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Ipi side effects
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Ipi side effects

› Forums › General Melanoma Community › Ipi side effects

  • Post
    • March 3, 2014 at 1:42 pm
    heiditemple
    Participant

      I just had my second infusion of 10 mg/kg ipi last Tuesday.  After my first infusion, I had very few side effects.. just a tiny bit of itchiness and very sporadic diarrhea.  Almost immediately after my second infusion, I developed a rash on the inside of my arm and I have been itching all over my body pretty much non-stop.  I know this is a fairly common side effect, so I'm not worried about it.  However, I was taking a shower yesterday in lukewarm water.  For some reason, my hands started feeling like they were on fire.. maybe nerve issues?  Is this something I should report to my doctor?  

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    • Replies
        • March 3, 2014 at 2:47 pm
        Brendan
        Participant

          Hi Heidi,

          Sorry to hear about your hands.  I think anything 'strange' should be reported to you oncologist.  Good luck.

          Brendan

            • March 3, 2014 at 9:25 pm
            arthurjedi007
            Participant

              Yes report it to your Dr I would think. Also at 10mg you must be in a trial or non USA I would think because 3mg per kg is all I could get here. So definitely at that dosage I would believe you should report anything unusual.

              • March 3, 2014 at 9:25 pm
              arthurjedi007
              Participant

                Yes report it to your Dr I would think. Also at 10mg you must be in a trial or non USA I would think because 3mg per kg is all I could get here. So definitely at that dosage I would believe you should report anything unusual.

                • March 3, 2014 at 9:25 pm
                arthurjedi007
                Participant

                  Yes report it to your Dr I would think. Also at 10mg you must be in a trial or non USA I would think because 3mg per kg is all I could get here. So definitely at that dosage I would believe you should report anything unusual.

                • March 3, 2014 at 2:47 pm
                Brendan
                Participant

                  Hi Heidi,

                  Sorry to hear about your hands.  I think anything 'strange' should be reported to you oncologist.  Good luck.

                  Brendan

                  • March 3, 2014 at 2:47 pm
                  Brendan
                  Participant

                    Hi Heidi,

                    Sorry to hear about your hands.  I think anything 'strange' should be reported to you oncologist.  Good luck.

                    Brendan

                    • March 4, 2014 at 1:06 pm
                    Rocco
                    Participant

                      Hi Heidi –

                      I would encourage you to report all of these symptoms.  I was on 10mg/kg years ago when Ipi was in a Phase III trial prior to it going FDA approved at 3mg.  It's worth keeping your doctor/your medical team up to date on all of your symptoms.

                      Wishing you well with Ipi!

                      Rocco, IV since 2005, NED thanks to Ipi

                      • March 4, 2014 at 1:06 pm
                      Rocco
                      Participant

                        Hi Heidi –

                        I would encourage you to report all of these symptoms.  I was on 10mg/kg years ago when Ipi was in a Phase III trial prior to it going FDA approved at 3mg.  It's worth keeping your doctor/your medical team up to date on all of your symptoms.

                        Wishing you well with Ipi!

                        Rocco, IV since 2005, NED thanks to Ipi

                        • March 4, 2014 at 1:06 pm
                        Rocco
                        Participant

                          Hi Heidi –

                          I would encourage you to report all of these symptoms.  I was on 10mg/kg years ago when Ipi was in a Phase III trial prior to it going FDA approved at 3mg.  It's worth keeping your doctor/your medical team up to date on all of your symptoms.

                          Wishing you well with Ipi!

                          Rocco, IV since 2005, NED thanks to Ipi

                          • March 5, 2014 at 6:50 am
                          Marianne quinn
                          Participant

                            Hi Heidi- I was wondering how you were doing. . My husband is getting his fourth 10 mg ipi tomorrow . Start taking Benadryl  now for the rash. He stopped for a couple of days and diarrhea started. He still has the rash but it is not too bothersome with taking the Benadryl daily. He had some bad bouts of abdominal pain after the 3 rd dose. We discovered he cannot have milk or ice cream  although cheese and yogurt are fine.  I hope you have some immodium on hand too because you should jump on the diarrhea quickly if you get it. 

                            he is really doing well. I didn't mean to scare you. His labs are all normal and no GI problems since stopping  milk.  He has had a warm feeling on his arm but it has lessened.. I will be so glad when this infduction phase is over.

                            • March 5, 2014 at 6:50 am
                            Marianne quinn
                            Participant

                              Hi Heidi- I was wondering how you were doing. . My husband is getting his fourth 10 mg ipi tomorrow . Start taking Benadryl  now for the rash. He stopped for a couple of days and diarrhea started. He still has the rash but it is not too bothersome with taking the Benadryl daily. He had some bad bouts of abdominal pain after the 3 rd dose. We discovered he cannot have milk or ice cream  although cheese and yogurt are fine.  I hope you have some immodium on hand too because you should jump on the diarrhea quickly if you get it. 

                              he is really doing well. I didn't mean to scare you. His labs are all normal and no GI problems since stopping  milk.  He has had a warm feeling on his arm but it has lessened.. I will be so glad when this infduction phase is over.

                              • March 5, 2014 at 6:50 am
                              Marianne quinn
                              Participant

                                Hi Heidi- I was wondering how you were doing. . My husband is getting his fourth 10 mg ipi tomorrow . Start taking Benadryl  now for the rash. He stopped for a couple of days and diarrhea started. He still has the rash but it is not too bothersome with taking the Benadryl daily. He had some bad bouts of abdominal pain after the 3 rd dose. We discovered he cannot have milk or ice cream  although cheese and yogurt are fine.  I hope you have some immodium on hand too because you should jump on the diarrhea quickly if you get it. 

                                he is really doing well. I didn't mean to scare you. His labs are all normal and no GI problems since stopping  milk.  He has had a warm feeling on his arm but it has lessened.. I will be so glad when this infduction phase is over.

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