??? for Bubbles

Hi Jewel,

The short answer is…YES! Patients given ipi can have durable responses at 3 or 10mg/kg doses. We do have more extended data collected on the 10mg/kg option because that was how it was given initially so the time line we can follow is longer. You have to look back a bit to find hard data on ipi because with the advent of anti-PD1 and immunotherapy combo's, ipi is 'old news'. But here, the researchers note specifically that dosing was not a significant varible when it comes to durable responses:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2013/11/melanoma-patientsalive-and-kicking-10.html

Here is a more recent post with a great deal of data on patients given ipi:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2015/03/ipi-for-melanomathe-data-keeps-pouring.html

The sad part about ipi is the low response rate (10-15% vs 40% for anti-PD1, not to mention various combo's) and increased rate of side effects generally. However, durable responses are certainly attained at both the 3 and 10 mg dosing regimen.

Thanks for your kind words. Good luck in August! Celeste

Hi Jewel,

The short answer is…YES! Patients given ipi can have durable responses at 3 or 10mg/kg doses. We do have more extended data collected on the 10mg/kg option because that was how it was given initially so the time line we can follow is longer. You have to look back a bit to find hard data on ipi because with the advent of anti-PD1 and immunotherapy combo's, ipi is 'old news'. But here, the researchers note specifically that dosing was not a significant varible when it comes to durable responses:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2013/11/melanoma-patientsalive-and-kicking-10.html

Here is a more recent post with a great deal of data on patients given ipi:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2015/03/ipi-for-melanomathe-data-keeps-pouring.html

The sad part about ipi is the low response rate (10-15% vs 40% for anti-PD1, not to mention various combo's) and increased rate of side effects generally. However, durable responses are certainly attained at both the 3 and 10 mg dosing regimen.

Thanks for your kind words. Good luck in August! Celeste

Hi Jewel,

The short answer is…YES! Patients given ipi can have durable responses at 3 or 10mg/kg doses. We do have more extended data collected on the 10mg/kg option because that was how it was given initially so the time line we can follow is longer. You have to look back a bit to find hard data on ipi because with the advent of anti-PD1 and immunotherapy combo's, ipi is 'old news'. But here, the researchers note specifically that dosing was not a significant varible when it comes to durable responses:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2013/11/melanoma-patientsalive-and-kicking-10.html

Here is a more recent post with a great deal of data on patients given ipi:  http://chaoticallypreciselifeloveandmelanoma.blogspot.ca/2015/03/ipi-for-melanomathe-data-keeps-pouring.html

The sad part about ipi is the low response rate (10-15% vs 40% for anti-PD1, not to mention various combo's) and increased rate of side effects generally. However, durable responses are certainly attained at both the 3 and 10 mg dosing regimen.

Thanks for your kind words. Good luck in August! Celeste

Hi Jewel, just to add to what you have been given is an article from ASCO with the same data that you will find on Celeste blog. Also if you look up Dr. James Allison who now works at M.D. Anderson and listen to any of his presentation about Ipi you will here him talk about patients who reach 3 year on survival graphs tend to stay responding. Best wishes!!!!Ed http://jco.ascopubs.org/content/early/2015/02/03/JCO.2014.56.2736.short

Hi Jewel, just to add to what you have been given is an article from ASCO with the same data that you will find on Celeste blog. Also if you look up Dr. James Allison who now works at M.D. Anderson and listen to any of his presentation about Ipi you will here him talk about patients who reach 3 year on survival graphs tend to stay responding. Best wishes!!!!Ed http://jco.ascopubs.org/content/early/2015/02/03/JCO.2014.56.2736.short

Hi Jewel, just to add to what you have been given is an article from ASCO with the same data that you will find on Celeste blog. Also if you look up Dr. James Allison who now works at M.D. Anderson and listen to any of his presentation about Ipi you will here him talk about patients who reach 3 year on survival graphs tend to stay responding. Best wishes!!!!Ed http://jco.ascopubs.org/content/early/2015/02/03/JCO.2014.56.2736.short