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Keytruda and Gleevec combination therapy side effects?
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Keytruda and Gleevec combination therapy side effects?

› Forums › Mucosal Melanoma Community › Keytruda and Gleevec combination therapy side effects?

  • Post
    • March 10, 2016 at 7:58 am
    chrisholder
    Participant

      Hello,all,

      Just finished a seven week course of IMRT radiation therapy in conjuncition with Pembrolizumab (Keytruda) for my mucosal melanoma tumor in the maxillary sinus.  Now with radiation over, docs are considering continuing the Keytruda and – since I am positive for the cKIT mutation – adding Gleevec (imatinib), but we're worried aout the possible side effects.  Anyone have experience with this combination and side effects?  Everyone is afraid I would be in a "clinical trial of one."

    Viewing 2 reply threads
    • Replies
        • May 22, 2016 at 12:58 pm
        garretda
        Participant

          Approximately 7 months on pembrolizumab and imatinib –  fatigue has been the most noticeable side effect.  Pruritus, itchy skin, was also an issue initially, but has appeared to subside somewhat.

            • August 30, 2016 at 11:40 am
            gliderdp
            Participant

              Hi,

              I have been on Imatinib for 4 years for CML and Pembrolizumab for 4 weeks for stage 4 melanoma. Maybe 1st person in UK being treated with both drugs? So far no serious side effects – occasional nausea, some diarrhoea, intermittent fatigue, no skin issues – main problem is backache, but I think this is caused by diverticulosis

              Regards

              David Powell

              • May 3, 2018 at 12:08 pm
              dlmccue
              Participant

                Good morning. How are you doing on the keytruda and gleevec. I have been using gleevec for 5 weeks and plan to add keytruda. We are not finding any research on mixing these two drugs and am wondering how you tolerated the combination.

                Thank you.

                Regards, Joe McCue

                • May 3, 2018 at 12:27 pm
                dlmccue
                Participant

                  Good morning. I plan to follow this combination in two weeks. Can you tell me how it went? I to have been told I will be the only one.

                   

                  • August 30, 2016 at 11:40 am
                  gliderdp
                  Participant

                    Hi,

                    I have been on Imatinib for 4 years for CML and Pembrolizumab for 4 weeks for stage 4 melanoma. Maybe 1st person in UK being treated with both drugs? So far no serious side effects – occasional nausea, some diarrhoea, intermittent fatigue, no skin issues – main problem is backache, but I think this is caused by diverticulosis

                    Regards

                    David Powell

                    • August 30, 2016 at 11:40 am
                    gliderdp
                    Participant

                      Hi,

                      I have been on Imatinib for 4 years for CML and Pembrolizumab for 4 weeks for stage 4 melanoma. Maybe 1st person in UK being treated with both drugs? So far no serious side effects – occasional nausea, some diarrhoea, intermittent fatigue, no skin issues – main problem is backache, but I think this is caused by diverticulosis

                      Regards

                      David Powell

                    • May 22, 2016 at 12:58 pm
                    garretda
                    Participant

                      Approximately 7 months on pembrolizumab and imatinib –  fatigue has been the most noticeable side effect.  Pruritus, itchy skin, was also an issue initially, but has appeared to subside somewhat.

                      • May 22, 2016 at 12:58 pm
                      garretda
                      Participant

                        Approximately 7 months on pembrolizumab and imatinib –  fatigue has been the most noticeable side effect.  Pruritus, itchy skin, was also an issue initially, but has appeared to subside somewhat.

                    Viewing 2 reply threads

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