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Infusion reaction
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Infusion reaction

› Forums › General Melanoma Community › Infusion reaction

  • Post
    • July 19, 2016 at 8:23 pm
    Aaron
    Participant

      Getting my opdivo half of my treatments today and got warm sensation accompanied by rash during treatment.  Got a bunch of benedryl, Pepcid and something else.  No we are pushing the meds at 1/2 the rate 

    Viewing 8 reply threads
    • Replies
        • July 19, 2016 at 9:04 pm
        Polymath
        Participant

          Hi Aaron,

          Actually, I think a bit of a rash, and/or allergic type reaction is a good thing.  As the meds ramp up your immune system your body may become over-sensitive to any number of things.  It points to an immune response and while not a guarantee of the response we all hope for, its a good sign and a very manageable side-effect.  Keep us posted.

          Gary

          • July 19, 2016 at 9:04 pm
          Polymath
          Participant

            Hi Aaron,

            Actually, I think a bit of a rash, and/or allergic type reaction is a good thing.  As the meds ramp up your immune system your body may become over-sensitive to any number of things.  It points to an immune response and while not a guarantee of the response we all hope for, its a good sign and a very manageable side-effect.  Keep us posted.

            Gary

            • July 19, 2016 at 9:04 pm
            Polymath
            Participant

              Hi Aaron,

              Actually, I think a bit of a rash, and/or allergic type reaction is a good thing.  As the meds ramp up your immune system your body may become over-sensitive to any number of things.  It points to an immune response and while not a guarantee of the response we all hope for, its a good sign and a very manageable side-effect.  Keep us posted.

              Gary

              • July 19, 2016 at 10:18 pm
              jade1111
              Participant

                Sorry about the rash!! My mom just had her first infusion and its 10 days later and got a very bad rash all over. She is hesistant (I know ironic) about taing claritin for it. Did Benedryl help you? I am not sure what the mechanism is for it. She has never taken anitihistamine and is nervous..

                Wishing you all the best with infusions!

                • July 19, 2016 at 10:18 pm
                jade1111
                Participant

                  Sorry about the rash!! My mom just had her first infusion and its 10 days later and got a very bad rash all over. She is hesistant (I know ironic) about taing claritin for it. Did Benedryl help you? I am not sure what the mechanism is for it. She has never taken anitihistamine and is nervous..

                  Wishing you all the best with infusions!

                  • July 19, 2016 at 10:18 pm
                  jade1111
                  Participant

                    Sorry about the rash!! My mom just had her first infusion and its 10 days later and got a very bad rash all over. She is hesistant (I know ironic) about taing claritin for it. Did Benedryl help you? I am not sure what the mechanism is for it. She has never taken anitihistamine and is nervous..

                    Wishing you all the best with infusions!

                    • July 19, 2016 at 10:51 pm
                    KAF
                    Participant

                      HI Aaron

                      Its Karen again.  Hard to believe we were just messaging 48hrs ago that we weren't having symtoms and were worried about that.  🙂

                      Did you get through the Yervoy part first an then got the reaction half way through Opdivo or did you not to the Yervoy yet?  I got my rash after 7 days after my first treatment.  Benadryl didn't work but I used Sarna lotion  and although I smelled like Vicks vapo rub it really took the itch away.  My friend who's a pediatrician told me to ask for Atarax (like a prescrption strength benadryl) and the rash went away by the next day.  I then got a rash a week later, took the atarax that evening and it was gone by morning.  Haven't had it since.  

                      Just becuase you had that reaction this time doesn't mean you'll have it every time.  These drugs seem so random when it comes to side affects.  Take it slow on the intake this time and hopefully it won't happen next time.  Just one more to go!!!  Hang in there.

                      Karen 

                        • July 19, 2016 at 11:50 pm
                        Aaron
                        Participant

                          Hot flashes started at the end of opdivo but went away.  Halfway through yervoy they returned with a vengeance. Felt like getting the dye during a scan (very warm). Then the rash came on. They shut me down and gave me the Benadryl etc and took my vitals for about an hour until everything went away. Then resumed at a slower infusion rate. Made for a long day. Now we have to wait and see what happens next time but I think I am going to bet some Benadryl before I go home. 

                          • July 19, 2016 at 11:53 pm
                          jennunicorn
                          Participant

                            Next time ask for benedryl before your infusion starts. I am sure they will already want to do that based on today, but if they don't mention it, I would ask. A lot of people take it before infusions to prevent these kind of reactions.

                            • July 19, 2016 at 11:53 pm
                            jennunicorn
                            Participant

                              Next time ask for benedryl before your infusion starts. I am sure they will already want to do that based on today, but if they don't mention it, I would ask. A lot of people take it before infusions to prevent these kind of reactions.

                              • July 19, 2016 at 11:53 pm
                              jennunicorn
                              Participant

                                Next time ask for benedryl before your infusion starts. I am sure they will already want to do that based on today, but if they don't mention it, I would ask. A lot of people take it before infusions to prevent these kind of reactions.

                                • July 19, 2016 at 11:50 pm
                                Aaron
                                Participant

                                  Hot flashes started at the end of opdivo but went away.  Halfway through yervoy they returned with a vengeance. Felt like getting the dye during a scan (very warm). Then the rash came on. They shut me down and gave me the Benadryl etc and took my vitals for about an hour until everything went away. Then resumed at a slower infusion rate. Made for a long day. Now we have to wait and see what happens next time but I think I am going to bet some Benadryl before I go home. 

                                  • July 19, 2016 at 11:50 pm
                                  Aaron
                                  Participant

                                    Hot flashes started at the end of opdivo but went away.  Halfway through yervoy they returned with a vengeance. Felt like getting the dye during a scan (very warm). Then the rash came on. They shut me down and gave me the Benadryl etc and took my vitals for about an hour until everything went away. Then resumed at a slower infusion rate. Made for a long day. Now we have to wait and see what happens next time but I think I am going to bet some Benadryl before I go home. 

                                  • July 19, 2016 at 10:51 pm
                                  KAF
                                  Participant

                                    HI Aaron

                                    Its Karen again.  Hard to believe we were just messaging 48hrs ago that we weren't having symtoms and were worried about that.  🙂

                                    Did you get through the Yervoy part first an then got the reaction half way through Opdivo or did you not to the Yervoy yet?  I got my rash after 7 days after my first treatment.  Benadryl didn't work but I used Sarna lotion  and although I smelled like Vicks vapo rub it really took the itch away.  My friend who's a pediatrician told me to ask for Atarax (like a prescrption strength benadryl) and the rash went away by the next day.  I then got a rash a week later, took the atarax that evening and it was gone by morning.  Haven't had it since.  

                                    Just becuase you had that reaction this time doesn't mean you'll have it every time.  These drugs seem so random when it comes to side affects.  Take it slow on the intake this time and hopefully it won't happen next time.  Just one more to go!!!  Hang in there.

                                    Karen 

                                    • July 19, 2016 at 10:51 pm
                                    KAF
                                    Participant

                                      HI Aaron

                                      Its Karen again.  Hard to believe we were just messaging 48hrs ago that we weren't having symtoms and were worried about that.  🙂

                                      Did you get through the Yervoy part first an then got the reaction half way through Opdivo or did you not to the Yervoy yet?  I got my rash after 7 days after my first treatment.  Benadryl didn't work but I used Sarna lotion  and although I smelled like Vicks vapo rub it really took the itch away.  My friend who's a pediatrician told me to ask for Atarax (like a prescrption strength benadryl) and the rash went away by the next day.  I then got a rash a week later, took the atarax that evening and it was gone by morning.  Haven't had it since.  

                                      Just becuase you had that reaction this time doesn't mean you'll have it every time.  These drugs seem so random when it comes to side affects.  Take it slow on the intake this time and hopefully it won't happen next time.  Just one more to go!!!  Hang in there.

                                      Karen 

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