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Dabrafenib/Tramentinib Trial for Stage IIIA/B/C
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Dabrafenib/Tramentinib Trial for Stage IIIA/B/C

› Forums › Cutaneous Melanoma Community › Dabrafenib/Tramentinib Trial for Stage IIIA/B/C

  • Post
    • March 15, 2014 at 2:02 pm
    Linny
    Participant

      This looks like a good trial for Stage III patients. You may want to ask your doctor about this one!

       

      A Study of the BRAF Inhibitor Dabrafenib in Combination With the MEK Inhibitor Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma After Surgical Resection. (COMBI-AD)

      This is a two-arm, randomized, double-blind Phase III study of dabrafenib in combination with trametinib versus two placebos in the treatment of melanoma after removal by surgery. Patients with BRAF V600E/K mutation-positive cutaneous melanoma that has been completely removed by surgery but who are at high-risk for recurrence [Stage IIIa (lymph node metastasis >1 mm), IIIb or IIIc] may be eligible. Subjects will be randomized to receive either dabrafenib (150 mg twice daily) and trametinib (2 mg once daily) combination therapy or two placebos for 12 months

      http://clinicaltrials.gov/ct2/show/NCT01682083

    Viewing 2 reply threads
    • Replies
        • March 15, 2014 at 4:47 pm
        Cooper
        Participant

          Double blind and placebo would count me out..

            • May 14, 2014 at 3:07 am
            Sheepsandcows
            Participant

              Should someone chose not to participate in the trial, Is there a cancer center in USA where they are using these drugs for dx IIIC and NED after lymph nodes surgery?ba friend was just offered this option and she wants out for the same reason

              thank you

              • May 14, 2014 at 3:07 am
              Sheepsandcows
              Participant

                Should someone chose not to participate in the trial, Is there a cancer center in USA where they are using these drugs for dx IIIC and NED after lymph nodes surgery?ba friend was just offered this option and she wants out for the same reason

                thank you

                • May 14, 2014 at 3:07 am
                Sheepsandcows
                Participant

                  Should someone chose not to participate in the trial, Is there a cancer center in USA where they are using these drugs for dx IIIC and NED after lymph nodes surgery?ba friend was just offered this option and she wants out for the same reason

                  thank you

                • March 15, 2014 at 4:47 pm
                Cooper
                Participant

                  Double blind and placebo would count me out..

                  • March 15, 2014 at 4:47 pm
                  Cooper
                  Participant

                    Double blind and placebo would count me out..

                Viewing 2 reply threads

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