› Forums › General Melanoma Community › Mebendazole?
- This topic has 40 replies, 5 voices, and was last updated 10 months, 1 week ago by
Pajarito.
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- January 28, 2017 at 11:25 pm
Just very curious to be honest.,, I've read some reliable material about the use of mebendazole and the potential for it to aid cell death in melanoma.
Had anyone tried this? Or heard of its use?
would really appreciate anyone's input… is it all nonsense or could it have some value?
Many thanks x
- Replies
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- January 29, 2017 at 10:24 am
Hi,
Have read about it incombo with statins, metformin and doxycilne.The theory is that these drugs in combination disrupt the cancer cells metabolic pathway. They are old drugs and clinical trials are expensivre, so little money to be made by proving they work.
There is some triaKling being done in the UK, and it seems to include St Georges hospital. Usual buzz words repurposing of old drugs.Still have my sceptical hat on…but could see how in theory the drugs may do something.. But the UK clinic supplies the same drugs for all cancers and the registered trial on clinical trials.gov was suspended when I looked at it,and was only available for palliative patients.
Would be skeptical about using alongside say immunotherapy as doxyciline an antibiotic would mess with gut bacteria. Mebendazole is used to treat thread worm and usually only short courses so not sure how this might impact on say liver toxicity over longer courses. Statins must be used by lots of cancer patients- lowering bp and cholestral , same goes for metformin which is used in type 2 diabetes and keeps blood sugar levels down.
There may be something in this..but the evidence for the drugs is stronger on cancer risk reduction rather than treatment. Still trying to work out what I think , but am wary of unknown drug interactions. Maybe that tney disrupt the tumours micro environment.
Problem remains getting quality research done. There might be evidence in mouse models but it is a big step to say this works for us folk.
I' m firmly on the fence on this one.
Deb
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- January 29, 2017 at 10:24 am
Hi,
Have read about it incombo with statins, metformin and doxycilne.The theory is that these drugs in combination disrupt the cancer cells metabolic pathway. They are old drugs and clinical trials are expensivre, so little money to be made by proving they work.
There is some triaKling being done in the UK, and it seems to include St Georges hospital. Usual buzz words repurposing of old drugs.Still have my sceptical hat on…but could see how in theory the drugs may do something.. But the UK clinic supplies the same drugs for all cancers and the registered trial on clinical trials.gov was suspended when I looked at it,and was only available for palliative patients.
Would be skeptical about using alongside say immunotherapy as doxyciline an antibiotic would mess with gut bacteria. Mebendazole is used to treat thread worm and usually only short courses so not sure how this might impact on say liver toxicity over longer courses. Statins must be used by lots of cancer patients- lowering bp and cholestral , same goes for metformin which is used in type 2 diabetes and keeps blood sugar levels down.
There may be something in this..but the evidence for the drugs is stronger on cancer risk reduction rather than treatment. Still trying to work out what I think , but am wary of unknown drug interactions. Maybe that tney disrupt the tumours micro environment.
Problem remains getting quality research done. There might be evidence in mouse models but it is a big step to say this works for us folk.
I' m firmly on the fence on this one.
Deb
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- January 29, 2017 at 11:16 am
Thanks Deb. That's all really informative and very helpful.
My hubby is stage 3a and on no treatment. It's that frustrating point at which he feels he wants to be 'doing something' about reducing the risk. Seems crazy that he's had the surgery and unfortunately nothing else to offer to kill those remaining cancer cells. He's on no other drugs and for and healthy. So our thinking was maybe it could be useful to try a short course of this. We fully expect it to have no impact, but hey it could do. The research seems to suggest it could have some effect on cells. Side effects seem minimal and no specific danger. It doesn't seem quackery. Was thinking of discussing with the GP, but when u talk about things outside of the box, it is usually met with disapproval. Even when these things have some scientific backing.
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- January 29, 2017 at 11:16 am
Thanks Deb. That's all really informative and very helpful.
My hubby is stage 3a and on no treatment. It's that frustrating point at which he feels he wants to be 'doing something' about reducing the risk. Seems crazy that he's had the surgery and unfortunately nothing else to offer to kill those remaining cancer cells. He's on no other drugs and for and healthy. So our thinking was maybe it could be useful to try a short course of this. We fully expect it to have no impact, but hey it could do. The research seems to suggest it could have some effect on cells. Side effects seem minimal and no specific danger. It doesn't seem quackery. Was thinking of discussing with the GP, but when u talk about things outside of the box, it is usually met with disapproval. Even when these things have some scientific backing.
-
- January 29, 2017 at 11:16 am
Thanks Deb. That's all really informative and very helpful.
My hubby is stage 3a and on no treatment. It's that frustrating point at which he feels he wants to be 'doing something' about reducing the risk. Seems crazy that he's had the surgery and unfortunately nothing else to offer to kill those remaining cancer cells. He's on no other drugs and for and healthy. So our thinking was maybe it could be useful to try a short course of this. We fully expect it to have no impact, but hey it could do. The research seems to suggest it could have some effect on cells. Side effects seem minimal and no specific danger. It doesn't seem quackery. Was thinking of discussing with the GP, but when u talk about things outside of the box, it is usually met with disapproval. Even when these things have some scientific backing.
-
- January 29, 2017 at 10:24 am
Hi,
Have read about it incombo with statins, metformin and doxycilne.The theory is that these drugs in combination disrupt the cancer cells metabolic pathway. They are old drugs and clinical trials are expensivre, so little money to be made by proving they work.
There is some triaKling being done in the UK, and it seems to include St Georges hospital. Usual buzz words repurposing of old drugs.Still have my sceptical hat on…but could see how in theory the drugs may do something.. But the UK clinic supplies the same drugs for all cancers and the registered trial on clinical trials.gov was suspended when I looked at it,and was only available for palliative patients.
Would be skeptical about using alongside say immunotherapy as doxyciline an antibiotic would mess with gut bacteria. Mebendazole is used to treat thread worm and usually only short courses so not sure how this might impact on say liver toxicity over longer courses. Statins must be used by lots of cancer patients- lowering bp and cholestral , same goes for metformin which is used in type 2 diabetes and keeps blood sugar levels down.
There may be something in this..but the evidence for the drugs is stronger on cancer risk reduction rather than treatment. Still trying to work out what I think , but am wary of unknown drug interactions. Maybe that tney disrupt the tumours micro environment.
Problem remains getting quality research done. There might be evidence in mouse models but it is a big step to say this works for us folk.
I' m firmly on the fence on this one.
Deb
-
- January 29, 2017 at 4:10 pm
Hi AvaL,
Sorry for what you and your husband are dealing with. I have seen some data in the past re mebendazole that sounded positive. However, long term use could certainly have possible side effects. Your husband clearly has the right to decide what he feels is best for him. However, of all the things that have been looked at (from drugs most commonly used for other purposes – NSAID's, doxycycline, metformin, etc – to foods and plants) taking advil, eating more curry or mustard (or a curcumin tab), drinking coffee, taking vitamin D, and getting exercise may prove more helpful than anything else. I've followed the data on all sorts of melanoma "cures" over many years. Here is my latest installment with many, many links within: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/08/everything-cures-melanomaredux5.html
There is also this latest re metformin: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2017/01/phenformin-not-metformin-can-reduce.html
More on NSAID's below….
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- January 29, 2017 at 4:10 pm
Hi AvaL,
Sorry for what you and your husband are dealing with. I have seen some data in the past re mebendazole that sounded positive. However, long term use could certainly have possible side effects. Your husband clearly has the right to decide what he feels is best for him. However, of all the things that have been looked at (from drugs most commonly used for other purposes – NSAID's, doxycycline, metformin, etc – to foods and plants) taking advil, eating more curry or mustard (or a curcumin tab), drinking coffee, taking vitamin D, and getting exercise may prove more helpful than anything else. I've followed the data on all sorts of melanoma "cures" over many years. Here is my latest installment with many, many links within: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/08/everything-cures-melanomaredux5.html
There is also this latest re metformin: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2017/01/phenformin-not-metformin-can-reduce.html
More on NSAID's below….
-
- January 29, 2017 at 4:10 pm
Hi AvaL,
Sorry for what you and your husband are dealing with. I have seen some data in the past re mebendazole that sounded positive. However, long term use could certainly have possible side effects. Your husband clearly has the right to decide what he feels is best for him. However, of all the things that have been looked at (from drugs most commonly used for other purposes – NSAID's, doxycycline, metformin, etc – to foods and plants) taking advil, eating more curry or mustard (or a curcumin tab), drinking coffee, taking vitamin D, and getting exercise may prove more helpful than anything else. I've followed the data on all sorts of melanoma "cures" over many years. Here is my latest installment with many, many links within: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/08/everything-cures-melanomaredux5.html
There is also this latest re metformin: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2017/01/phenformin-not-metformin-can-reduce.html
More on NSAID's below….
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- January 29, 2017 at 4:19 pm
…NSAIDs were discussed at ASCO this past year. Check out the last article in this post (as well as the links to more links within): http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-final-odds-and-endsa-study.html
And there was this study that looked at routine drugs being taken by patients while on ipi: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/09/a-look-at-effect-of-routine-meds-used.html
Soooo….there is actually real live data on some of this stuff though urban legend has it that because it is already on the market and cheap…studies have never been done. You can find data on Vit D by using the search bubble on my blog if you are interested. I will be posting an additional abstract re Vit D tomorrow.
I wish you and your husband well….whatever you decide. celeste
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- January 29, 2017 at 4:19 pm
…NSAIDs were discussed at ASCO this past year. Check out the last article in this post (as well as the links to more links within): http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-final-odds-and-endsa-study.html
And there was this study that looked at routine drugs being taken by patients while on ipi: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/09/a-look-at-effect-of-routine-meds-used.html
Soooo….there is actually real live data on some of this stuff though urban legend has it that because it is already on the market and cheap…studies have never been done. You can find data on Vit D by using the search bubble on my blog if you are interested. I will be posting an additional abstract re Vit D tomorrow.
I wish you and your husband well….whatever you decide. celeste
-
- January 29, 2017 at 4:19 pm
…NSAIDs were discussed at ASCO this past year. Check out the last article in this post (as well as the links to more links within): http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/06/asco-2016-final-odds-and-endsa-study.html
And there was this study that looked at routine drugs being taken by patients while on ipi: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2016/09/a-look-at-effect-of-routine-meds-used.html
Soooo….there is actually real live data on some of this stuff though urban legend has it that because it is already on the market and cheap…studies have never been done. You can find data on Vit D by using the search bubble on my blog if you are interested. I will be posting an additional abstract re Vit D tomorrow.
I wish you and your husband well….whatever you decide. celeste
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- January 29, 2017 at 4:59 pm
Thank you for your research. I am still kind of a newbie here, had SLNB 2 weeks ago, now learning about living with MM. I know vitamin D is important, especially since I am going to avoid sun as much as I can, no more beaches or mountain hiking…
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- January 29, 2017 at 4:59 pm
Thank you for your research. I am still kind of a newbie here, had SLNB 2 weeks ago, now learning about living with MM. I know vitamin D is important, especially since I am going to avoid sun as much as I can, no more beaches or mountain hiking…
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- January 29, 2017 at 4:59 pm
Thank you for your research. I am still kind of a newbie here, had SLNB 2 weeks ago, now learning about living with MM. I know vitamin D is important, especially since I am going to avoid sun as much as I can, no more beaches or mountain hiking…
-
- January 29, 2017 at 10:16 pm
Hi Celeste thanks so much for replying. I found your blog a couple of months ago whilst I was furiously and probably obsessively (!) reading all I could about melanoma. So much info on there which you have spent time interpreting to make it more accessible. I check in often on there. It seems this melanoma makes me crave all the info I can get and once I feel satisfi d I have that… then I can get on with enjoying life…. until the next wobble and I then start looking again. Deary me, atleast it's interesting noting our own processes and patterns! But seriously, thank you – your work on that blog helps many I'm sure x
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- January 29, 2017 at 10:16 pm
Hi Celeste thanks so much for replying. I found your blog a couple of months ago whilst I was furiously and probably obsessively (!) reading all I could about melanoma. So much info on there which you have spent time interpreting to make it more accessible. I check in often on there. It seems this melanoma makes me crave all the info I can get and once I feel satisfi d I have that… then I can get on with enjoying life…. until the next wobble and I then start looking again. Deary me, atleast it's interesting noting our own processes and patterns! But seriously, thank you – your work on that blog helps many I'm sure x
-
- January 29, 2017 at 10:16 pm
Hi Celeste thanks so much for replying. I found your blog a couple of months ago whilst I was furiously and probably obsessively (!) reading all I could about melanoma. So much info on there which you have spent time interpreting to make it more accessible. I check in often on there. It seems this melanoma makes me crave all the info I can get and once I feel satisfi d I have that… then I can get on with enjoying life…. until the next wobble and I then start looking again. Deary me, atleast it's interesting noting our own processes and patterns! But seriously, thank you – your work on that blog helps many I'm sure x
-
- January 29, 2017 at 5:19 pm
Hi Aval,
Was on the tablet earlier – so apologies for the multiple typos- fat fingers and all that.
Some links for you to have a look at…If there is no risk of disrupting the mechanism of other treatments it might shift the balance in weighing pros and cons….Not easy to make a call.I do take tumeric, probiotics and Vit D.
The trial design had patients on mebendazole for a month alternating with the antibiotic…
http://www.telegraph.co.uk/wellbeing/health-advice/crowdfunding-cure-cancer/
https://clinicaltrials.gov/ct2/show/NCT02201381?term=metformin+mebendazole&rank=1
-
- January 29, 2017 at 5:19 pm
Hi Aval,
Was on the tablet earlier – so apologies for the multiple typos- fat fingers and all that.
Some links for you to have a look at…If there is no risk of disrupting the mechanism of other treatments it might shift the balance in weighing pros and cons….Not easy to make a call.I do take tumeric, probiotics and Vit D.
The trial design had patients on mebendazole for a month alternating with the antibiotic…
http://www.telegraph.co.uk/wellbeing/health-advice/crowdfunding-cure-cancer/
https://clinicaltrials.gov/ct2/show/NCT02201381?term=metformin+mebendazole&rank=1
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- January 29, 2017 at 10:19 pm
Thank so much Deb, this is great info. I've printed it off for hubby and he's looking over with interest. I am so curious as to why the trial was ended. I had assumed that atleast a fair bit of evidence would be needed to get to the stage of commencing a trial and then to end it mid recruitment seems odd. They must have struggled to get funding for it too I'm sure.
are you also in the U.K. Deb? I hope you're doing well x
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- January 29, 2017 at 10:19 pm
Thank so much Deb, this is great info. I've printed it off for hubby and he's looking over with interest. I am so curious as to why the trial was ended. I had assumed that atleast a fair bit of evidence would be needed to get to the stage of commencing a trial and then to end it mid recruitment seems odd. They must have struggled to get funding for it too I'm sure.
are you also in the U.K. Deb? I hope you're doing well x
-
- January 31, 2017 at 12:50 am
Yes am UK based. Trial suspended but only learned of it reading articles in the press during the last 6 months. Think problems are likeky to be linked to trial protocol. Too many different cancers and hard to get comparative data from untreated cohort with similar characteristics.
Patients self selecting for trial likely to be motivated and with support so may skew results ..or even if drugs are placebo like it may give other advantages.
Did get as far as researching mebendazole. Over. The counter in family packs of ovex or try a search for vermox on eBay.. Romanian suppliers very reasonable but as for quality..who knows but labelled up as big pharma product.
Recruitment for trial is patient funded and on the face if it fees are low for private consults.
I' m stage 4 and 3 doses in on IPI nivo combo after a 6 week drug holiday due to liver test showing probs. Am doiwbn to 5 mg pred. 12 week scan showed progression , but the reference scan was taken 5 weeks prior to treatment start..so waiting to see results on the next one.
All rather nerve wracking and pulledmy mood down considerably. Was hoping for something more encouraging…had dose 3 week ago today.. Itching like crazy and sunburn type rash on chest neck and face….so something is happening. Cat got double dose of spot on as thought itching could be down to her.. Ha ha..but I am only one in the family with this issue.
Best of luck to you and hubby and hope he stays Ned stage 3 forever.
Deb
-
- January 31, 2017 at 12:50 am
Yes am UK based. Trial suspended but only learned of it reading articles in the press during the last 6 months. Think problems are likeky to be linked to trial protocol. Too many different cancers and hard to get comparative data from untreated cohort with similar characteristics.
Patients self selecting for trial likely to be motivated and with support so may skew results ..or even if drugs are placebo like it may give other advantages.
Did get as far as researching mebendazole. Over. The counter in family packs of ovex or try a search for vermox on eBay.. Romanian suppliers very reasonable but as for quality..who knows but labelled up as big pharma product.
Recruitment for trial is patient funded and on the face if it fees are low for private consults.
I' m stage 4 and 3 doses in on IPI nivo combo after a 6 week drug holiday due to liver test showing probs. Am doiwbn to 5 mg pred. 12 week scan showed progression , but the reference scan was taken 5 weeks prior to treatment start..so waiting to see results on the next one.
All rather nerve wracking and pulledmy mood down considerably. Was hoping for something more encouraging…had dose 3 week ago today.. Itching like crazy and sunburn type rash on chest neck and face….so something is happening. Cat got double dose of spot on as thought itching could be down to her.. Ha ha..but I am only one in the family with this issue.
Best of luck to you and hubby and hope he stays Ned stage 3 forever.
Deb
-
- January 31, 2017 at 12:50 am
Yes am UK based. Trial suspended but only learned of it reading articles in the press during the last 6 months. Think problems are likeky to be linked to trial protocol. Too many different cancers and hard to get comparative data from untreated cohort with similar characteristics.
Patients self selecting for trial likely to be motivated and with support so may skew results ..or even if drugs are placebo like it may give other advantages.
Did get as far as researching mebendazole. Over. The counter in family packs of ovex or try a search for vermox on eBay.. Romanian suppliers very reasonable but as for quality..who knows but labelled up as big pharma product.
Recruitment for trial is patient funded and on the face if it fees are low for private consults.
I' m stage 4 and 3 doses in on IPI nivo combo after a 6 week drug holiday due to liver test showing probs. Am doiwbn to 5 mg pred. 12 week scan showed progression , but the reference scan was taken 5 weeks prior to treatment start..so waiting to see results on the next one.
All rather nerve wracking and pulledmy mood down considerably. Was hoping for something more encouraging…had dose 3 week ago today.. Itching like crazy and sunburn type rash on chest neck and face….so something is happening. Cat got double dose of spot on as thought itching could be down to her.. Ha ha..but I am only one in the family with this issue.
Best of luck to you and hubby and hope he stays Ned stage 3 forever.
Deb
-
- January 29, 2017 at 10:19 pm
Thank so much Deb, this is great info. I've printed it off for hubby and he's looking over with interest. I am so curious as to why the trial was ended. I had assumed that atleast a fair bit of evidence would be needed to get to the stage of commencing a trial and then to end it mid recruitment seems odd. They must have struggled to get funding for it too I'm sure.
are you also in the U.K. Deb? I hope you're doing well x
-
- January 29, 2017 at 5:19 pm
Hi Aval,
Was on the tablet earlier – so apologies for the multiple typos- fat fingers and all that.
Some links for you to have a look at…If there is no risk of disrupting the mechanism of other treatments it might shift the balance in weighing pros and cons….Not easy to make a call.I do take tumeric, probiotics and Vit D.
The trial design had patients on mebendazole for a month alternating with the antibiotic…
http://www.telegraph.co.uk/wellbeing/health-advice/crowdfunding-cure-cancer/
https://clinicaltrials.gov/ct2/show/NCT02201381?term=metformin+mebendazole&rank=1
-
- January 31, 2017 at 1:01 am
Oddly enough…this NPR report played as I drove to work today: http://www.npr.org/sections/health-shots/2017/01/30/512400204/a-pinworm-medication-is-being-tested-as-a-potential-anti-cancer-drug
Hmmm…. Still think Vit D, coffee, curcumin, NSAIDs have more proven human results in melanoma…and those are slim…. But!!! I have hope for anything they want to look at and see where it goes. celeste
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- January 31, 2017 at 1:01 am
Oddly enough…this NPR report played as I drove to work today: http://www.npr.org/sections/health-shots/2017/01/30/512400204/a-pinworm-medication-is-being-tested-as-a-potential-anti-cancer-drug
Hmmm…. Still think Vit D, coffee, curcumin, NSAIDs have more proven human results in melanoma…and those are slim…. But!!! I have hope for anything they want to look at and see where it goes. celeste
-
- January 31, 2017 at 1:01 am
Oddly enough…this NPR report played as I drove to work today: http://www.npr.org/sections/health-shots/2017/01/30/512400204/a-pinworm-medication-is-being-tested-as-a-potential-anti-cancer-drug
Hmmm…. Still think Vit D, coffee, curcumin, NSAIDs have more proven human results in melanoma…and those are slim…. But!!! I have hope for anything they want to look at and see where it goes. celeste
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- January 31, 2017 at 8:10 pm
thabks very much for this. We had a listen…. interesting! I am amazed that the drug has increased that much America! Here in UK it's £6 for a pack of 4. Paul (hubby) is taking circumin, is v.healthy and exercises lots. So really he's doing everything he can do (possibly) reduce risk of recurrence. He's decided to take mebendazole for a month. He's under no allusion… this Bugar will do what it wants… but hey, could be worth a go so long as no side effects. Atleast he'all have a nice parasitic free bowel!
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- January 31, 2017 at 8:10 pm
thabks very much for this. We had a listen…. interesting! I am amazed that the drug has increased that much America! Here in UK it's £6 for a pack of 4. Paul (hubby) is taking circumin, is v.healthy and exercises lots. So really he's doing everything he can do (possibly) reduce risk of recurrence. He's decided to take mebendazole for a month. He's under no allusion… this Bugar will do what it wants… but hey, could be worth a go so long as no side effects. Atleast he'all have a nice parasitic free bowel!
-
- January 31, 2017 at 8:10 pm
thabks very much for this. We had a listen…. interesting! I am amazed that the drug has increased that much America! Here in UK it's £6 for a pack of 4. Paul (hubby) is taking circumin, is v.healthy and exercises lots. So really he's doing everything he can do (possibly) reduce risk of recurrence. He's decided to take mebendazole for a month. He's under no allusion… this Bugar will do what it wants… but hey, could be worth a go so long as no side effects. Atleast he'all have a nice parasitic free bowel!
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