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Eric’s Scans – Some Good Some Bad?

Forums General Melanoma Community Eric’s Scans – Some Good Some Bad?

  • Post
    EricNJill
    Participant

    Eric has been on the GSK BRAF/MEK Combo Trial.  The changes in his leg have been outstanding!  His tumors are shrinking rapidly.  One external tumor on his leg went from being 4 1/4 inches to less than 2 inches and his leg is actually normal size for the internal tumors shrinking.

    Eric has been on the GSK BRAF/MEK Combo Trial.  The changes in his leg have been outstanding!  His tumors are shrinking rapidly.  One external tumor on his leg went from being 4 1/4 inches to less than 2 inches and his leg is actually normal size for the internal tumors shrinking.

    What is confusing for me is that he has new enlarged tumors around his heart and new non-calcified nodules in his lungs.  Why would the treatment work in his leg and not the heart and lungs?  His Oncologist said that if he hadn't obviously had response in his leg they probably would have stopped the treatment.

    Thanks for any help.  JillNEric in OH

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      jim Breitfeller
      Participant

      Jill n Eric,

      It is possible that differnt locations may have different mutations. Where was he tested for BRAF?  Can they Biopsy the heart and lung nodules? It may help the path foward.

      Best regards,

      Jimmy B

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        EricNJill
        Participant

        Hi Jim,

        I didn't realize that you could have different mutations in different areas…wow.  He was tested on the leg, which would explain why the treatment is working in his leg.  They have not biopsied the lungs and heart.  They just recently showed up on the January, 2011 scan and then again on this most recent scan March 18th.

        Jill

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        EricNJill
        Participant

        Hi Jim,

        I didn't realize that you could have different mutations in different areas…wow.  He was tested on the leg, which would explain why the treatment is working in his leg.  They have not biopsied the lungs and heart.  They just recently showed up on the January, 2011 scan and then again on this most recent scan March 18th.

        Jill

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      jim Breitfeller
      Participant

      Jill n Eric,

      It is possible that differnt locations may have different mutations. Where was he tested for BRAF?  Can they Biopsy the heart and lung nodules? It may help the path foward.

      Best regards,

      Jimmy B

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      Lori C
      Participant

      Jill, Will's subcutaneous tumors responded very quickly to biochemotherapy and the taxol/carboplatin regimen, while his liver and spleen tumors did not.  I am not sure if it is just a matter of the internal tumors being more difficult in terms of a response or slower or what the issue is. 

      I can't offer much in the way of explanation – only can tell you that this was our experience on a different treatment regimen as well. 

      Are the tumors by his heart operable?

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      Lori C
      Participant

      Jill, Will's subcutaneous tumors responded very quickly to biochemotherapy and the taxol/carboplatin regimen, while his liver and spleen tumors did not.  I am not sure if it is just a matter of the internal tumors being more difficult in terms of a response or slower or what the issue is. 

      I can't offer much in the way of explanation – only can tell you that this was our experience on a different treatment regimen as well. 

      Are the tumors by his heart operable?

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      premedy
      Participant

      I can't be of any help but just wanted to say I read your previous posts and I'm pulling for you guys.

      pat

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      premedy
      Participant

      I can't be of any help but just wanted to say I read your previous posts and I'm pulling for you guys.

      pat

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        killmel
        Participant

        Hi Jill,

         

        How is Eric's infection? Have the antibiotic helped…are they working??

        Hang tough, we are all ulling for you!.

        Wendy

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        killmel
        Participant

        Hi Jill,

         

        How is Eric's infection? Have the antibiotic helped…are they working??

        Hang tough, we are all ulling for you!.

        Wendy

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