.
They reference other news articles, not peer reviewed journals.
"Past research has found that patients with thin lesions (less than or equal to 1 millimeter) survived, on average, for 20 years after diagnosis, while those with thicker melanomas were more likely to die years sooner." WHAT DID THEY DIE FROM?? Melanoma, car wrecks, war, old age? ??
Then they say:
"People with thin lesions died about six years after they were diagnosed, while those with thick lesions died two years after the melanoma was detected, according to the data."
i have sppent more time on this article than it seseerves. It should never have been publihed.
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