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MDX-1105

Forums General Melanoma Community MDX-1105

  • Post
    joy_
    Participant

      My husband was hoping to qualify for the Derma study, but we found out today that he didn't.  He's currently stage IIIc and we are looking into other treatment options.  This looks to be a Phase 1 study, and I am curious if anyone out there knows anything about it or has received this treatment.  I've searched the board and couldn't find anything about it.  Maybe it is known by another name?

      Tracy

      My husband was hoping to qualify for the Derma study, but we found out today that he didn't.  He's currently stage IIIc and we are looking into other treatment options.  This looks to be a Phase 1 study, and I am curious if anyone out there knows anything about it or has received this treatment.  I've searched the board and couldn't find anything about it.  Maybe it is known by another name?

      Tracy

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    • Replies
        Tim–MRF
        Guest

          Tracy:

          I have spoken with GSK, the company doing the study, about this and it sounds interesting to me.  It is a vaccine study, and is sometimes referred to with the term MAGE-A3.  The idea is to use tumor tissue to create an antigenic agent that will stimulate the body's immune system to attack residual tumor cells.

          The study focuses on patients for whom observation is the standard of care, and is divided into an arm that receives the vaccine and a group that receives placebo.  Using placebo in cancer trials is rare, but is acceptable in this case because the standard of care is observation.

          I like that it offers some possible treatment for people who are told not to have any further treatment, but who feel as though they want to do something.

          I also like that it is a vaccine.  Most vaccines haven't worked in melanoma, but some are now showing a bit of promise.  Some data released a few months ago suggest that every melanoma cell acts like a stem cell and can form a new tumor.  If that is the case, then having the immune system set up to sweep out remaining tumor cells is not a bad thing.

          Tim–MRF

           

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          joy_
          Participant

            Tim,

            Thank you for taking time to reply to my post, your remarks are exactly why we were excited about this trial.  Unfortunately my husband did not qualify for the GSK Derma study because he tested negative for MAGE-A3.  This is why I'm hoping someone will have a little experience or info on the Phase 1 trial using MDX-1105.  That's pretty much his only option unless he can get into the Ipi vs. placebo trial for those with stage III.

            Best,

            Tracy

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            jim Breitfeller
            Participant

               

              1106 and 105 target different parts of  a T cell inhibitory pathway, known as the PD-1 pathway.  PD-1 causes T cells to die and the partner molecule which triggers this (PD-L1, PD-1 ligand) is expressed by many melanomas. So, from the melanoma cell’s perspective, this is a strong self-defense pathway which causes the T cell to die when it encounters a melanoma cell. 1106 has been used more (so far) in melanoma and the results presented by our group and others at ASCO clearly show that 1106 has clinical activity in melanoma.  There is a phase 1 trial combining 1106 with ipi to see how safe it is to block 2 inhibitory pathways (CTLA-4 and PD-1).(at Yale and SLoan Kettering)

              Catherine M. Poole, President/Founder

              Melanoma International Foundation

              The MIF Website and Forums are designed for educational purposes only and are not engaged in rendering medical advice or professional services. The information provided through this Website should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, you should consult your health care provider.

               

                Re: anti PD-1 MDX 1106/MDX 1105 BMS (alankravitz)
              Posted: 2:44:20 pm on 8/16/2010 Modified: Never

              I just posted for the first time today and am willing to share my experience with this immunotherapy about which there is very little public information due to its early stage of development, I am now in my 12 TH cycle, the last in this Phase 1B trial. My prior treatment was IL-2 to which I did not respond. I have had a partial response at the lowest of  the three dossage levels in the trial and have not had any significant side effects beyond some fatigue and a rash that responded very quickley when I was allowed a steroidal cream. I am in communication with several other patients at various locations who report positive results at all levels of treatment and at the other participating institutions as well as Yale where I am enrolled. Those of us involved in this and other related trials need to communicate with each other and with others who might benefit. We need to work together to insure that Bristol Meyers increase its efforts to develop the drug for both Melanoma and RCC where it shows considerable promise. We also need to work to insure that those, including myself, who have responded to treatment are able to recieve some form of continuing treatment without having to wait for a new threat. This last point is especailly important to those who have been through muntiple therapies that have not yielded durable responses.

               

              Jimmy B

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                joy_
                Participant

                  Thanks, Jimmy!

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