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Leukine & interaction with Lisinopril (Zestril) and/or Hydrochlorothiazid
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Leukine & interaction with Lisinopril (Zestril) and/or Hydrochlorothiazid

› Forums › General Melanoma Community › Leukine & interaction with Lisinopril (Zestril) and/or Hydrochlorothiazid

  • Post
    • March 4, 2011 at 3:08 am
    jbergman
    Participant

      Hello Everyone,

      Hello Everyone,

      Bernhard just completed his second round of leukine on March 1.  A blood test taken to monitor his potassium level (high) showed something new = a creatinine level of 5.85; it was 1.3 January 19, before he started round one of leukine.  This creatinine level indicates possible kidney failure, B is in the hospital now getting the kidneys hydrated, and the condition reversed, we hope.  All doctors have stopped the two medications B has taken for years for hypertension and the next round of leukine may be delayed until more is known. 

      So, does anyone have any experience with leukine and either of these two drugs, Lisinopril/Zestril, or Hydrochlorothiazid?  The doctors are stumped.

      Thanks for any advice, experiences.

      Julia

    Viewing 1 reply thread
    • Replies
        • March 6, 2011 at 2:53 am
        Rocklove
        Participant

          Julia I had similar problems with Leukine and Lisinipril. My creatinine level was normally around 1.0, but after treatment it raised to 3.3. It took about 6 months to get the level back under 1.5. The other day it was 1.3 and that was 6.5 months. So it has not got to my normal level yet. I am told it is trending down and that is a good thing. Basically wait and see.

          The doctors were not alarmed…………I was… It really did scare me. I also called a friend of mine that just had a kidney transplant and quized her. She said the creatinine level works differant on many people. She had no pain or problems and her level was over 5………Some people have a lot of pain and problems and there level is 3.

          Hopefully Bernhard will see his level decrease soon and the doctors get to the bottom of it.

          Good Luck… Positive Prayers and Thoughts to both of you.

          Rocky (Stage IV Liver Mets)

            • March 6, 2011 at 3:06 am
            jbergman
            Participant

              Hello Rocky,

              Many, many thanks for your response!  We were feeling so stranded without any information to help us understand what was going on.  We still don't know excatly what is going on, but at least there is one other person who has been there too.

              We are in northern California and will drive down to San Francisco tomorrow to meet with Dr. Alain Algazi at the Melanoma Clinic at University of California, San Francisco.  May we share your email with him?

              I see your name all over this website – thank you for  taking the time to share information (I'm a librarian, so I REALLY appreciate your contributions).

              Onwards,

              Julia

              • March 6, 2011 at 1:19 pm
              Rocklove
              Participant

                Julia you are more than welcome to share my notes with anyone. Hope it helps. I thought my 3.3 was alarming. Make sure you leave no stones unturned with this creatinine level… until both of you feel comfortable.

                Rocky

                • March 6, 2011 at 1:19 pm
                Rocklove
                Participant

                  Julia you are more than welcome to share my notes with anyone. Hope it helps. I thought my 3.3 was alarming. Make sure you leave no stones unturned with this creatinine level… until both of you feel comfortable.

                  Rocky

                  • March 6, 2011 at 3:06 am
                  jbergman
                  Participant

                    Hello Rocky,

                    Many, many thanks for your response!  We were feeling so stranded without any information to help us understand what was going on.  We still don't know excatly what is going on, but at least there is one other person who has been there too.

                    We are in northern California and will drive down to San Francisco tomorrow to meet with Dr. Alain Algazi at the Melanoma Clinic at University of California, San Francisco.  May we share your email with him?

                    I see your name all over this website – thank you for  taking the time to share information (I'm a librarian, so I REALLY appreciate your contributions).

                    Onwards,

                    Julia

                  • March 6, 2011 at 2:53 am
                  Rocklove
                  Participant

                    Julia I had similar problems with Leukine and Lisinipril. My creatinine level was normally around 1.0, but after treatment it raised to 3.3. It took about 6 months to get the level back under 1.5. The other day it was 1.3 and that was 6.5 months. So it has not got to my normal level yet. I am told it is trending down and that is a good thing. Basically wait and see.

                    The doctors were not alarmed…………I was… It really did scare me. I also called a friend of mine that just had a kidney transplant and quized her. She said the creatinine level works differant on many people. She had no pain or problems and her level was over 5………Some people have a lot of pain and problems and there level is 3.

                    Hopefully Bernhard will see his level decrease soon and the doctors get to the bottom of it.

                    Good Luck… Positive Prayers and Thoughts to both of you.

                    Rocky (Stage IV Liver Mets)

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