› Forums › General Melanoma Community › mitotic rate
- This topic has 8 replies, 2 voices, and was last updated 5 years ago by Cooper.
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- April 22, 2019 at 5:35 pm
Hi KB, if you go to page 8 and 9 of new staging document "8th edition" you will see that mitotic rate has been droppen when considering staging of patients. They don't give a very detailed reason why but I would assume that the stats or precision of test didn't pass the grade, so going forward when considering staging mitotic rate is out. https://cancerstaging.org/CSE/Physician/Documents/Melanoma%202.2.18.pdf
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- April 22, 2019 at 9:02 pm
Not true Ed. Mitotic rate is still a widely used item on the pathology report to decide whether the patient needs more careful attention. It is the rate at which the cells are dividing. But always the Breslow depth is first in the pathology to consider for further scrutiny.
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- April 22, 2019 at 9:08 pm
https://journals.lww.com/dermatologicsurgery/Citation/2018/04000/Commentary_on_Impact_of_National_Comprehensive.4.aspx Mitotic rate is important to decide whether a SLNB is done or not.
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- April 22, 2019 at 9:42 pm
Dear Anon, if you read the last paragraph of the incomplete article that you posted it brings up the issue of how NCCN will look at staging after AJCC article (the one I posted above) has removed mitosis rate as a factor in the new staging document. It does say that they will still collect the information and will be imployed for clinical tool development. Here is a link with more detail. https://www.skincancer.org/publications/the-melanoma-letter/2018-vol-36-no-1/ajcc-staging-system
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- April 22, 2019 at 9:45 pm
In the following link, if you go to the section on "major changes" then read first paragraph after "Table one" you will find more information why mititoc rate was dropped from 8th edition. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978683/
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