› Forums › General Melanoma Community › Could we get faster approvalsif we had four legs?
- This topic has 15 replies, 3 voices, and was last updated 9 years, 5 months ago by
JerryfromFauq.
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- November 23, 2014 at 7:36 pm
Melanoma Vaccine has been approved for Dogs, now it lookes like one is coming for horses as well.
http://www.abcactionnews.com/news/health/morphogenesis-announces-usda-sanctioned-trial-of-promising-equine-vaccine-is-underway?autoplay=true
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- November 23, 2014 at 7:42 pm
Morphogenesis announces USDA-sanctioned trial of promising equine vaccine
Human implications of equine cancer vaccine
Linda Hurtado3:53 PM, Nov 21, 20145:54 PM, Nov 21, 2014“The way it works is we are educating the immune system,” research scientist Meghan Gentilini said. “So we're putting something into the tumor cells that tells the body this is foreign. Therefore it's specific. It goes to those tumor cells, attacks them and leaves other cells unaffected."Pat Lawman, co-founder and CEO of Morphogenesis, says, “We've treated over 20 different types of cancer now, in cats, dogs and horses, and we’ve treated about 60 different breeds of animals as well."ImmuneFx is being used right now in a USDA-sanctioned clinical trial involving horses with melanoma.Expected to last a year, the trial’s goal is to show the safety of the vaccine in horses like Isabo. Meghan says Isabo, "had a perianal mass and melanoma on her tail. Benny had lesions on his side, however melanoma can be in the perianal area as well. Isbo received our vaccine as well. Her tumors are shrinking and coming to a manageable point to where it’s stable.
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- November 23, 2014 at 7:42 pm
Morphogenesis announces USDA-sanctioned trial of promising equine vaccine
Human implications of equine cancer vaccine
Linda Hurtado3:53 PM, Nov 21, 20145:54 PM, Nov 21, 2014“The way it works is we are educating the immune system,” research scientist Meghan Gentilini said. “So we're putting something into the tumor cells that tells the body this is foreign. Therefore it's specific. It goes to those tumor cells, attacks them and leaves other cells unaffected."Pat Lawman, co-founder and CEO of Morphogenesis, says, “We've treated over 20 different types of cancer now, in cats, dogs and horses, and we’ve treated about 60 different breeds of animals as well."ImmuneFx is being used right now in a USDA-sanctioned clinical trial involving horses with melanoma.Expected to last a year, the trial’s goal is to show the safety of the vaccine in horses like Isabo. Meghan says Isabo, "had a perianal mass and melanoma on her tail. Benny had lesions on his side, however melanoma can be in the perianal area as well. Isbo received our vaccine as well. Her tumors are shrinking and coming to a manageable point to where it’s stable.
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- November 23, 2014 at 7:42 pm
Morphogenesis announces USDA-sanctioned trial of promising equine vaccine
Human implications of equine cancer vaccine
Linda Hurtado3:53 PM, Nov 21, 20145:54 PM, Nov 21, 2014“The way it works is we are educating the immune system,” research scientist Meghan Gentilini said. “So we're putting something into the tumor cells that tells the body this is foreign. Therefore it's specific. It goes to those tumor cells, attacks them and leaves other cells unaffected."Pat Lawman, co-founder and CEO of Morphogenesis, says, “We've treated over 20 different types of cancer now, in cats, dogs and horses, and we’ve treated about 60 different breeds of animals as well."ImmuneFx is being used right now in a USDA-sanctioned clinical trial involving horses with melanoma.Expected to last a year, the trial’s goal is to show the safety of the vaccine in horses like Isabo. Meghan says Isabo, "had a perianal mass and melanoma on her tail. Benny had lesions on his side, however melanoma can be in the perianal area as well. Isbo received our vaccine as well. Her tumors are shrinking and coming to a manageable point to where it’s stable.
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- November 24, 2014 at 8:42 am
Sometimes it's a species thing. Human vaccines are based on the same theories used for the canine and equine vaccine. Unfortunately they haven't worked out as well for humans. Thus you can't just vaccinate with the dog or horse version.
Melanoma in dogs is usually bengin unless oral / occular mel. In cats and horses, deadly. There is enough species vairation in immune systems among other things that make it not as easy to just take what works in one species and apply it to another.
I did see metastatic mel in a steer once. Cause of death was to become guest of honor at his own dinner. Needless to say he wasn't eaten once opened up.
Example of immune differnences – in dogs, allergic reactions tend to be cardiovascular (anaphalaxis) where in cats the same reaction affects the lungs leading to more of an acute asthma attack. Go figure.
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- November 25, 2014 at 11:49 am
Hi Kim, Have you followed the story of the Oncept vaccine?
In 2007, Merial released their melanoma vaccine (Oncept) for the prevention of spread of melanoma to the lungs and lymph nodes in dogs with stage 2 and stage 3 melanoma. The Merial melanoma vaccine for dogs consists of DNA encoding the gene for the human melanocyte protein tyrosinase.
Iniatially the treatment was being developed for humans when the Canine Lab asked thye human researchers if they had anything that they could try on a dog. I'm not sure exactly what changes they nade to the one being developed for people, but what they administered to doogs was USDA approved in 2010. The Human version is still in the standard climical trial route for humans.
http://www.cliniciansbrief.com/sites/default/files/attachments/Canine%20Melanoma%20Vaccine.pdf
(Remember at the sstart many of the human treatments have only added, o n average a coouple of months of life to people. Of course some people are still NED that thried the anti-CTLA-4 treaatment in 2009. (Now named YERVOY.)
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- November 25, 2014 at 11:49 am
Hi Kim, Have you followed the story of the Oncept vaccine?
In 2007, Merial released their melanoma vaccine (Oncept) for the prevention of spread of melanoma to the lungs and lymph nodes in dogs with stage 2 and stage 3 melanoma. The Merial melanoma vaccine for dogs consists of DNA encoding the gene for the human melanocyte protein tyrosinase.
Iniatially the treatment was being developed for humans when the Canine Lab asked thye human researchers if they had anything that they could try on a dog. I'm not sure exactly what changes they nade to the one being developed for people, but what they administered to doogs was USDA approved in 2010. The Human version is still in the standard climical trial route for humans.
http://www.cliniciansbrief.com/sites/default/files/attachments/Canine%20Melanoma%20Vaccine.pdf
(Remember at the sstart many of the human treatments have only added, o n average a coouple of months of life to people. Of course some people are still NED that thried the anti-CTLA-4 treaatment in 2009. (Now named YERVOY.)
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- November 25, 2014 at 11:49 am
Hi Kim, Have you followed the story of the Oncept vaccine?
In 2007, Merial released their melanoma vaccine (Oncept) for the prevention of spread of melanoma to the lungs and lymph nodes in dogs with stage 2 and stage 3 melanoma. The Merial melanoma vaccine for dogs consists of DNA encoding the gene for the human melanocyte protein tyrosinase.
Iniatially the treatment was being developed for humans when the Canine Lab asked thye human researchers if they had anything that they could try on a dog. I'm not sure exactly what changes they nade to the one being developed for people, but what they administered to doogs was USDA approved in 2010. The Human version is still in the standard climical trial route for humans.
http://www.cliniciansbrief.com/sites/default/files/attachments/Canine%20Melanoma%20Vaccine.pdf
(Remember at the sstart many of the human treatments have only added, o n average a coouple of months of life to people. Of course some people are still NED that thried the anti-CTLA-4 treaatment in 2009. (Now named YERVOY.)
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- November 24, 2014 at 8:42 am
Sometimes it's a species thing. Human vaccines are based on the same theories used for the canine and equine vaccine. Unfortunately they haven't worked out as well for humans. Thus you can't just vaccinate with the dog or horse version.
Melanoma in dogs is usually bengin unless oral / occular mel. In cats and horses, deadly. There is enough species vairation in immune systems among other things that make it not as easy to just take what works in one species and apply it to another.
I did see metastatic mel in a steer once. Cause of death was to become guest of honor at his own dinner. Needless to say he wasn't eaten once opened up.
Example of immune differnences – in dogs, allergic reactions tend to be cardiovascular (anaphalaxis) where in cats the same reaction affects the lungs leading to more of an acute asthma attack. Go figure.
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- November 24, 2014 at 8:42 am
Sometimes it's a species thing. Human vaccines are based on the same theories used for the canine and equine vaccine. Unfortunately they haven't worked out as well for humans. Thus you can't just vaccinate with the dog or horse version.
Melanoma in dogs is usually bengin unless oral / occular mel. In cats and horses, deadly. There is enough species vairation in immune systems among other things that make it not as easy to just take what works in one species and apply it to another.
I did see metastatic mel in a steer once. Cause of death was to become guest of honor at his own dinner. Needless to say he wasn't eaten once opened up.
Example of immune differnences – in dogs, allergic reactions tend to be cardiovascular (anaphalaxis) where in cats the same reaction affects the lungs leading to more of an acute asthma attack. Go figure.
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