› Forums › General Melanoma Community › keytruda cross blood-brain barrier
- This topic has 18 replies, 4 voices, and was last updated 8 years, 5 months ago by
triciad.
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- October 26, 2015 at 12:31 am
Sorry for what's going on…hate it. I'm not all that knowledgeable on Keytruda but based on what I've read, it does cross blood brain barrier. Hang in there…options are available!
Josh
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- October 26, 2015 at 12:47 am
Yes and no. Celeste has a gazillion articles on her blog.
Basically if I remember right it doesn't have to. The keytruda and opdivo pd1 float around until they detect a white blood cell. Then it attaches and dissolves the pd1 protein. Now that is an activated tcell. It floats around all over including the brain. Hopefully it then detects the cancer cells it was blinded by before and no more tumor.
When I was on keytruda I had one of three tumors pressing on my brain radiated. Kind of odd the two non radiated virtually disappeared which was wonderful. Unfortunately I've still got the radiated one.
But you should get a head MRI now if you haven't cause if they are there and caught early it's usually easier to gamma knife or something.
Artie
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- October 26, 2015 at 10:43 pm
Artie,
Thanks again for the wonderful advice. I'm so happy to hear that the two disappeared, and I pray the last one will go away, too.
I thought the same thing about the brain MRI. I was surprised my doctor did not send me for one. My old oncologist did. I will ask tomorrow. I'm much rather catch it while I can.
Blessings to you,
Tricia
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- October 26, 2015 at 10:43 pm
Artie,
Thanks again for the wonderful advice. I'm so happy to hear that the two disappeared, and I pray the last one will go away, too.
I thought the same thing about the brain MRI. I was surprised my doctor did not send me for one. My old oncologist did. I will ask tomorrow. I'm much rather catch it while I can.
Blessings to you,
Tricia
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- October 26, 2015 at 10:43 pm
Artie,
Thanks again for the wonderful advice. I'm so happy to hear that the two disappeared, and I pray the last one will go away, too.
I thought the same thing about the brain MRI. I was surprised my doctor did not send me for one. My old oncologist did. I will ask tomorrow. I'm much rather catch it while I can.
Blessings to you,
Tricia
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- October 26, 2015 at 12:47 am
Yes and no. Celeste has a gazillion articles on her blog.
Basically if I remember right it doesn't have to. The keytruda and opdivo pd1 float around until they detect a white blood cell. Then it attaches and dissolves the pd1 protein. Now that is an activated tcell. It floats around all over including the brain. Hopefully it then detects the cancer cells it was blinded by before and no more tumor.
When I was on keytruda I had one of three tumors pressing on my brain radiated. Kind of odd the two non radiated virtually disappeared which was wonderful. Unfortunately I've still got the radiated one.
But you should get a head MRI now if you haven't cause if they are there and caught early it's usually easier to gamma knife or something.
Artie
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- October 26, 2015 at 12:47 am
Yes and no. Celeste has a gazillion articles on her blog.
Basically if I remember right it doesn't have to. The keytruda and opdivo pd1 float around until they detect a white blood cell. Then it attaches and dissolves the pd1 protein. Now that is an activated tcell. It floats around all over including the brain. Hopefully it then detects the cancer cells it was blinded by before and no more tumor.
When I was on keytruda I had one of three tumors pressing on my brain radiated. Kind of odd the two non radiated virtually disappeared which was wonderful. Unfortunately I've still got the radiated one.
But you should get a head MRI now if you haven't cause if they are there and caught early it's usually easier to gamma knife or something.
Artie
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- October 26, 2015 at 1:51 am
Hi Tricia,
Sorry for all that you are going through. Artie had it right. Here is a post that gives an overview of how anti-PD1 (be it Nivo/Opdivo or Pembro/Keytruda) work: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/anti-pd1-in-melanoma-t-cells-brain-and.html
There is a great deal more related info on my blog….if you are interested…just use the search bubble in the top left corner.
I want to echo what Mat said in your previous post…I don't think you need to make radical decisions just yet. You have only had one anti-Pd1 infusion. Give it a minute and see what happens. I worked throughout my 2 1/2 years on Nivo/Opdivo…although my situation was not nearly as complicated as yours. For those issues, I would completely rely on Artie…he is an amazing guy and a personal hero of mine, having dealt with way more than his fair share of areas of metastasis and pain.
My daugher is a teacher. You are a special breed and I suspect I know what you are thinking on behalf of your students. Take a minute. Maybe think about making a work decision around Christmas or Spring break? That would give you time to assess your response to anti-PD1 and any side effects related to the med or your tumor burden. Hang in there. I wish you my best. Celeste
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- October 26, 2015 at 10:50 pm
Celeste,
Your blog is AMAZING!!! Kuddos to you for your knowlege and dedication to share this incredible information.
I'm happy to hear that you worked through a similar treatment. I'm going to give it my best shot. I just don't want to let my little cherubs (or their families) down. Hopefully, after my 4th infusion, I will have positive results and I will laugh at all of the dark places my mind has traveled over the past few days!
Thank God I have all of you to shine some light and help me through the dark spots.
In the thunderstorm of life…you all are life's rainbows! My sincerest thanks!!!!
Tricia
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- October 26, 2015 at 10:50 pm
Celeste,
Your blog is AMAZING!!! Kuddos to you for your knowlege and dedication to share this incredible information.
I'm happy to hear that you worked through a similar treatment. I'm going to give it my best shot. I just don't want to let my little cherubs (or their families) down. Hopefully, after my 4th infusion, I will have positive results and I will laugh at all of the dark places my mind has traveled over the past few days!
Thank God I have all of you to shine some light and help me through the dark spots.
In the thunderstorm of life…you all are life's rainbows! My sincerest thanks!!!!
Tricia
-
- October 26, 2015 at 10:50 pm
Celeste,
Your blog is AMAZING!!! Kuddos to you for your knowlege and dedication to share this incredible information.
I'm happy to hear that you worked through a similar treatment. I'm going to give it my best shot. I just don't want to let my little cherubs (or their families) down. Hopefully, after my 4th infusion, I will have positive results and I will laugh at all of the dark places my mind has traveled over the past few days!
Thank God I have all of you to shine some light and help me through the dark spots.
In the thunderstorm of life…you all are life's rainbows! My sincerest thanks!!!!
Tricia
-
- October 26, 2015 at 1:51 am
Hi Tricia,
Sorry for all that you are going through. Artie had it right. Here is a post that gives an overview of how anti-PD1 (be it Nivo/Opdivo or Pembro/Keytruda) work: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/anti-pd1-in-melanoma-t-cells-brain-and.html
There is a great deal more related info on my blog….if you are interested…just use the search bubble in the top left corner.
I want to echo what Mat said in your previous post…I don't think you need to make radical decisions just yet. You have only had one anti-Pd1 infusion. Give it a minute and see what happens. I worked throughout my 2 1/2 years on Nivo/Opdivo…although my situation was not nearly as complicated as yours. For those issues, I would completely rely on Artie…he is an amazing guy and a personal hero of mine, having dealt with way more than his fair share of areas of metastasis and pain.
My daugher is a teacher. You are a special breed and I suspect I know what you are thinking on behalf of your students. Take a minute. Maybe think about making a work decision around Christmas or Spring break? That would give you time to assess your response to anti-PD1 and any side effects related to the med or your tumor burden. Hang in there. I wish you my best. Celeste
-
- October 26, 2015 at 1:51 am
Hi Tricia,
Sorry for all that you are going through. Artie had it right. Here is a post that gives an overview of how anti-PD1 (be it Nivo/Opdivo or Pembro/Keytruda) work: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/anti-pd1-in-melanoma-t-cells-brain-and.html
There is a great deal more related info on my blog….if you are interested…just use the search bubble in the top left corner.
I want to echo what Mat said in your previous post…I don't think you need to make radical decisions just yet. You have only had one anti-Pd1 infusion. Give it a minute and see what happens. I worked throughout my 2 1/2 years on Nivo/Opdivo…although my situation was not nearly as complicated as yours. For those issues, I would completely rely on Artie…he is an amazing guy and a personal hero of mine, having dealt with way more than his fair share of areas of metastasis and pain.
My daugher is a teacher. You are a special breed and I suspect I know what you are thinking on behalf of your students. Take a minute. Maybe think about making a work decision around Christmas or Spring break? That would give you time to assess your response to anti-PD1 and any side effects related to the med or your tumor burden. Hang in there. I wish you my best. Celeste
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