mitotic rate
REGISTER
The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Content within the patient forum is user-generated and has not been reviewed by medical professionals. Other sections of the Melanoma Research Foundation website include information that has been reviewed by medical professionals as appropriate. All medical decisions should be made in consultation with your doctor or other qualified medical professional.

mitotic rate

› Forums › General Melanoma Community › mitotic rate

  • Post
    • April 22, 2019 at 4:52 pm
    kb9718
    Participant

    I was just wondering what the mitotic rate meant? Mine is 8 which seems really high and Im not to sure what to think of it. If it is something to worry about alot in the future. Hope everyone is doing well and wishing everyone all the best 

    kb

Viewing 0 reply threads
  • Replies
      • April 22, 2019 at 5:35 pm
      ed williams
      Participant

      Hi KB, if you go to page 8 and 9 of new staging document "8th edition" you will see that mitotic rate has been droppen when considering staging of patients. They don't give a very detailed reason why but I would assume that the stats or precision of test didn't pass the grade, so going forward when considering staging mitotic rate is out. https://cancerstaging.org/CSE/Physician/Documents/Melanoma%202.2.18.pdf

        • April 22, 2019 at 9:02 pm
        Cooper
        Participant

        Not true Ed.  Mitotic rate is still a widely used item on the pathology report to decide whether the patient needs more careful attention. It is the rate at which the cells are dividing.  But always the Breslow depth is first in the pathology to consider for further scrutiny.

        • April 22, 2019 at 9:08 pm
        Cooper
        Participant
        • April 22, 2019 at 9:42 pm
        ed williams
        Participant

        Dear Anon, if you read the last paragraph of the incomplete article that you posted it brings up the issue of how NCCN will look at staging after AJCC article (the one I posted above) has removed mitosis rate as a factor in the new staging document. It does say that they will still collect the information and will be imployed for clinical tool development. Here is a link with more detail. https://www.skincancer.org/publications/the-melanoma-letter/2018-vol-36-no-1/ajcc-staging-system

        • April 22, 2019 at 9:45 pm
        ed williams
        Participant

        In the following link, if you go to the section on "major changes" then read first paragraph after "Table one" you will find more information why mititoc rate was dropped from 8th edition. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978683/

        • April 25, 2019 at 6:54 pm
        Cooper
        Participant

        Yes despite being dropped it is still something dermatopathologists use as a tool.  It determines the rate of cell division.  So a low depth but high mitotic would mean a higher risk for recur.

        • April 25, 2019 at 6:58 pm
        Cooper
        Participant

        Ed in the article you quote it finalizes the mitotic opinion with: Mitotic rate remains a major determinant of prognosis across tumor thickness categories and should be documented in all primary invasive melanomas.

        • April 25, 2019 at 7:02 pm
        Cooper
        Participant

        So yes KB  the mitotic rate of 8 does mean to pay close attention to whether a SLNB should be done.  How deep was your melanoma?  Put these two factors together to figure out your risk and what to do.

         

Viewing 0 reply threads
  • You must be logged in to reply to this topic.
About the MRF Patient Forum

The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.