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Dr. Ribas Adoptive Cell Therapy with a new twist.
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Dr. Ribas Adoptive Cell Therapy with a new twist.

› Forums › General Melanoma Community › Dr. Ribas Adoptive Cell Therapy with a new twist.

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    • February 4, 2020 at 4:06 pm
    ed williams
    Participant
      When melanoma patients choose TIL’s they normally get IL-2 after chemo depletion to rev the immune system up so that when they get the TIL’s infusion, the IL-2 will help prime the immune system so the T-cell will get into the melanoma tumor cells. NKTR-214 has been in clinical trial (Pivot 02 trial) for a couple of years in combination with Pd-1 Nivolumab. They now called NKTR-214 “Bempegaldesleukin” which is old school IL-2 with a twist of being pegylated which reduces the toxicity compared with old school IL-2. Now, while we are still waiting for data on NKTR-214 + nivo to see if early trial results hold up, it does make sense to use it in TIL’s. Here is a new research article from UCLA and Dr. Ribas, where they are developing a new twist to TIL’s and hopefully in the near future it will be available for those who fail Immunotherapy or targeted therapy or maybe even a first line treatment approach one day. https://cancer.ucla.edu/Home/Components/News/News/1442/1631
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