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- May 31, 2011 at 11:26 pm
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T Cell Transfer Immunotherapy
Clin Cancer Res.
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T Cell Transfer Immunotherapy
Clin Cancer Res. 2011 Apr 15;[Epub Ahead of Print], SA Rosenberg, JC Yang, RM Sherry, US Kammula, MS Hughes, GQ Phan, DE Citrin, NP Restifo, PF Robbins, JR Wunderlich, KE Morton, CM Laurencot, SM Steinberg, DE White, ME Dudley
Currently available and experimental therapies for metastatic melanoma produce very few durable complete responses and, thus, a low chance of cure. Rosenberg et al from the National Cancer Institute report results of a new approach for these patients: the adoptive transfer of autologous tumor-infiltrating lymphocytes (TILs) selected for antitumor activity and expanded in vitro. The study involved 93 patients with metastatic melanoma who were heavily pretreated with standard and experimental regimens….
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