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GSK Braf/MEK combo trial

Forums General Melanoma Community GSK Braf/MEK combo trial

  • Post
    killmel
    Participant

    Hi All

    I am interested in any feedback regarding the GSK BRAF/MEK combo trial. Anyone in this trial??? What are the side effects & how are you managing them?? Thanks so much for your feedback.

    http://clinicaltrials.gov/ct2/show/NCT01072175

     

    Wishing everyone a lifetime of NED

    Jan

    Hi All

    I am interested in any feedback regarding the GSK BRAF/MEK combo trial. Anyone in this trial??? What are the side effects & how are you managing them?? Thanks so much for your feedback.

    http://clinicaltrials.gov/ct2/show/NCT01072175

     

    Wishing everyone a lifetime of NED

    Jan

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  • Replies
      kthekhal
      Participant

      Mr/Ms Anonymous,

         Greetings !! MPIP is like a family of Melanoma patients (yes like  brothers & sisters )  who share their pain & gain with each other… I personally request you to disclose your identity  –  so that other  sisters & brothers in this family can share their experiences with you …. Please don't  assume any offence in my post   –  I am a stage 3B survivor myself.

      With deep gratitude,

      Your Brother in pain.

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      kthekhal
      Participant

      Mr/Ms Anonymous,

         Greetings !! MPIP is like a family of Melanoma patients (yes like  brothers & sisters )  who share their pain & gain with each other… I personally request you to disclose your identity  –  so that other  sisters & brothers in this family can share their experiences with you …. Please don't  assume any offence in my post   –  I am a stage 3B survivor myself.

      With deep gratitude,

      Your Brother in pain.

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      kthekhal
      Participant

      Mr/Ms Anonymous,

         Greetings !! MPIP is like a family of Melanoma patients (yes like  brothers & sisters )  who share their pain & gain with each other… I personally request you to disclose your identity  –  so that other  sisters & brothers in this family can share their experiences with you …. Please don't  assume any offence in my post   –  I am a stage 3B survivor myself.

      With deep gratitude,

      Your Brother in pain.

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        bcl
        Participant

        this would be so much more welcoming had you not posted anon yourself..

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        killmel
        Participant

        I am so sorry I offended everyone. But if you read my original post I did sign my name "JAN". I hit the wrong button "anonymous" when I posted my question.  I did not realize how serious that mistake was to  offend you. I am a "newbie" and trying to learn how touse the website.  I will think twice about posting again. Jan

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        killmel
        Participant

        I am so sorry I offended everyone. But if you read my original post I did sign my name "JAN". I hit the wrong button "anonymous" when I posted my question.  I did not realize how serious that mistake was to  offend you. I am a "newbie" and trying to learn how touse the website.  I will think twice about posting again. Jan

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        lhaley
        Participant

        Jan,

        Please don't let one individual make you think twice about posting for information!!

        I really can't help you with your question. Yesterday I found out I was B-raf positive. My oncologist is very excited about the combo trials. We didn't talk side effects.  My tentative plan is to try IL2 first, then if that doesn't work ipi. I personally don't like the idea of something that you will need to stay on. Of course if the other two options don't work I'll be right there!!

        Linda

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        lhaley
        Participant

        Jan,

        Please don't let one individual make you think twice about posting for information!!

        I really can't help you with your question. Yesterday I found out I was B-raf positive. My oncologist is very excited about the combo trials. We didn't talk side effects.  My tentative plan is to try IL2 first, then if that doesn't work ipi. I personally don't like the idea of something that you will need to stay on. Of course if the other two options don't work I'll be right there!!

        Linda

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        jim Breitfeller
        Participant

        Linda,

        You may want to reverse the sequence of your Therapies. Try Ipi first followed by IL-2. If you do IL-2 first, you may end up growing the TRegs which my supress your immune system and the response. If you have questions, you can contact me at [email protected]

        I wish you well.

        Happy Holidays

         

        Jimmy B

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        jim Breitfeller
        Participant

        Linda,

        You may want to reverse the sequence of your Therapies. Try Ipi first followed by IL-2. If you do IL-2 first, you may end up growing the TRegs which my supress your immune system and the response. If you have questions, you can contact me at [email protected]

        I wish you well.

        Happy Holidays

         

        Jimmy B

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        bcl
        Participant

        this would be so much more welcoming had you not posted anon yourself..

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      kthekhal
      Participant

      Mr/Ms Anonymous,

         Greetings !! MPIP is like a family of Melanoma patients (yes like  brothers & sisters )  who share their pain & gain with each other… I personally request you to disclose your identity  –  so that other  sisters & brothers in this family can share their experiences with you …. Please don't  assume any offence in my post   –  I am a stage 3B survivor myself.

      With deep gratitude,

      Your Brother in pain.

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      Lauren mom to Jenna
      Participant

      The side effects of the BRAF/MEK combo are very mild.  Perhaps some mild diarrhea, easily controlled with imodium.  Jenna did not even experience the bad rash with the combo that she did on the MEK alone.  Biggest side effects…hope and elation, as you feel (if you have palpable tumors) your tumors shrink. 

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      Lauren mom to Jenna
      Participant

      The side effects of the BRAF/MEK combo are very mild.  Perhaps some mild diarrhea, easily controlled with imodium.  Jenna did not even experience the bad rash with the combo that she did on the MEK alone.  Biggest side effects…hope and elation, as you feel (if you have palpable tumors) your tumors shrink. 

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      billb50256
      Participant

      Stage IV, with Unknown Primary, tumors in lymph nodes, and shoulder. Neck dissection, Interferon…..currently on the BRAF-MEK trial at MDAnderson. First two month cycle showed all tumors shrunk, anywhere from 10 to 50%. I have had virtually no side effects. Fatigue (could also be blamed on the 3 pain meds), a little bit of neck rash, occasional ringing in the ears. So far, so good. My second cycle is up in late March and I'll get another set of scans. Bottom line, the treatment appears to be helping and the side effects not a problem. When you compare the side effects with other treatments, it's a miracle.

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      billb50256
      Participant

      Stage IV, with Unknown Primary, tumors in lymph nodes, and shoulder. Neck dissection, Interferon…..currently on the BRAF-MEK trial at MDAnderson. First two month cycle showed all tumors shrunk, anywhere from 10 to 50%. I have had virtually no side effects. Fatigue (could also be blamed on the 3 pain meds), a little bit of neck rash, occasional ringing in the ears. So far, so good. My second cycle is up in late March and I'll get another set of scans. Bottom line, the treatment appears to be helping and the side effects not a problem. When you compare the side effects with other treatments, it's a miracle.

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