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Iritus as side effect to Tafinlar
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Iritus as side effect to Tafinlar

› Forums › General Melanoma Community › Iritus as side effect to Tafinlar

  • Post
    • September 15, 2015 at 3:52 am
    Rita and Charles
    Participant

      Hey there, my husband has been having great results on the braf combo trametinib/tafinlar – from his June PET to his late August CT, his lung tuomor shrunk by half, lymph nodes regressed and no new tumors in his lung. Yay!  Recently though his left ey has gone completely fuzzy, he can't see out of it.  After going to his opthamologist today he learned he as Iritus – evidently 1% of people have eye side effects.

      He has been prescribed a steroid eye drop, we haven't heard from his oncologist yet if this will in anyway affect his tafinlar usage. We don't want to stop or stall using the combo – it is working.

      Any similar findings out there??

      Thanks, Rita

    Viewing 2 reply threads
    • Replies
        • September 15, 2015 at 1:34 pm
        marta010
        Participant

          Hi Rita – my husband has had several bouts with another type of eye inflamation – uveitis – while on tafinlar.  He has been successfully treated with steriod eye drops (Durezol) without interruption in his tafinlar treatment.  His opthamologist agrees that the uveitis is a side effect of the tafinlar and that we have a fine line to walk between treating the underlying disease and managing the side effects.  Sending prayers your way.

           

          Ann

            • September 23, 2015 at 12:23 am
            wasserd
            Participant
              I am on same combo and just diagnosed today with my third case of iritis in less than two months! The first time I was on dabrafenib only and the onset was much more severe. The past two times I have been on the combo and less painful, still super annoying. My ophthalmologist has me using prednisone eye drops but also keeping my pupil dilated by using dilating drops three times a day (cyclopentolate hydrochloride). He told me that if it persists, I may need to stay on a regimen of steroid drops twice a day, which eventually can lead to cataracts, but that this would obviously be preferable to going off the cancer meds! For the time being, my oncologist has ordered a two week hiatus from the cancer meds for me, which has helped manage side effects in the past. (It stays in the body for about ten days.)

              I hope the condition improves soon!

              Deborah

              • September 23, 2015 at 12:23 am
              wasserd
              Participant
                I am on same combo and just diagnosed today with my third case of iritis in less than two months! The first time I was on dabrafenib only and the onset was much more severe. The past two times I have been on the combo and less painful, still super annoying. My ophthalmologist has me using prednisone eye drops but also keeping my pupil dilated by using dilating drops three times a day (cyclopentolate hydrochloride). He told me that if it persists, I may need to stay on a regimen of steroid drops twice a day, which eventually can lead to cataracts, but that this would obviously be preferable to going off the cancer meds! For the time being, my oncologist has ordered a two week hiatus from the cancer meds for me, which has helped manage side effects in the past. (It stays in the body for about ten days.)

                I hope the condition improves soon!

                Deborah

                • September 23, 2015 at 12:23 am
                wasserd
                Participant
                  I am on same combo and just diagnosed today with my third case of iritis in less than two months! The first time I was on dabrafenib only and the onset was much more severe. The past two times I have been on the combo and less painful, still super annoying. My ophthalmologist has me using prednisone eye drops but also keeping my pupil dilated by using dilating drops three times a day (cyclopentolate hydrochloride). He told me that if it persists, I may need to stay on a regimen of steroid drops twice a day, which eventually can lead to cataracts, but that this would obviously be preferable to going off the cancer meds! For the time being, my oncologist has ordered a two week hiatus from the cancer meds for me, which has helped manage side effects in the past. (It stays in the body for about ten days.)

                  I hope the condition improves soon!

                  Deborah

                • September 15, 2015 at 1:34 pm
                marta010
                Participant

                  Hi Rita – my husband has had several bouts with another type of eye inflamation – uveitis – while on tafinlar.  He has been successfully treated with steriod eye drops (Durezol) without interruption in his tafinlar treatment.  His opthamologist agrees that the uveitis is a side effect of the tafinlar and that we have a fine line to walk between treating the underlying disease and managing the side effects.  Sending prayers your way.

                   

                  Ann

                  • September 15, 2015 at 1:34 pm
                  marta010
                  Participant

                    Hi Rita – my husband has had several bouts with another type of eye inflamation – uveitis – while on tafinlar.  He has been successfully treated with steriod eye drops (Durezol) without interruption in his tafinlar treatment.  His opthamologist agrees that the uveitis is a side effect of the tafinlar and that we have a fine line to walk between treating the underlying disease and managing the side effects.  Sending prayers your way.

                     

                    Ann

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