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Knee Pain…
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Knee Pain…

› Forums › General Melanoma Community › Knee Pain…

  • Post
    • August 24, 2017 at 3:43 pm
    Megara984
    Participant

      Hey all. My husband just started having really bad knee pain behind his left knee. He's had some pain there before being diagnosed with melanoma. I'm wondering if the Opdivo/Yervoy is making it worse? He taking a low dose of Advil or Tylonel to help. Has anyone experienced this? Is it a side effect? Or is it the immunotherapy working on his bones. (His Melanoma is in his bone to some extent). Thanks. 

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        • August 24, 2017 at 4:24 pm
        betsyl
        Participant

          Yes, I believe joint pain is a common side effect. I think it's caused by inflammation. My husband has hip and knee pain from Keytruda. 🙁

           

          • August 24, 2017 at 5:43 pm
          cancersnewnormal
          Participant

            Inflammation and arthritis can be a side effect of immunotherapy meds. Definitely something to discuss with his oncologist. The first place I felt it take hold was at the site of an old neck injury. Docs can do some blood work to check his inflammation markers, and may want to get x-ray, CT, or MRI of his knee, for confirmation… or even just to rule out other possibilites. Advil is ibuprofin and will have anti-inflammatory effects if that is causing his pain. Naproxen (Aleve is one brand name) may be even more effective than Advil, but can sometimes be harder on the stomach. Inflammation aside, if his tumor was invading the bone, and the immuno combo begins to effectively shrink lesions…. he may feel some pain from that as well. 

              • August 24, 2017 at 6:18 pm
              Megara984
              Participant

                Thank you both… now my next question… he is also sweating when he takes any of these (Advil or tylonel) any thoughts or ideas of what could be causing that? We have an oncologist appointment on Monday. So we'll be bringing a lot of this up. 

                • August 25, 2017 at 2:24 pm
                cancersnewnormal
                Participant

                  Huh. That's a new one for me. I've never heard of that issue before. I had to Google it. Not that Dr. Google is always equipping us with accurate answers, but I did find a site that lists both meds in the top 12 that can cause sweating. http://www.skincareguide.com/article/skin-conditions/other-conditions/12-medications-that-cause-excessive-sweating   Has he had this issue in the past? … prior to diagnosis?

                  • August 25, 2017 at 8:03 pm
                  Megara984
                  Participant

                    He did have nightsweats leading up to the diagnosis. But they stopped the minute he started immunotherapy. We think it might have something to do with his Spleen… that is the one organ aside from lymph nodes that's affected.

                  • August 25, 2017 at 3:27 pm
                  Nicklindner
                  Participant

                    My right knee really hurts for about 48-72 hours after my nivo infusion.  As others have said I believe this is a more common side effect. 

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