Has anyone tried the new clinical trial OX40

Becky,

This is a copy and paste that a friend emailed me a couple years ago.  Looks like OX40 was tested on patients as early as 2010.  The trial you are talking about maybe the first trial for a different company making OX40 or trying it a different way.  I'll use the contact option on the board to email you Dr. Curti's email address.  I've never spoken or written him but a friend emailed him for me and then forwarded his response to me so that's how I have his email address.  My friend spoke very highly of him so he might be willing to share some insights with you.

If you don't get my email let me know.

Brian

OX40 Update

OX40 is a protein found on immune cells in our bodies that can boost our immune systems to attack cancerous tumors.  After 10+ years’ work at Providence, Drs. Brendan Curti (right) and Andy Weinberg (far right) completed the world’s first patient trial with OX40 in 2010. We saw an unusually strong response rate among patients and the scientific community took notice.  Results from continued research, supported by philanthropy and scientific grants, and the patient trial garnered the attention of major pharma-ceutical companies looking to invest in promising research.  In 2011, business relationships were established with AgonOX and MedImmune, a subsidiary of Astra-Zeneca, for continued development of the OX40 therapies for patients with many types of cancer.  Today, MedImmune is investing in further development of OX40, and along with Providence and AgonOX, is expanding clinical trials for patients with melanoma, breast cancer, and prostate cancer.  The OX40 project continues with the hope that in the next decade a new therapy will be available for patients with cancer. Providence researchers and physicians remain actively involved, as are Providence patients. 

Becky,

This is a copy and paste that a friend emailed me a couple years ago.  Looks like OX40 was tested on patients as early as 2010.  The trial you are talking about maybe the first trial for a different company making OX40 or trying it a different way.  I'll use the contact option on the board to email you Dr. Curti's email address.  I've never spoken or written him but a friend emailed him for me and then forwarded his response to me so that's how I have his email address.  My friend spoke very highly of him so he might be willing to share some insights with you.

If you don't get my email let me know.

Brian

OX40 Update

OX40 is a protein found on immune cells in our bodies that can boost our immune systems to attack cancerous tumors.  After 10+ years’ work at Providence, Drs. Brendan Curti (right) and Andy Weinberg (far right) completed the world’s first patient trial with OX40 in 2010. We saw an unusually strong response rate among patients and the scientific community took notice.  Results from continued research, supported by philanthropy and scientific grants, and the patient trial garnered the attention of major pharma-ceutical companies looking to invest in promising research.  In 2011, business relationships were established with AgonOX and MedImmune, a subsidiary of Astra-Zeneca, for continued development of the OX40 therapies for patients with many types of cancer.  Today, MedImmune is investing in further development of OX40, and along with Providence and AgonOX, is expanding clinical trials for patients with melanoma, breast cancer, and prostate cancer.  The OX40 project continues with the hope that in the next decade a new therapy will be available for patients with cancer. Providence researchers and physicians remain actively involved, as are Providence patients. 

Becky,

This is a copy and paste that a friend emailed me a couple years ago.  Looks like OX40 was tested on patients as early as 2010.  The trial you are talking about maybe the first trial for a different company making OX40 or trying it a different way.  I'll use the contact option on the board to email you Dr. Curti's email address.  I've never spoken or written him but a friend emailed him for me and then forwarded his response to me so that's how I have his email address.  My friend spoke very highly of him so he might be willing to share some insights with you.

If you don't get my email let me know.

Brian

OX40 Update

OX40 is a protein found on immune cells in our bodies that can boost our immune systems to attack cancerous tumors.  After 10+ years’ work at Providence, Drs. Brendan Curti (right) and Andy Weinberg (far right) completed the world’s first patient trial with OX40 in 2010. We saw an unusually strong response rate among patients and the scientific community took notice.  Results from continued research, supported by philanthropy and scientific grants, and the patient trial garnered the attention of major pharma-ceutical companies looking to invest in promising research.  In 2011, business relationships were established with AgonOX and MedImmune, a subsidiary of Astra-Zeneca, for continued development of the OX40 therapies for patients with many types of cancer.  Today, MedImmune is investing in further development of OX40, and along with Providence and AgonOX, is expanding clinical trials for patients with melanoma, breast cancer, and prostate cancer.  The OX40 project continues with the hope that in the next decade a new therapy will be available for patients with cancer. Providence researchers and physicians remain actively involved, as are Providence patients. 

Becky,

Doesn't look like your profile has the option to contact.  You should be able to contact me if you want and I'll reply with his email address.  Probably silly but I'm a little hesitant to post his email address on an open forum.

Becky,

Doesn't look like your profile has the option to contact.  You should be able to contact me if you want and I'll reply with his email address.  Probably silly but I'm a little hesitant to post his email address on an open forum.

Becky,

Doesn't look like your profile has the option to contact.  You should be able to contact me if you want and I'll reply with his email address.  Probably silly but I'm a little hesitant to post his email address on an open forum.

Hi there, 

i just saw that you were thinking of trying the OX40 trial. I am wondering if you did this? My 18yr old son has been on keytruda for 9 months and has had no shrinkage in 6 months and new tumors. He has mets in liver, lungs, spine, bones(sternum is very bad), stomach, chest, neck…still not brain as of 3 mo ago. I feel he can't last much longer with this tumor load. As of now he has almost no pain, is very active, and other than fatigue is fine on keytruda. We need an option. He has only seen one dr in our local cancer center, but it's a good place w specialists etc. He was diagnosed Sept 2014. This is a hellish ride, you know. Looking for a new option…hoping you have found one that is working for you! 

Prayers,

Kerri

Hi there, 

i just saw that you were thinking of trying the OX40 trial. I am wondering if you did this? My 18yr old son has been on keytruda for 9 months and has had no shrinkage in 6 months and new tumors. He has mets in liver, lungs, spine, bones(sternum is very bad), stomach, chest, neck…still not brain as of 3 mo ago. I feel he can't last much longer with this tumor load. As of now he has almost no pain, is very active, and other than fatigue is fine on keytruda. We need an option. He has only seen one dr in our local cancer center, but it's a good place w specialists etc. He was diagnosed Sept 2014. This is a hellish ride, you know. Looking for a new option…hoping you have found one that is working for you! 

Prayers,

Kerri

Hi there, 

i just saw that you were thinking of trying the OX40 trial. I am wondering if you did this? My 18yr old son has been on keytruda for 9 months and has had no shrinkage in 6 months and new tumors. He has mets in liver, lungs, spine, bones(sternum is very bad), stomach, chest, neck…still not brain as of 3 mo ago. I feel he can't last much longer with this tumor load. As of now he has almost no pain, is very active, and other than fatigue is fine on keytruda. We need an option. He has only seen one dr in our local cancer center, but it's a good place w specialists etc. He was diagnosed Sept 2014. This is a hellish ride, you know. Looking for a new option…hoping you have found one that is working for you! 

Prayers,

Kerri

More links —

Medimmune trial announctement: http://itsoftware.pharmaceutical-business-review.com/news/medimmunes-phase-i-ox40-agonist-trial-uses-agonoxs-ox40-platform-211014-4411475

A long discussion of OX-40 here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622727/

A short video: https://www.azimmuno-oncology.com/ox40-agonist?source=ALLH3913

More links —

Medimmune trial announctement: http://itsoftware.pharmaceutical-business-review.com/news/medimmunes-phase-i-ox40-agonist-trial-uses-agonoxs-ox40-platform-211014-4411475

A long discussion of OX-40 here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622727/

A short video: https://www.azimmuno-oncology.com/ox40-agonist?source=ALLH3913

More links —

Medimmune trial announctement: http://itsoftware.pharmaceutical-business-review.com/news/medimmunes-phase-i-ox40-agonist-trial-uses-agonoxs-ox40-platform-211014-4411475

A long discussion of OX-40 here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622727/

A short video: https://www.azimmuno-oncology.com/ox40-agonist?source=ALLH3913

Kyle, You are definitely the Ultimate Google Jedi Master! 

Great info.

Kyle, You are definitely the Ultimate Google Jedi Master! 

Great info.

Kyle, You are definitely the Ultimate Google Jedi Master! 

Great info.

Thanks Becky! I will try to do that!

– Kyle

Thanks Becky! I will try to do that!

– Kyle

Thanks Becky! I will try to do that!

– Kyle

Becky, I was also thinking, you don't have to stick with only only the clinical trials offered at your facility (Angeles clinic?). For example the clinical trial I'm in is a long way from home. I'm in it because there was nothing promising near me two years ago. I figured out it wasn't the job of my oncologist to try to find me a trial somewhere else. I spent a lot of time looking at what might be available at clinicaltrials.gov, and then a lot of phone calls to several dozen facilities. I didn't understand until several years in that I could do this (look for trials anywhere, and not just stick with my home oncologist/facility).

Have you ever sought a second opinion? I haven't for awhile, but I did early on in my treatment, once, when there was a big fork in the road for me. Did your doc give you his rationale for his recommendation of the OX40 drug, especially specifically related to bone metastases?

Another part of your oncologist's rationale might also be what trials your previous treatment allows you to qualify for. Like some trials might not allow prior therapies like PD1. I also learned about those kinds of 'exclusion criteria' during my search. Getting help on that front is an advantage of having your oncologist facilitating you getting into a trial.

Becky, I was also thinking, you don't have to stick with only only the clinical trials offered at your facility (Angeles clinic?). For example the clinical trial I'm in is a long way from home. I'm in it because there was nothing promising near me two years ago. I figured out it wasn't the job of my oncologist to try to find me a trial somewhere else. I spent a lot of time looking at what might be available at clinicaltrials.gov, and then a lot of phone calls to several dozen facilities. I didn't understand until several years in that I could do this (look for trials anywhere, and not just stick with my home oncologist/facility).

Have you ever sought a second opinion? I haven't for awhile, but I did early on in my treatment, once, when there was a big fork in the road for me. Did your doc give you his rationale for his recommendation of the OX40 drug, especially specifically related to bone metastases?

Another part of your oncologist's rationale might also be what trials your previous treatment allows you to qualify for. Like some trials might not allow prior therapies like PD1. I also learned about those kinds of 'exclusion criteria' during my search. Getting help on that front is an advantage of having your oncologist facilitating you getting into a trial.

Becky, I was also thinking, you don't have to stick with only only the clinical trials offered at your facility (Angeles clinic?). For example the clinical trial I'm in is a long way from home. I'm in it because there was nothing promising near me two years ago. I figured out it wasn't the job of my oncologist to try to find me a trial somewhere else. I spent a lot of time looking at what might be available at clinicaltrials.gov, and then a lot of phone calls to several dozen facilities. I didn't understand until several years in that I could do this (look for trials anywhere, and not just stick with my home oncologist/facility).

Have you ever sought a second opinion? I haven't for awhile, but I did early on in my treatment, once, when there was a big fork in the road for me. Did your doc give you his rationale for his recommendation of the OX40 drug, especially specifically related to bone metastases?

Another part of your oncologist's rationale might also be what trials your previous treatment allows you to qualify for. Like some trials might not allow prior therapies like PD1. I also learned about those kinds of 'exclusion criteria' during my search. Getting help on that front is an advantage of having your oncologist facilitating you getting into a trial.

Ed,

I don't know if this will help but I started using Chrome instead of explorer when I want to post links or paste something.  Seems to work better for me.

Brian

Ed,

I don't know if this will help but I started using Chrome instead of explorer when I want to post links or paste something.  Seems to work better for me.

Brian

Ed,

I don't know if this will help but I started using Chrome instead of explorer when I want to post links or paste something.  Seems to work better for me.

Brian