My husband was diagnosed with Stage 4 metastatic ocular (uveal) melanoma in Dec 2011. By the time he was diangnosed it had affected a large part of his liver but was not in any other area of his body. He started seeing Dr. Richard Carvajal at MSKCC in NYC in January and began a trial medication in February – AZD 6244 in February. He began to feel better almost immediately – the pain disappreared, better appetite, more energy – but in subsequent scans the tumor was not shrinking so three weeks ago they took him off the med and since then he is declining rapidly. The reason they took him offf the trial med is because the criteria for testing was tumor shrinkage so it almost didn't matter that he felt better. He is due to start Yervoy this coming Tuesday and we are hopeful that may have some good results. I have also done some reading about the combination of Yervoy and radiation which has been in the news recently and there is hope there – although I haven't asked the Dr. about that yet.. Anyway, is there anyone out there who is also struggling with this type of melanoma – the ocular one that my husband Neil has? That has metastasized to the liver? Does anyone know about the combination of Yervoy and radiation or another treatments that we could look into? I would so apprecaite hearing back from you. This disease is a terrifying monster and I so want to find something tthat will help him. Susan Morse
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