› Forums › General Melanoma Community › help with pathology report
- This topic has 45 replies, 4 voices, and was last updated 11 years, 8 months ago by jfro.
- Post
-
- September 4, 2012 at 5:54 pm
Hello!
I was hoping someone could help me decipher my pathology report. My diagnosis seems a bit rare and doesn't seem related to melanoma but I tend to get very nervous right away. I'd appreciate any help from any kind hearted soul out there.
Diagnosis: Melanocytic Nevus, intradermal type, with focal atypia
Clinical Data: Pearly Papulr R/O Squamous Cell Carcinoma
pecimen Site: Right elbow-shave biopsy
Gross Description: This specimen is a portion of skin measuring (mm) 4×3, 1pc.
Hello!
I was hoping someone could help me decipher my pathology report. My diagnosis seems a bit rare and doesn't seem related to melanoma but I tend to get very nervous right away. I'd appreciate any help from any kind hearted soul out there.
Diagnosis: Melanocytic Nevus, intradermal type, with focal atypia
Clinical Data: Pearly Papulr R/O Squamous Cell Carcinoma
pecimen Site: Right elbow-shave biopsy
Gross Description: This specimen is a portion of skin measuring (mm) 4×3, 1pc.
Microscopic Description:
Present within the dermis are orderly nests, cords, and strands of melanocytic nevus cells. There is focial atypia present. There is melanin pigmentation present. HMB 45 shows some superficial staning, Ki-67 stains rare singe cells in the lesion. P-16 also shows some scattered positivity. If this is a smaller portion of a larger lesion or recurs, complete removal is recommended to ensure full histologic evaluation.Okay-so I'm freaking out a bit! Could this come back melanoma once looked at again??
Thank you.
- Replies
-
-
- September 4, 2012 at 6:22 pm
Unlikely. It would have helped if you could have included the final diagnosis, however. I believe the recommendation to remove more is likely based on the extremely small tissue sample removed.They want to make sure the rest of the sample looks similar. It appears the portion removed has some atypical cells but nothing “sinister”.-
- September 4, 2012 at 8:37 pm
The stains are designed to make melanocytes show up in a tissue sample, that's all. Sometimes multiple stains are used to make sure that all cells are "illuminated". Without staining, it is much harder to read a pathology slide and look for melanocytes.
It sounds like with the diagnosis that this may have mild atypia. Focal means in the central part of the lesion. This also means that outside the center, the cells show no atypia. In general, many doctors wouldn't even remove the lesion to get clear margins. I do believe that the tiny sample size is the reason they are asking for removal – the pathologist can't be certain there isn't something else there. However, pathologists often cover their tracks by asking for more removal – just in case. I, personally, would not be worried about the next removal in the least given the previous diagnosis. And I also agree that shave biopsies – while easy for the doctor – are the best choice for the patient.
-
- September 4, 2012 at 9:35 pm
Thank you, Janner.
Now looking at my lesion. It seems that it was cut in half. The entire lesion was 5mm and it looks as though 2 mm is left. Do you think this will change the diagnosis? (I'm sorry if this sounds like me being an alarmist!)
Also, the part that says If this is a smaller portion of a larger lesion or recurs, complete removal is recommended to ensure full histologic evaluation. Is this indicated because they aren't sure what it is?
Thanks!
-
- September 4, 2012 at 10:07 pm
The lesion is basically benign. Do I think looking at the rest of the lesion will change this? Extremely unlikely. This is a cover your A$$ situation — the pathologist is saying that there is more left behind and complete removal is needed to make sure there isn't anything sinister there. They've already made a diagnosis which is benign. They know what it is, they just haven't seen all of it. I'd say the likelihood of the remainder of the lesion being anything other than what was removed before is EXTREMELY unlikely. DO NOT WORRY ABOUT THIS – there is nothing to worry about with this lesion. This is just doctor's being careful in a society that likes to sue. Remove everything "to be sure", but I wouldn't spend another minute on this site as it is totally unnecessary! This lesion is not melanoma, and the remaining portion is not melanoma. There's not much more that can be said.
-
- September 4, 2012 at 10:07 pm
The lesion is basically benign. Do I think looking at the rest of the lesion will change this? Extremely unlikely. This is a cover your A$$ situation — the pathologist is saying that there is more left behind and complete removal is needed to make sure there isn't anything sinister there. They've already made a diagnosis which is benign. They know what it is, they just haven't seen all of it. I'd say the likelihood of the remainder of the lesion being anything other than what was removed before is EXTREMELY unlikely. DO NOT WORRY ABOUT THIS – there is nothing to worry about with this lesion. This is just doctor's being careful in a society that likes to sue. Remove everything "to be sure", but I wouldn't spend another minute on this site as it is totally unnecessary! This lesion is not melanoma, and the remaining portion is not melanoma. There's not much more that can be said.
-
- September 4, 2012 at 10:07 pm
The lesion is basically benign. Do I think looking at the rest of the lesion will change this? Extremely unlikely. This is a cover your A$$ situation — the pathologist is saying that there is more left behind and complete removal is needed to make sure there isn't anything sinister there. They've already made a diagnosis which is benign. They know what it is, they just haven't seen all of it. I'd say the likelihood of the remainder of the lesion being anything other than what was removed before is EXTREMELY unlikely. DO NOT WORRY ABOUT THIS – there is nothing to worry about with this lesion. This is just doctor's being careful in a society that likes to sue. Remove everything "to be sure", but I wouldn't spend another minute on this site as it is totally unnecessary! This lesion is not melanoma, and the remaining portion is not melanoma. There's not much more that can be said.
-
- September 4, 2012 at 9:35 pm
Thank you, Janner.
Now looking at my lesion. It seems that it was cut in half. The entire lesion was 5mm and it looks as though 2 mm is left. Do you think this will change the diagnosis? (I'm sorry if this sounds like me being an alarmist!)
Also, the part that says If this is a smaller portion of a larger lesion or recurs, complete removal is recommended to ensure full histologic evaluation. Is this indicated because they aren't sure what it is?
Thanks!
-
- September 4, 2012 at 9:35 pm
Thank you, Janner.
Now looking at my lesion. It seems that it was cut in half. The entire lesion was 5mm and it looks as though 2 mm is left. Do you think this will change the diagnosis? (I'm sorry if this sounds like me being an alarmist!)
Also, the part that says If this is a smaller portion of a larger lesion or recurs, complete removal is recommended to ensure full histologic evaluation. Is this indicated because they aren't sure what it is?
Thanks!
-
- September 4, 2012 at 8:37 pm
The stains are designed to make melanocytes show up in a tissue sample, that's all. Sometimes multiple stains are used to make sure that all cells are "illuminated". Without staining, it is much harder to read a pathology slide and look for melanocytes.
It sounds like with the diagnosis that this may have mild atypia. Focal means in the central part of the lesion. This also means that outside the center, the cells show no atypia. In general, many doctors wouldn't even remove the lesion to get clear margins. I do believe that the tiny sample size is the reason they are asking for removal – the pathologist can't be certain there isn't something else there. However, pathologists often cover their tracks by asking for more removal – just in case. I, personally, would not be worried about the next removal in the least given the previous diagnosis. And I also agree that shave biopsies – while easy for the doctor – are the best choice for the patient.
-
- September 4, 2012 at 8:37 pm
The stains are designed to make melanocytes show up in a tissue sample, that's all. Sometimes multiple stains are used to make sure that all cells are "illuminated". Without staining, it is much harder to read a pathology slide and look for melanocytes.
It sounds like with the diagnosis that this may have mild atypia. Focal means in the central part of the lesion. This also means that outside the center, the cells show no atypia. In general, many doctors wouldn't even remove the lesion to get clear margins. I do believe that the tiny sample size is the reason they are asking for removal – the pathologist can't be certain there isn't something else there. However, pathologists often cover their tracks by asking for more removal – just in case. I, personally, would not be worried about the next removal in the least given the previous diagnosis. And I also agree that shave biopsies – while easy for the doctor – are the best choice for the patient.
-
- September 4, 2012 at 6:22 pm
Unlikely. It would have helped if you could have included the final diagnosis, however. I believe the recommendation to remove more is likely based on the extremely small tissue sample removed.They want to make sure the rest of the sample looks similar. It appears the portion removed has some atypical cells but nothing “sinister”. -
- September 4, 2012 at 6:22 pm
Unlikely. It would have helped if you could have included the final diagnosis, however. I believe the recommendation to remove more is likely based on the extremely small tissue sample removed.They want to make sure the rest of the sample looks similar. It appears the portion removed has some atypical cells but nothing “sinister”. -
- September 4, 2012 at 6:30 pm
Please be aware that I am not a doctor, so take my words for what they are worth.
A "nevus" is the medical term for a mole. Melanocytes are normal skin cells that contain melanin; they expand in the sun and give you a tan. So you have a dark-colored mole. Under the microscope and with special stains, there are some "funny-looking" spots (focial atypia) but nothing too alarming. The foci could be pre-squamous cell cancer, but there is no indication of malignant melanoma. However, if they only removed part of the mole, or if it comes back, they should make sure to remove all of it just to be safe. OK?
By the way, I would never let anyone remove ANY "suspicious lesion" from my skin using a shave biopsy. They MUST perform a punch biopsy. If (God forbid) the lesion turns out to be malignant melanoma, they MUST get a depth of lesion to correctly stage the cancer. With a shave biopsy, they can't determine the depth of the lesion (which is why my brother is currently Stage IV with brain mets).
-
- September 4, 2012 at 6:30 pm
Please be aware that I am not a doctor, so take my words for what they are worth.
A "nevus" is the medical term for a mole. Melanocytes are normal skin cells that contain melanin; they expand in the sun and give you a tan. So you have a dark-colored mole. Under the microscope and with special stains, there are some "funny-looking" spots (focial atypia) but nothing too alarming. The foci could be pre-squamous cell cancer, but there is no indication of malignant melanoma. However, if they only removed part of the mole, or if it comes back, they should make sure to remove all of it just to be safe. OK?
By the way, I would never let anyone remove ANY "suspicious lesion" from my skin using a shave biopsy. They MUST perform a punch biopsy. If (God forbid) the lesion turns out to be malignant melanoma, they MUST get a depth of lesion to correctly stage the cancer. With a shave biopsy, they can't determine the depth of the lesion (which is why my brother is currently Stage IV with brain mets).
-
- September 4, 2012 at 6:37 pm
POW-
I appreciate the time you took to explain that to me. I did not know that about a shave, I will be sure to not allow that at any other time!!
This may sound crazy but how possible is it for the second report to show something different as the first? Most of the mole was taken. There is only a little part left. Thanks!
-
- September 4, 2012 at 6:37 pm
POW-
I appreciate the time you took to explain that to me. I did not know that about a shave, I will be sure to not allow that at any other time!!
This may sound crazy but how possible is it for the second report to show something different as the first? Most of the mole was taken. There is only a little part left. Thanks!
-
- September 4, 2012 at 6:37 pm
POW-
I appreciate the time you took to explain that to me. I did not know that about a shave, I will be sure to not allow that at any other time!!
This may sound crazy but how possible is it for the second report to show something different as the first? Most of the mole was taken. There is only a little part left. Thanks!
-
- September 4, 2012 at 6:30 pm
Please be aware that I am not a doctor, so take my words for what they are worth.
A "nevus" is the medical term for a mole. Melanocytes are normal skin cells that contain melanin; they expand in the sun and give you a tan. So you have a dark-colored mole. Under the microscope and with special stains, there are some "funny-looking" spots (focial atypia) but nothing too alarming. The foci could be pre-squamous cell cancer, but there is no indication of malignant melanoma. However, if they only removed part of the mole, or if it comes back, they should make sure to remove all of it just to be safe. OK?
By the way, I would never let anyone remove ANY "suspicious lesion" from my skin using a shave biopsy. They MUST perform a punch biopsy. If (God forbid) the lesion turns out to be malignant melanoma, they MUST get a depth of lesion to correctly stage the cancer. With a shave biopsy, they can't determine the depth of the lesion (which is why my brother is currently Stage IV with brain mets).
-
- September 4, 2012 at 6:44 pm
I am impressed by your biopsy report and its use of antigin staining results…so much more advanced then my initial biopsy was. Perhaps this www could give you some understanding http://www.ventana.com/product/121?type=115
Just wait for the results…its very early regardless of the diagnosis.Wondering why you say its's rare? Did your oncologist give you a name for it?
-
- September 4, 2012 at 6:44 pm
I am impressed by your biopsy report and its use of antigin staining results…so much more advanced then my initial biopsy was. Perhaps this www could give you some understanding http://www.ventana.com/product/121?type=115
Just wait for the results…its very early regardless of the diagnosis.Wondering why you say its's rare? Did your oncologist give you a name for it?
-
- September 4, 2012 at 7:05 pm
POW-The mole is going to be excised again to make sure everything is taken. So I was wondering about that next report. What is it looking for?
Also-I am not seeing an oncologist. I have not been diagnosed with anything. I Just had a mole taken off a few weeks ago from my regular derm.
-
- September 4, 2012 at 7:34 pm
Oh. I see. Well, it seems to me that you're on the right track (remember, I'm not a doctor). The pathologist said that if they had not removed all of the mole, they should go back and get the rest of it. So that's what your doctor is going to do. They will probably send this specimen to the pathologist, too, to make sure (under the microscope) that the whole thing has been removed (i.e., the margins are clear). That all sounds good.
And you are correct. Since you have not been diagonosed with malignant melanoma you don't need to see an oncologist.
-
- September 4, 2012 at 7:34 pm
Oh. I see. Well, it seems to me that you're on the right track (remember, I'm not a doctor). The pathologist said that if they had not removed all of the mole, they should go back and get the rest of it. So that's what your doctor is going to do. They will probably send this specimen to the pathologist, too, to make sure (under the microscope) that the whole thing has been removed (i.e., the margins are clear). That all sounds good.
And you are correct. Since you have not been diagonosed with malignant melanoma you don't need to see an oncologist.
-
- September 4, 2012 at 7:34 pm
Oh. I see. Well, it seems to me that you're on the right track (remember, I'm not a doctor). The pathologist said that if they had not removed all of the mole, they should go back and get the rest of it. So that's what your doctor is going to do. They will probably send this specimen to the pathologist, too, to make sure (under the microscope) that the whole thing has been removed (i.e., the margins are clear). That all sounds good.
And you are correct. Since you have not been diagonosed with malignant melanoma you don't need to see an oncologist.
-
- September 4, 2012 at 8:04 pm
Thank you, POW.
I understand you're not a doctor but you have given me more information than the nurse provided me. I struggle with a lot of anxiety issues and a mole that was supposed to be nothing has sent alarm bells off from this path report.
With anxiety, I tend to always think the worst. Although, there is no indication of melanoma, waiting for the final report will be very difficult. I must tell myself that a diagnosis cannot completey alter when looking at the same lesion. There is only a very small piece left of mole.
Once again, I appreciate you taking the time to help calm an anxiety ridden gal.
All my best to you!
-
- September 4, 2012 at 8:04 pm
Thank you, POW.
I understand you're not a doctor but you have given me more information than the nurse provided me. I struggle with a lot of anxiety issues and a mole that was supposed to be nothing has sent alarm bells off from this path report.
With anxiety, I tend to always think the worst. Although, there is no indication of melanoma, waiting for the final report will be very difficult. I must tell myself that a diagnosis cannot completey alter when looking at the same lesion. There is only a very small piece left of mole.
Once again, I appreciate you taking the time to help calm an anxiety ridden gal.
All my best to you!
-
- September 4, 2012 at 8:32 pm
My husband is an anxiety freak, too, and especially phobic about cancer. A wouldn't you know, a funny-looking freckle that suddenly turned black. It was on his forearm and he noticed the change at once, went immediately to the dermatologist and had it removed. It was a very, very small melanoma in situ.
That was 15 years ago, and he is fine now. But from that day to this, I scan every inch of his skin every month and he goes to the dermatologist for a scan every 6 months. The has learned to trust this "team" and that eases his anxiety.
My brother, on the other hand, kept refusing to have a funny-looking "freckle" on his leg removed for 2 years. "Oh, that's always been there." he said. Well, now he's got Stage IV melanoma with brain mets.
I think the lesson is: malignant melanoma is very rare. Basal cell and squamous cell carcinomas are much more common, but they are much less aggressive and easily treatable. Respect your own level of concern– don't pooh-pooh things like my brother did. Know the warning signs of malignant melanoma (what they call "ABCD"). Look at lots of pictures of different melanomas on the Internet. Then teach someone close to you what to look for. Scan yourself once a month. Have a friend or your spouse scan you once every couple of months. And visit a good dermatologist (with melanoma experience, not acne experience) twice a year. Then knowing that you have taken all reasonable precautions, forget about it!
-
- September 4, 2012 at 8:32 pm
My husband is an anxiety freak, too, and especially phobic about cancer. A wouldn't you know, a funny-looking freckle that suddenly turned black. It was on his forearm and he noticed the change at once, went immediately to the dermatologist and had it removed. It was a very, very small melanoma in situ.
That was 15 years ago, and he is fine now. But from that day to this, I scan every inch of his skin every month and he goes to the dermatologist for a scan every 6 months. The has learned to trust this "team" and that eases his anxiety.
My brother, on the other hand, kept refusing to have a funny-looking "freckle" on his leg removed for 2 years. "Oh, that's always been there." he said. Well, now he's got Stage IV melanoma with brain mets.
I think the lesson is: malignant melanoma is very rare. Basal cell and squamous cell carcinomas are much more common, but they are much less aggressive and easily treatable. Respect your own level of concern– don't pooh-pooh things like my brother did. Know the warning signs of malignant melanoma (what they call "ABCD"). Look at lots of pictures of different melanomas on the Internet. Then teach someone close to you what to look for. Scan yourself once a month. Have a friend or your spouse scan you once every couple of months. And visit a good dermatologist (with melanoma experience, not acne experience) twice a year. Then knowing that you have taken all reasonable precautions, forget about it!
-
- September 4, 2012 at 8:32 pm
My husband is an anxiety freak, too, and especially phobic about cancer. A wouldn't you know, a funny-looking freckle that suddenly turned black. It was on his forearm and he noticed the change at once, went immediately to the dermatologist and had it removed. It was a very, very small melanoma in situ.
That was 15 years ago, and he is fine now. But from that day to this, I scan every inch of his skin every month and he goes to the dermatologist for a scan every 6 months. The has learned to trust this "team" and that eases his anxiety.
My brother, on the other hand, kept refusing to have a funny-looking "freckle" on his leg removed for 2 years. "Oh, that's always been there." he said. Well, now he's got Stage IV melanoma with brain mets.
I think the lesson is: malignant melanoma is very rare. Basal cell and squamous cell carcinomas are much more common, but they are much less aggressive and easily treatable. Respect your own level of concern– don't pooh-pooh things like my brother did. Know the warning signs of malignant melanoma (what they call "ABCD"). Look at lots of pictures of different melanomas on the Internet. Then teach someone close to you what to look for. Scan yourself once a month. Have a friend or your spouse scan you once every couple of months. And visit a good dermatologist (with melanoma experience, not acne experience) twice a year. Then knowing that you have taken all reasonable precautions, forget about it!
-
- September 4, 2012 at 8:04 pm
Thank you, POW.
I understand you're not a doctor but you have given me more information than the nurse provided me. I struggle with a lot of anxiety issues and a mole that was supposed to be nothing has sent alarm bells off from this path report.
With anxiety, I tend to always think the worst. Although, there is no indication of melanoma, waiting for the final report will be very difficult. I must tell myself that a diagnosis cannot completey alter when looking at the same lesion. There is only a very small piece left of mole.
Once again, I appreciate you taking the time to help calm an anxiety ridden gal.
All my best to you!
-
- September 4, 2012 at 7:05 pm
POW-The mole is going to be excised again to make sure everything is taken. So I was wondering about that next report. What is it looking for?
Also-I am not seeing an oncologist. I have not been diagnosed with anything. I Just had a mole taken off a few weeks ago from my regular derm.
-
- September 4, 2012 at 7:05 pm
POW-The mole is going to be excised again to make sure everything is taken. So I was wondering about that next report. What is it looking for?
Also-I am not seeing an oncologist. I have not been diagnosed with anything. I Just had a mole taken off a few weeks ago from my regular derm.
-
- September 4, 2012 at 6:44 pm
I am impressed by your biopsy report and its use of antigin staining results…so much more advanced then my initial biopsy was. Perhaps this www could give you some understanding http://www.ventana.com/product/121?type=115
Just wait for the results…its very early regardless of the diagnosis.Wondering why you say its's rare? Did your oncologist give you a name for it?
-
- You must be logged in to reply to this topic.