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Mixed results for TIL – Back to the drawing board
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Mixed results for TIL – Back to the drawing board

› Forums › Mixed results for TIL – Back to the drawing board

  • Post
    • November 25, 2020 at 12:27 am
    chipgoodhue
    Participant
      Rose got through her TIL trial at SCCA bravely, and saw complete and rapid reduction in her head, neck and lung tumors. Unfortunately, the 42 day scans showed major progression in the liver. Very puzzling for the trial team. We have been referred back to our on oncologist for next steps.

      Anyone have similar mixed response with TIL? Thoughts on what next?. Pretty sure she will go back on braf/mek in short term.

      We are scared and concerned about running out of options.

      Chip

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        • November 25, 2020 at 2:32 am
        Bubbles
        Participant
          Glad to hear of rapid tumor reduction in some areas and that Rose is, unsurprisingly, one tough cookie! Unfortunately, melanoma liver lesions are known to be persistent and difficult. I’ve posted various reports to that effect. However, there are reports in the literature and anecdotally shared by melanoma patients that radiation can be very helpful.

          The second article in this report addresses stereotactic ablative radiation therapy of the liver: https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/11/radiation-and-ipi-better-responses-than.html

          There is this from Sloan Kettering: https://www.mskcc.org/cancer-care/types/liver-metastases/treatment/radiation-therapy

          And there was a patient on this forum (sorry – can’t remember who) who had some success with radiation to a liver met in the form of brachytherapy – the placement of radioactive seeds in persistent lesions. Here is a little report: https://www.cancer.gov/about-cancer/treatment/types/radiation-therapy/brachytherapy

          I don’t know if radiation to the liver would be something that would work for her or that you are interested in. But, I figure it is worth a discussion with her docs. Wishing you both my best. Celeste

            • November 25, 2020 at 5:52 pm
            chipgoodhue
            Participant
              Thank you Celeste. She has extensive lesions in the liver so don’t know if radiation is in order but will address in our consults with both SCCA and cc next week. She was responsive to a short dose of braf mek, hopeful that if she goes back on it the liver will respond…need to do more research on that. Needless to say we are disappointed and scared…the TIL trial was brutal and we were not prepared for bad news.

              Best.

              Chip

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