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Does Ipi cause tumors to get larger and hurt??
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Does Ipi cause tumors to get larger and hurt??

› Forums › Cutaneous Melanoma Community › Does Ipi cause tumors to get larger and hurt??

  • Post
    • November 3, 2010 at 1:28 am
    jolainajo
    Participant

      Hi everyone, I started my trial with Ipi, no temodor though, on Friday the 29th. Yesterday and today I am noticing my subcutaneous tumors which are large are getting larger and very very soar sometimes throbbing and hot. Is this normal?? Other side effects are just tired, Has anyone else had this?? Need some answers.. Thanks… Jolaina, Michigan

      Hi everyone, I started my trial with Ipi, no temodor though, on Friday the 29th. Yesterday and today I am noticing my subcutaneous tumors which are large are getting larger and very very soar sometimes throbbing and hot. Is this normal?? Other side effects are just tired, Has anyone else had this?? Need some answers.. Thanks… Jolaina, Michigan

    Viewing 7 reply threads
    • Replies
        • November 3, 2010 at 3:48 am
        Jim in Denver
        Participant

          Hi Jolaina,

          What you are experienceing is not unusual with Ipi.  Tumors often show an initial inflammatory response (get larger), and the surface ones become more sensitive as well as somewhat enlarged.  The list of potential side effects includes fatigue, diarrhia, rashes and itching.  These side effects can change over time and become either more or less noticable.  Hope that helps a little.

          Best Wishes,

          Jim

          • November 3, 2010 at 3:48 am
          Jim in Denver
          Participant

            Hi Jolaina,

            What you are experienceing is not unusual with Ipi.  Tumors often show an initial inflammatory response (get larger), and the surface ones become more sensitive as well as somewhat enlarged.  The list of potential side effects includes fatigue, diarrhia, rashes and itching.  These side effects can change over time and become either more or less noticable.  Hope that helps a little.

            Best Wishes,

            Jim

            • November 3, 2010 at 12:07 pm
            jim Breitfeller
            Participant

              Jolaina,

              That is a great sign!!!!!  Your Immune  system is recieving the "DANGER SIGNAL"  an Inflammed response!!!! This means your T-cells are activated and trafficing to the tumor bed.  The TILs  are invading the tumor's microenviroment which is making the tumors appear to be larger. You are in the first innings of a full fledge immune response.

              Congrats!  Shrinkage will soon come. It takes time to build an army of T-cells.

              • November 3, 2010 at 12:07 pm
              jim Breitfeller
              Participant

                Jolaina,

                That is a great sign!!!!!  Your Immune  system is recieving the "DANGER SIGNAL"  an Inflammed response!!!! This means your T-cells are activated and trafficing to the tumor bed.  The TILs  are invading the tumor's microenviroment which is making the tumors appear to be larger. You are in the first innings of a full fledge immune response.

                Congrats!  Shrinkage will soon come. It takes time to build an army of T-cells.

                • November 3, 2010 at 2:08 pm
                stillhopeful
                Participant

                  I had the same side effect after the first infusion.  This is best discussed with your doctor.  While it is an indicator that something is happening, it does not necessarily mean that your tumors will shrink.  My week 12 scans showed some growth despite this and several other side effects.  Sorry.  I hesitated in writing this, but you said you wanted some answers.  

                    • November 3, 2010 at 3:55 pm
                    jim Breitfeller
                    Participant

                      It is possible that the tumors and the Tregs can secrete supressive cytokines (IL-10, TGF-b,etc.) to shut down the response. That is why it is helpful get a dose of IL-2 to keep the CTLs functioning and for survival.

                      • November 3, 2010 at 3:55 pm
                      jim Breitfeller
                      Participant

                        It is possible that the tumors and the Tregs can secrete supressive cytokines (IL-10, TGF-b,etc.) to shut down the response. That is why it is helpful get a dose of IL-2 to keep the CTLs functioning and for survival.

                      • November 3, 2010 at 2:08 pm
                      stillhopeful
                      Participant

                        I had the same side effect after the first infusion.  This is best discussed with your doctor.  While it is an indicator that something is happening, it does not necessarily mean that your tumors will shrink.  My week 12 scans showed some growth despite this and several other side effects.  Sorry.  I hesitated in writing this, but you said you wanted some answers.  

                        • November 4, 2010 at 11:49 am
                        jim Breitfeller
                        Participant

                          • November 4, 2010 at 11:49 am
                          jim Breitfeller
                          Participant

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