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I have a few questions!!
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I have a few questions!!

› Forums › General Melanoma Community › I have a few questions!!

  • Post
    • September 5, 2014 at 12:02 pm
    eturner
    Participant

      Hi everyone,

      My husband went to the dr on Tuesday and  we now know that the Braf combo drug has stopped working… While on the Braf drug his bone mets did not disappear they just stopped growing and his pain stopped during this time as well…. On the MRI this week it showed his L5 has a burst fracture and a large met in his hip area (radiation starts today on that) next week he will begin Ipi. My questions are he had many many bone mets to his spine, hip and pelvis as well as a deep femur met, and some on his skull, Is Ipi a good med for many bone mets and since the mets never went away after taking the Braf drug will they become active once again? Just looking for others experiences and advice. It means so much getting your advice.

    Viewing 2 reply threads
    • Replies
        • September 5, 2014 at 12:16 pm
        jualonso
        Participant

          Well, as far as i know, Ipi enhance your inmune system and it can get to anywhere, even bone mets. But i think that radiation plus IPI use to be better if you also consider the abscopal effect.

           

          Hope to be helpfull

            • September 5, 2014 at 4:20 pm
            arthurjedi007
            Participant

              Exactly. If the ctla4 pathway is a way for the ipi t-cells to get into the tumor then your husband will be a responder to ipi and voila the tumors shrink whether bone or not. I did not respond to ipi but the pd1 pathway via pembro has been good so far and the couple dozen tumors I have pretty much all involve bone.

              Also yes exactly immunotherapies like ipi and pd1 can work better with radiation. For example starting ipi within 24 to 48 hours after receiving the last radiation dose seems to be something I read as ideal. I'm not sure but I also assume already being fully immersed in the ipi or pd1 like I've read after the 3rd dose of ipi to then hit with the radiation is also ideal. But everyone is different.

              Artie

              • September 5, 2014 at 4:20 pm
              arthurjedi007
              Participant

                Exactly. If the ctla4 pathway is a way for the ipi t-cells to get into the tumor then your husband will be a responder to ipi and voila the tumors shrink whether bone or not. I did not respond to ipi but the pd1 pathway via pembro has been good so far and the couple dozen tumors I have pretty much all involve bone.

                Also yes exactly immunotherapies like ipi and pd1 can work better with radiation. For example starting ipi within 24 to 48 hours after receiving the last radiation dose seems to be something I read as ideal. I'm not sure but I also assume already being fully immersed in the ipi or pd1 like I've read after the 3rd dose of ipi to then hit with the radiation is also ideal. But everyone is different.

                Artie

                • September 5, 2014 at 4:20 pm
                arthurjedi007
                Participant

                  Exactly. If the ctla4 pathway is a way for the ipi t-cells to get into the tumor then your husband will be a responder to ipi and voila the tumors shrink whether bone or not. I did not respond to ipi but the pd1 pathway via pembro has been good so far and the couple dozen tumors I have pretty much all involve bone.

                  Also yes exactly immunotherapies like ipi and pd1 can work better with radiation. For example starting ipi within 24 to 48 hours after receiving the last radiation dose seems to be something I read as ideal. I'm not sure but I also assume already being fully immersed in the ipi or pd1 like I've read after the 3rd dose of ipi to then hit with the radiation is also ideal. But everyone is different.

                  Artie

                • September 5, 2014 at 12:16 pm
                jualonso
                Participant

                  Well, as far as i know, Ipi enhance your inmune system and it can get to anywhere, even bone mets. But i think that radiation plus IPI use to be better if you also consider the abscopal effect.

                   

                  Hope to be helpfull

                  • September 5, 2014 at 12:16 pm
                  jualonso
                  Participant

                    Well, as far as i know, Ipi enhance your inmune system and it can get to anywhere, even bone mets. But i think that radiation plus IPI use to be better if you also consider the abscopal effect.

                     

                    Hope to be helpfull

                Viewing 2 reply threads
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