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Leukine-not effective, published study at ASCO

This topic has 2 replies, 1 voice, and was last updated 14 years, 1 month ago by killmel.

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- November 2, 2010 at 3:46 pm
- Quote
killmel
Participant
E4697: Phase III cooperative group study of yeast-derived granulocyte macrophage colony-stimulating factor (GM-CSF) versus placebo as adjuvant treatment of patients with completely resected stage III-IV melanoma.

This is an ECOG study begun in 2006 to see if SQ GM-CSF is an effective adjuvant treatment in patients with resectable metastatic disease, after surgery. The primary endpoint was overall survival which at the time of the abstract’s writing (updates for ASCO are suggested in the text) was NOT met, meaning that overall the drug was not effective. PFS (progression free survival) was positive statistically but only 3 months difference.

full abstract link:
http://abstract.asco.org/AbstView_74_49374.html

I found this entry on a website maintained by Eric Whitman a melanoma expert at Atlantic Melanoma Center:The updated data for this trial was all negative.

E4697: Phase III cooperative group study of yeast-derived granulocyte macrophage colony-stimulating factor (GM-CSF) versus placebo as adjuvant treatment of patients with completely resected stage III-IV melanoma.

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- - November 2, 2010 at 3:48 pm
  - Quote
  killmel
  Participant
  I have had 2 recurrence while taking leukine for almost 1 year so I guess it did not work 🙁 I have read other post that people have had recurrences as well
- - November 2, 2010 at 3:48 pm
  - Quote
  killmel
  Participant
  I have had 2 recurrence while taking leukine for almost 1 year so I guess it did not work 🙁 I have read other post that people have had recurrences as well

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Leukine-not effective, published study at ASCO

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