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IPI or PLX4032?-Please Advise!

Forums General Melanoma Community IPI or PLX4032?-Please Advise!

  • Post
    adgesoph
    Participant

      My dad has stage 1V melanoma (braf positive), just finished up 2 rounds of Interleukin-2 and it didn't work (no real surprise there) so now his doctor is looking into either ipi or PLX4032.  Which one is best?  Pros and Cons?  What would you do if you were in his shoes?   I want to help my dad anyway I can and need to know the ins and outs of all this stuff so we can make the best choice.  Please help!

      My dad has stage 1V melanoma (braf positive), just finished up 2 rounds of Interleukin-2 and it didn't work (no real surprise there) so now his doctor is looking into either ipi or PLX4032.  Which one is best?  Pros and Cons?  What would you do if you were in his shoes?   I want to help my dad anyway I can and need to know the ins and outs of all this stuff so we can make the best choice.  Please help!  Thank you!

       

      Adrienne

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        KatyWI
        Participant

          Oh, but there is no "best" choice!  There's only his choice.  Treatment decisions are very personal & like someone here taught me, once you make your choice, you never look back.

          that being said, both BRAF and Ipi were considerations for me.  I chose ipi for my current treatment.  The chief advantage I saw was that some responses are durable with ipi, although CR is about as rare as with IL-2.  Also, I have a good history with immunotherapy (responsed to IL-2, did well on interferon when I was stage III), so that seemed like a good approach for me.  Finally, Ipi is believed to have some efficacy in the brain, and I do have brain mets.

          those are a very few of the considerations for ME – for your dad they will be different.  Learn about likelihood of response, learn about side effects, and then…never look back!

          Good luck

          KatyWI

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          KatyWI
          Participant

            Oh, but there is no "best" choice!  There's only his choice.  Treatment decisions are very personal & like someone here taught me, once you make your choice, you never look back.

            that being said, both BRAF and Ipi were considerations for me.  I chose ipi for my current treatment.  The chief advantage I saw was that some responses are durable with ipi, although CR is about as rare as with IL-2.  Also, I have a good history with immunotherapy (responsed to IL-2, did well on interferon when I was stage III), so that seemed like a good approach for me.  Finally, Ipi is believed to have some efficacy in the brain, and I do have brain mets.

            those are a very few of the considerations for ME – for your dad they will be different.  Learn about likelihood of response, learn about side effects, and then…never look back!

            Good luck

            KatyWI

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            sukie53
            Participant

              Hi Adrienne,

              I am so sorry to hear about your Dad, it's great that he has you looking into all this for you so that he can just concentrate on fighting this disease.

              This would be my opinion, although utlimately there is no right or wrong decision I don't think. I am on plx. It worked remarkabley quickly and has improved my quality of life amazingly in the 4 months I have been on it. I haven't posted very much here so if you search under sukie53 you should be able to read my other posts. The side effects aren't too bad at all, so if your Dad's disease is well advanced and his life expectancy is short, I would go for plx first becuase it has an 80% response rate and it happens quickly. . Also, if he is poorly following the Il 2 it will give him a chance to regain his strength. Plx does fail quite quickly in some people so maybe that would be the time to move on to ipi.

              However, if your Dad is quite fit and his disease is not too far progressed, he might be better starting with ipi. It can be very slow to work, but the side effects can be more serious I believe. I haven't tried this yet though so I cannot really say much about it.

              For me, plx has been an amazing drug, which brought me from the brink of death, so I am bound to ne biased!

              Let me know if you need any more info,

              xSukie

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              sukie53
              Participant

                Hi Adrienne,

                I am so sorry to hear about your Dad, it's great that he has you looking into all this for you so that he can just concentrate on fighting this disease.

                This would be my opinion, although utlimately there is no right or wrong decision I don't think. I am on plx. It worked remarkabley quickly and has improved my quality of life amazingly in the 4 months I have been on it. I haven't posted very much here so if you search under sukie53 you should be able to read my other posts. The side effects aren't too bad at all, so if your Dad's disease is well advanced and his life expectancy is short, I would go for plx first becuase it has an 80% response rate and it happens quickly. . Also, if he is poorly following the Il 2 it will give him a chance to regain his strength. Plx does fail quite quickly in some people so maybe that would be the time to move on to ipi.

                However, if your Dad is quite fit and his disease is not too far progressed, he might be better starting with ipi. It can be very slow to work, but the side effects can be more serious I believe. I haven't tried this yet though so I cannot really say much about it.

                For me, plx has been an amazing drug, which brought me from the brink of death, so I am bound to ne biased!

                Let me know if you need any more info,

                xSukie

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                  JerryfromFauq
                  Participant

                    Suki, Sounds like good reasoning to me.

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                    JerryfromFauq
                    Participant

                      Suki, Sounds like good reasoning to me.

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                    sukie53
                    Participant

                      Hi Adrienne,

                      I am so sorry to hear about your Dad, it's great that he has you looking into all this for you so that he can just concentrate on fighting this disease.

                      This would be my opinion, although utlimately there is no right or wrong decision I don't think. I am on plx. It worked remarkabley quickly and has improved my quality of life amazingly in the 4 months I have been on it. I haven't posted very much here so if you search under sukie53 you should be able to read my other posts. The side effects aren't too bad at all, so if your Dad's disease is well advanced and his life expectancy is short, I would go for plx first becuase it has an 80% response rate and it happens quickly. . Also, if he is poorly following the Il 2 it will give him a chance to regain his strength. Plx does fail quite quickly in some people so maybe that would be the time to move on to ipi.

                      However, if your Dad is quite fit and his disease is not too far progressed, he might be better starting with ipi. It can be very slow to work, but the side effects can be more serious I believe. I haven't tried this yet though so I cannot really say much about it.

                      For me, plx has been an amazing drug, which brought me from the brink of death, so I am bound to ne biased!

                      Let me know if you need any more info,

                      xSukie

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                      sukie53
                      Participant

                        Hi Adrienne,

                        I am so sorry to hear about your Dad, it's great that he has you looking into all this for you so that he can just concentrate on fighting this disease.

                        This would be my opinion, although utlimately there is no right or wrong decision I don't think. I am on plx. It worked remarkabley quickly and has improved my quality of life amazingly in the 4 months I have been on it. I haven't posted very much here so if you search under sukie53 you should be able to read my other posts. The side effects aren't too bad at all, so if your Dad's disease is well advanced and his life expectancy is short, I would go for plx first becuase it has an 80% response rate and it happens quickly. . Also, if he is poorly following the Il 2 it will give him a chance to regain his strength. Plx does fail quite quickly in some people so maybe that would be the time to move on to ipi.

                        However, if your Dad is quite fit and his disease is not too far progressed, he might be better starting with ipi. It can be very slow to work, but the side effects can be more serious I believe. I haven't tried this yet though so I cannot really say much about it.

                        For me, plx has been an amazing drug, which brought me from the brink of death, so I am bound to ne biased!

                        Let me know if you need any more info,

                        xSukie

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