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Eric got into Braf & MEK trial at Nashville!

Forums General Melanoma Community Eric got into Braf & MEK trial at Nashville!

  • Post
    EricNJill
    Participant

    I can't tell you have happy I am that Eric got into the GSK BRAF Inhibitor and MEK combination trial!  They said he got the last opening.  He won't begin for a couple of weeks but it's just a huge relief knowing he got in.  He has a brain MRI on Thursday to make sure that his brain is still clear after the craniotomy.  I asked them about the hospice palliative care he is receiving and they said there was no problems.

    I can't tell you have happy I am that Eric got into the GSK BRAF Inhibitor and MEK combination trial!  They said he got the last opening.  He won't begin for a couple of weeks but it's just a huge relief knowing he got in.  He has a brain MRI on Thursday to make sure that his brain is still clear after the craniotomy.  I asked them about the hospice palliative care he is receiving and they said there was no problems.

    He took his last pill of Temodar (2nd round) on Sunday.  His leg looks horrible.  He has new tumors and the existing tumors are bigger so that makes it even more joyous that he got in.  I hate to think about every day that goes by with Melanoma raging on!

    I know there are others here on this trial, can you tell me about your experiences.

    Thanks, JillNEric In OH

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      Sherron
      Participant

      Jill, this is wonderful news for you and Eric.  I am very happy for you…I will continue to think and pray for you daily.

      Wishing and hoping for the best for both of you.

      Take Care,

      Sherron, wife to Jim FOREVER

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      Sherron
      Participant

      Jill, this is wonderful news for you and Eric.  I am very happy for you…I will continue to think and pray for you daily.

      Wishing and hoping for the best for both of you.

      Take Care,

      Sherron, wife to Jim FOREVER

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      killmel
      Participant

      SOOO HAppy for you both. What a relief!

      I am very interested in the MEK/Braf combo trial too.

      Any info the doc /study nurse gave you about this trial (like what are the side effects, how effective has these comb drugs been working on their patients thus far on this trial, etc).

      Thank you for any info you might have.

      I pray for you both & keep the faith, miracles do happen.

      Douglas

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      killmel
      Participant

      SOOO HAppy for you both. What a relief!

      I am very interested in the MEK/Braf combo trial too.

      Any info the doc /study nurse gave you about this trial (like what are the side effects, how effective has these comb drugs been working on their patients thus far on this trial, etc).

      Thank you for any info you might have.

      I pray for you both & keep the faith, miracles do happen.

      Douglas

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      killmel
      Participant

      SOOO HAppy for you both. What a relief!

      I am very interested in the MEK/Braf combo trial too.

      Any info the doc /study nurse gave you about this trial (like what are the side effects, how effective has these comb drugs been working on their patients thus far on this trial, etc).

      Thank you for any info you might have.

      I pray for you both & keep the faith, miracles do happen.

      Douglas

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      killmel
      Participant

      SOOO HAppy for you both. What a relief!

      I am very interested in the MEK/Braf combo trial too.

      Any info the doc /study nurse gave you about this trial (like what are the side effects, how effective has these comb drugs been working on their patients thus far on this trial, etc).

      Thank you for any info you might have.

      I pray for you both & keep the faith, miracles do happen.

      Douglas

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        EricNJill
        Participant

        Douglas,

        They really didn't get into the effectiveness of the two drugs in combination, but I've read good things about it.  She did say that the most common side effects are diarrhea and a bad rash.  They also said that they are seeing squamous cell cancers pop up on patients that are on the MEK drug as well as fluid build up behind the retina that causes blurred vision.  So before he starts the trial he has to be evaluated by a Dermatologist and an Ophthalmologist and checked routinely. 

        Of course the clinical trial material name many other side-effects but I guess these are the ones they are most concerned about. 

        In comparison to IL-2 these side effects are nothing! 

        JillNEric IN OH

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        EricNJill
        Participant

        Douglas,

        They really didn't get into the effectiveness of the two drugs in combination, but I've read good things about it.  She did say that the most common side effects are diarrhea and a bad rash.  They also said that they are seeing squamous cell cancers pop up on patients that are on the MEK drug as well as fluid build up behind the retina that causes blurred vision.  So before he starts the trial he has to be evaluated by a Dermatologist and an Ophthalmologist and checked routinely. 

        Of course the clinical trial material name many other side-effects but I guess these are the ones they are most concerned about. 

        In comparison to IL-2 these side effects are nothing! 

        JillNEric IN OH

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      Vermont_Donna
      Participant

      GREAT news!!!! I am so happy for you both! What courage you both have and hope……..never give up! I look at the pictures of Erics leg and it puts my leg tumors in such perspective. Hang in there, the waiting for things to start is hard.

      Hugs,

      Vermont_Donna

      stage 3a

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      Vermont_Donna
      Participant

      GREAT news!!!! I am so happy for you both! What courage you both have and hope……..never give up! I look at the pictures of Erics leg and it puts my leg tumors in such perspective. Hang in there, the waiting for things to start is hard.

      Hugs,

      Vermont_Donna

      stage 3a

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      Linda J
      Participant
      Hurray – that’s awesome! I start the Braf/Mek combo trial on the 19th. I’ve got a busy week of scans, blood work, heart tests, eye exams etc.
      It makes me feel good knowing that these two drugs on their own have helped people. I don’t feel as much as a guinea pig that way!
      My nurse has said that of the different types of cancer patients who are on this trial, the melanoma patients seem to be having the best results – hurray!!!!
      All the best!
      Linda J

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      Linda J
      Participant
      Hurray – that’s awesome! I start the Braf/Mek combo trial on the 19th. I’ve got a busy week of scans, blood work, heart tests, eye exams etc.
      It makes me feel good knowing that these two drugs on their own have helped people. I don’t feel as much as a guinea pig that way!
      My nurse has said that of the different types of cancer patients who are on this trial, the melanoma patients seem to be having the best results – hurray!!!!
      All the best!
      Linda J

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        killmel
        Participant

        Hi linda,

        What side effects did the study nurse tell you patients have been getting on this MEK/BRAk combo trial?? Did you get any yet and how are you mananging the,M

        Thanks

        Jan

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        killmel
        Participant

        Hi linda,

        What side effects did the study nurse tell you patients have been getting on this MEK/BRAk combo trial?? Did you get any yet and how are you mananging the,M

        Thanks

        Jan

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        Linda J
        Participant
        Hi,
        She said the most common thing she is seeing is a rash that seems to present on the face, she said it was similar to acne (great!). She said it seems to come and go in waves.
        Another person on the board, emilypen, her husband had been on this trial for several months so she would have more Info about side effects.
        Linda J

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        Linda J
        Participant
        Hi,
        She said the most common thing she is seeing is a rash that seems to present on the face, she said it was similar to acne (great!). She said it seems to come and go in waves.
        Another person on the board, emilypen, her husband had been on this trial for several months so she would have more Info about side effects.
        Linda J

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      JuleFL
      Participant
      I am so happy to hear this, Jill. Best wishes for Eric’s success in this trial. Keep us posted.
      Jule

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      JuleFL
      Participant
      I am so happy to hear this, Jill. Best wishes for Eric’s success in this trial. Keep us posted.
      Jule

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      jag
      Participant

      That is great news that Eric got into the trial Jill, I will say a prayer that his MRI will be negative and he gets the medication.

      Best
      John 

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      jag
      Participant

      That is great news that Eric got into the trial Jill, I will say a prayer that his MRI will be negative and he gets the medication.

      Best
      John 

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      LynnLuc
      Participant

      Awesome news!!! Blessings for the trial!!

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      LynnLuc
      Participant

      Awesome news!!! Blessings for the trial!!

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      Lori C
      Participant

      That is excellent news – and may this be exactly what Eric needs.  I am especially glad that they are not negative towards the hospice option you had chosen; I think it is wonderful to get that kind of support when someone is unwell but you  shouldn't have to reject future viable treatments because of it. 

      Best to both of you!

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      Lori C
      Participant

      That is excellent news – and may this be exactly what Eric needs.  I am especially glad that they are not negative towards the hospice option you had chosen; I think it is wonderful to get that kind of support when someone is unwell but you  shouldn't have to reject future viable treatments because of it. 

      Best to both of you!

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      MaryD
      Participant

      That is such great news Jill – I'm so happy for you and Eric.   He is an amazing fighter and he is so lucky to have you for support.   This is the cutting edge trial to be in and I will be praying hard that it beats back this awful disease.

      Sending good thoughts for a clear MRI and wishing Eric good luck!

       

      Mary

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      MaryD
      Participant

      That is such great news Jill – I'm so happy for you and Eric.   He is an amazing fighter and he is so lucky to have you for support.   This is the cutting edge trial to be in and I will be praying hard that it beats back this awful disease.

      Sending good thoughts for a clear MRI and wishing Eric good luck!

       

      Mary

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      yensidw
      Participant

      Very good news!  I used to work for GSK and am happy that their drug is helping some people.  Ppraying that this will be the answer for Eric.

       

      Janis 

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      yensidw
      Participant

      Very good news!  I used to work for GSK and am happy that their drug is helping some people.  Ppraying that this will be the answer for Eric.

       

      Janis 

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      tennisgirl
      Participant

      Jill:  Since I have been reading your posts, I think about you and Eric often.  I too hope to get on this trial in February.    Please continue with the updates.  Keep on keeping on! 

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      tennisgirl
      Participant

      Jill:  Since I have been reading your posts, I think about you and Eric often.  I too hope to get on this trial in February.    Please continue with the updates.  Keep on keeping on! 

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      Wife of Carl
      Participant

      Jill,

      Great news that Eric got a slot on the trial!  My husband is on a MEK trial at SCRI in Nashville, with Dr. Infante.  He gets the same MEK drug that Eric will get.  So far, he is doing great.  He began to see results a few weeks after starting the drug.  He did get the rash about two weeks after starting but it is manageable….better than melanoma!!!  He gets diarrhea and he does get fatigued sometimes, but these things do not stop him from doing almost everything that he wants to.  I hope that this trial will be the same miracle for Eric as it has been for my husband.

      Pat

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      Wife of Carl
      Participant

      Jill,

      Great news that Eric got a slot on the trial!  My husband is on a MEK trial at SCRI in Nashville, with Dr. Infante.  He gets the same MEK drug that Eric will get.  So far, he is doing great.  He began to see results a few weeks after starting the drug.  He did get the rash about two weeks after starting but it is manageable….better than melanoma!!!  He gets diarrhea and he does get fatigued sometimes, but these things do not stop him from doing almost everything that he wants to.  I hope that this trial will be the same miracle for Eric as it has been for my husband.

      Pat

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      Rocklove
      Participant

      Such Great News for You and Jack. I have no experience wih the combo trial but do know Jack is so lucky. I tested BRAF Negative, so doubtful if the combo is a choice for me. I heard there have been a lot of positive results from the test.

      Praying for You Two and Family and so are so many others.

      Rocky (Stage IV Liver Mets)

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      Rocklove
      Participant

      Such Great News for You and Jack. I have no experience wih the combo trial but do know Jack is so lucky. I tested BRAF Negative, so doubtful if the combo is a choice for me. I heard there have been a lot of positive results from the test.

      Praying for You Two and Family and so are so many others.

      Rocky (Stage IV Liver Mets)

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