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I’ve started a CDK 4/6 Dual Inhibitor Trial!
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I’ve started a CDK 4/6 Dual Inhibitor Trial!

› Forums › General Melanoma Community › I’ve started a CDK 4/6 Dual Inhibitor Trial!

  • Post
    • May 18, 2012 at 6:13 pm
    tim duduit
    Participant

      My tumor is in a lymph node adjacent to my adrenal gland; got the results confirming metastatic malignancy 2 weeks ago and started the clinical trial this week.  I'm on the medication full time now and haven't had any side effects. I'm still struggling with the diagnosis because I don't feel sick.  I still fee funny going in the door to the treatment room because I'm thinking "I'm in here with the sick people!"  Anyone else on this kind of trial drug?

      My tumor is in a lymph node adjacent to my adrenal gland; got the results confirming metastatic malignancy 2 weeks ago and started the clinical trial this week.  I'm on the medication full time now and haven't had any side effects. I'm still struggling with the diagnosis because I don't feel sick.  I still fee funny going in the door to the treatment room because I'm thinking "I'm in here with the sick people!"  Anyone else on this kind of trial drug?

    Viewing 5 reply threads
    • Replies
        • May 18, 2012 at 8:21 pm
        rbruce
        Participant

          I haven't heard of this trial.  What hospital/drug company is hosting the trial? Robert

            • May 19, 2012 at 12:05 am
            tim duduit
            Participant

              It is a study funded by Eli Lily Company and is being administered by the START cancer center here in San Antonio.

              • May 21, 2012 at 4:57 am
              rbruce
              Participant

                Tim,  can you share why your Dr. felt this was a good trial for you? Are you braf +?  My side effects on Anti-pd1 were non existant until my 6th infusion, then fatigue, muscle and bone pains set in, still very manageable. How often do you get the drug? Is it infusion or oral?  Any side effects yet?  When is your next pet/ct? Hope you have great results.  

                Thanks!  Robert 

                • May 21, 2012 at 4:57 am
                rbruce
                Participant

                  Tim,  can you share why your Dr. felt this was a good trial for you? Are you braf +?  My side effects on Anti-pd1 were non existant until my 6th infusion, then fatigue, muscle and bone pains set in, still very manageable. How often do you get the drug? Is it infusion or oral?  Any side effects yet?  When is your next pet/ct? Hope you have great results.  

                  Thanks!  Robert 

                  • May 21, 2012 at 8:43 pm
                  tim duduit
                  Participant

                    Robert, I am not BRAF+. My oncologist suggested the trial because the tumor is in a lymph node between the adrenal gland and my spine.  Surgery would be major and would leave me waiting for the next tumor.  The genetic analysis of my tumor showed that my tumor is positive for the CDKN2A and ATK3 mutations and would be suseptible to CDK4/6 inhibitors and AKT inhibitors.  So I began the trial for the CDK inhibitor last thursday using the drug Tarceva (currently approved for use in a certain type of lung and pancreatic cancer).  I take the drug orally morning and evening and I will take it for 8 weeks and then have a PET scan to see if the tumor responded.  If the tumor shirnks or stays the same size, I will continue to take the drug because there is a benefit.  If it has gotten bigger, then we will talk about switching me to the AKT inhibitor.  The study is funded by Eli Lily and there is no time limit as long as I'm recieving a benefit from one of the two drugs.  No side effects yet.  Good luck with your tumor, too.

                    • January 30, 2013 at 8:00 pm
                    abecker
                    Participant

                      I know I am coming in late to this discussion, but is that trial still ongoing and what was your experience with this drug.

                      • January 30, 2013 at 8:00 pm
                      abecker
                      Participant

                        I know I am coming in late to this discussion, but is that trial still ongoing and what was your experience with this drug.

                        • January 30, 2013 at 8:00 pm
                        abecker
                        Participant

                          I know I am coming in late to this discussion, but is that trial still ongoing and what was your experience with this drug.

                          • May 21, 2012 at 8:43 pm
                          tim duduit
                          Participant

                            Robert, I am not BRAF+. My oncologist suggested the trial because the tumor is in a lymph node between the adrenal gland and my spine.  Surgery would be major and would leave me waiting for the next tumor.  The genetic analysis of my tumor showed that my tumor is positive for the CDKN2A and ATK3 mutations and would be suseptible to CDK4/6 inhibitors and AKT inhibitors.  So I began the trial for the CDK inhibitor last thursday using the drug Tarceva (currently approved for use in a certain type of lung and pancreatic cancer).  I take the drug orally morning and evening and I will take it for 8 weeks and then have a PET scan to see if the tumor responded.  If the tumor shirnks or stays the same size, I will continue to take the drug because there is a benefit.  If it has gotten bigger, then we will talk about switching me to the AKT inhibitor.  The study is funded by Eli Lily and there is no time limit as long as I'm recieving a benefit from one of the two drugs.  No side effects yet.  Good luck with your tumor, too.

                            • May 21, 2012 at 8:43 pm
                            tim duduit
                            Participant

                              Robert, I am not BRAF+. My oncologist suggested the trial because the tumor is in a lymph node between the adrenal gland and my spine.  Surgery would be major and would leave me waiting for the next tumor.  The genetic analysis of my tumor showed that my tumor is positive for the CDKN2A and ATK3 mutations and would be suseptible to CDK4/6 inhibitors and AKT inhibitors.  So I began the trial for the CDK inhibitor last thursday using the drug Tarceva (currently approved for use in a certain type of lung and pancreatic cancer).  I take the drug orally morning and evening and I will take it for 8 weeks and then have a PET scan to see if the tumor responded.  If the tumor shirnks or stays the same size, I will continue to take the drug because there is a benefit.  If it has gotten bigger, then we will talk about switching me to the AKT inhibitor.  The study is funded by Eli Lily and there is no time limit as long as I'm recieving a benefit from one of the two drugs.  No side effects yet.  Good luck with your tumor, too.

                              • May 21, 2012 at 4:57 am
                              rbruce
                              Participant

                                Tim,  can you share why your Dr. felt this was a good trial for you? Are you braf +?  My side effects on Anti-pd1 were non existant until my 6th infusion, then fatigue, muscle and bone pains set in, still very manageable. How often do you get the drug? Is it infusion or oral?  Any side effects yet?  When is your next pet/ct? Hope you have great results.  

                                Thanks!  Robert 

                                • May 19, 2012 at 12:05 am
                                tim duduit
                                Participant

                                  It is a study funded by Eli Lily Company and is being administered by the START cancer center here in San Antonio.

                                  • May 19, 2012 at 12:05 am
                                  tim duduit
                                  Participant

                                    It is a study funded by Eli Lily Company and is being administered by the START cancer center here in San Antonio.

                                  • May 18, 2012 at 8:21 pm
                                  rbruce
                                  Participant

                                    I haven't heard of this trial.  What hospital/drug company is hosting the trial? Robert

                                    • May 18, 2012 at 8:21 pm
                                    rbruce
                                    Participant

                                      I haven't heard of this trial.  What hospital/drug company is hosting the trial? Robert

                                      • December 6, 2013 at 8:10 pm
                                      Scuba Doc
                                      Participant

                                        I have metastasized melanoma in the lungs with brain leasions ( had radiosurgery ) Starting a clinical trial       ( Dana Faber , Boston ) soon with the drug —LEE011 –by Novartis. Question —Has anyone had any experience with this drug as far as the severity of the side effects. I also have secondary progressive MS which makes me inelligible for many other clinical trials. —-ty —-Linda

                                        • December 6, 2013 at 8:10 pm
                                        Scuba Doc
                                        Participant

                                          I have metastasized melanoma in the lungs with brain leasions ( had radiosurgery ) Starting a clinical trial       ( Dana Faber , Boston ) soon with the drug —LEE011 –by Novartis. Question —Has anyone had any experience with this drug as far as the severity of the side effects. I also have secondary progressive MS which makes me inelligible for many other clinical trials. —-ty —-Linda

                                          • December 6, 2013 at 8:10 pm
                                          Scuba Doc
                                          Participant

                                            I have metastasized melanoma in the lungs with brain leasions ( had radiosurgery ) Starting a clinical trial       ( Dana Faber , Boston ) soon with the drug —LEE011 –by Novartis. Question —Has anyone had any experience with this drug as far as the severity of the side effects. I also have secondary progressive MS which makes me inelligible for many other clinical trials. —-ty —-Linda

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