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Confused by path report: In Situ and Invasive Mel in same lesion?

Forums Cutaneous Melanoma Community Confused by path report: In Situ and Invasive Mel in same lesion?

  • Post
    MeganD
    Participant
      Hi all –

      I am confused by my recent path report which I read after leaving the Dr.’s office, so I could not ask him. Source of my confusion is in bold, the reset is included for context.

      Diagnosis:  INVASIVE MELANOMA, BRESLOW THICKNESS 0.3, NON-ULCERATED (0 mitosis)

      NOTE: Sox-10 highlights an asymmetric compound melanocytic proliferation comprised of single and nested melanocytes in disarray along the dermal-epidermal junction and similar melanocytes in the superficial dermis. PRAME shows strong, uniform positivity throughout the lesional melanocytes, There are a few smaller melanocytes scattered in the dermis lacking PRAME reactivity which are interpreted as an associated melanocytic nevus, These finding support the diagnosis.

      Margins, peripheral and deep: melanoma in situ present at peripheral biopsy margin; deep biopsy margin narrowly free of melanoma.

      So, this lesion was both invasive and in situ? Or, is there additional in situ that goes outside the edges of the biopsy?

      I appreciate any insights you all might have in interpreting this.

      Thanks much.

      Megan

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