Combining drugs to treat melanoma
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Combining drugs to treat melanoma

› Forums › General Melanoma Community › Combining drugs to treat melanoma

  • Post
    • September 26, 2015 at 2:36 pm
    Bubbles
    Participant

    For you all:

    I put this post together and thought it might be helpful to some of you.  It includes a webinar with slides presented by Jeffrey Weber and Sanjiv Argwala about data attained from combination therapies (both targeted and immuntherapies) vs results when used alone, side effects, why they work better together, and possible ways to choose the best therapy for the patient.  While none of it is really "new" it does put things together in a fairly concise, understandable manner.  I listed what were some of the salient points to me, if you don't have time for the hour long video.

    http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/09/pick-your-poison-weber-and-agarwala.html

    While nothing is written in stone….we've come a long way baby!!!  Thanks again for the link, Steven.  I wish you all my best.  Celeste

Viewing 14 reply threads
  • Replies
      • September 26, 2015 at 8:45 pm
      Polymath
      Participant

      Celeste,

      Thanks for this helpful summary

      Aloha, Gary

      • September 26, 2015 at 8:45 pm
      Polymath
      Participant

      Celeste,

      Thanks for this helpful summary

      Aloha, Gary

      • September 26, 2015 at 8:45 pm
      Polymath
      Participant

      Celeste,

      Thanks for this helpful summary

      Aloha, Gary

      • September 27, 2015 at 1:16 am
      BrianP
      Participant

      Awesome Cliff notes Celeste.  Reminds me of how I got through college. 🙂 

      Brian

      • September 27, 2015 at 1:16 am
      BrianP
      Participant

      Awesome Cliff notes Celeste.  Reminds me of how I got through college. 🙂 

      Brian

      • September 27, 2015 at 1:16 am
      BrianP
      Participant

      Awesome Cliff notes Celeste.  Reminds me of how I got through college. 🙂 

      Brian

      • September 27, 2015 at 9:19 pm
      Rita and Charles
      Participant

      Hi Celeste, 

      My husband has been on this combo for about 2 3/4 months. The first CT Scan was really positive – 50% reduction in the lung tumor and  lymph node activity has regressed.  BUT a few weeks ago, his vision in his left eye was impacted. His opthamologist ran tests and he has developed Iritus as a result of the BRAF combo side effect – very rare, but he has it!  Now, to heal the eye he needs to stop the combo…………..should we be scared out of our minds? His vison vs. more growth?

       

      Rita

      • September 27, 2015 at 9:19 pm
      Rita and Charles
      Participant

      Hi Celeste, 

      My husband has been on this combo for about 2 3/4 months. The first CT Scan was really positive – 50% reduction in the lung tumor and  lymph node activity has regressed.  BUT a few weeks ago, his vision in his left eye was impacted. His opthamologist ran tests and he has developed Iritus as a result of the BRAF combo side effect – very rare, but he has it!  Now, to heal the eye he needs to stop the combo…………..should we be scared out of our minds? His vison vs. more growth?

       

      Rita

        • September 28, 2015 at 1:27 am
        Bubbles
        Participant

        Hi Rita,

        Sorry you and your husband are suffering with that.  It sounds as though with a break in treatment and possibly steriods (or whatever treatment the oncs and ophthmologists deem appropriate), from the info reported…especially if you look at the post I made about treating side effects….they should hopefully be able to get your husband's vision under control.  Then, when you think about what the docs said regarding choosing treatment….with his reduction in tumor burden, it sounds a s though your husband would be a candidate to now move to an anti-PD1 product or to the ipi/nivo combo.  Some folks have been advocating use of the BRAF/MEK combo in that way from the start…regardless of side effects.  Hit the melanoma hard, get some tumor reduction quickly, then switch to immunotherapy.  I don't presume to know your husband's case and condition enough to say for certain…but that is what I would certainly be asking about.  I wish you both my best. C

        • September 28, 2015 at 1:27 am
        Bubbles
        Participant

        Hi Rita,

        Sorry you and your husband are suffering with that.  It sounds as though with a break in treatment and possibly steriods (or whatever treatment the oncs and ophthmologists deem appropriate), from the info reported…especially if you look at the post I made about treating side effects….they should hopefully be able to get your husband's vision under control.  Then, when you think about what the docs said regarding choosing treatment….with his reduction in tumor burden, it sounds a s though your husband would be a candidate to now move to an anti-PD1 product or to the ipi/nivo combo.  Some folks have been advocating use of the BRAF/MEK combo in that way from the start…regardless of side effects.  Hit the melanoma hard, get some tumor reduction quickly, then switch to immunotherapy.  I don't presume to know your husband's case and condition enough to say for certain…but that is what I would certainly be asking about.  I wish you both my best. C

        • September 28, 2015 at 1:27 am
        Bubbles
        Participant

        Hi Rita,

        Sorry you and your husband are suffering with that.  It sounds as though with a break in treatment and possibly steriods (or whatever treatment the oncs and ophthmologists deem appropriate), from the info reported…especially if you look at the post I made about treating side effects….they should hopefully be able to get your husband's vision under control.  Then, when you think about what the docs said regarding choosing treatment….with his reduction in tumor burden, it sounds a s though your husband would be a candidate to now move to an anti-PD1 product or to the ipi/nivo combo.  Some folks have been advocating use of the BRAF/MEK combo in that way from the start…regardless of side effects.  Hit the melanoma hard, get some tumor reduction quickly, then switch to immunotherapy.  I don't presume to know your husband's case and condition enough to say for certain…but that is what I would certainly be asking about.  I wish you both my best. C

      • September 27, 2015 at 9:19 pm
      Rita and Charles
      Participant

      Hi Celeste, 

      My husband has been on this combo for about 2 3/4 months. The first CT Scan was really positive – 50% reduction in the lung tumor and  lymph node activity has regressed.  BUT a few weeks ago, his vision in his left eye was impacted. His opthamologist ran tests and he has developed Iritus as a result of the BRAF combo side effect – very rare, but he has it!  Now, to heal the eye he needs to stop the combo…………..should we be scared out of our minds? His vison vs. more growth?

       

      Rita

      • September 28, 2015 at 1:41 am
      JoshF
      Participant

      Celeste-

      thanks for posting…always great info. You're truly a gift to all of us in this forum.

      Josh

      • September 28, 2015 at 1:41 am
      JoshF
      Participant

      Celeste-

      thanks for posting…always great info. You're truly a gift to all of us in this forum.

      Josh

      • September 28, 2015 at 1:41 am
      JoshF
      Participant

      Celeste-

      thanks for posting…always great info. You're truly a gift to all of us in this forum.

      Josh

        • September 28, 2015 at 2:31 am
        Bubbles
        Participant

        Thanks to all my boys.  I appreciate your kind words, Josh.  But…there's an ANON out there…who may well disagree with you!!!  I'm sure you can imagine how much that hurts my heart.  Love to you all.  c

        • September 28, 2015 at 2:31 am
        Bubbles
        Participant

        Thanks to all my boys.  I appreciate your kind words, Josh.  But…there's an ANON out there…who may well disagree with you!!!  I'm sure you can imagine how much that hurts my heart.  Love to you all.  c

        • September 28, 2015 at 2:31 am
        Bubbles
        Participant

        Thanks to all my boys.  I appreciate your kind words, Josh.  But…there's an ANON out there…who may well disagree with you!!!  I'm sure you can imagine how much that hurts my heart.  Love to you all.  c

        • September 28, 2015 at 9:37 pm
        JoshF
        Participant

        Well the Anon's don't  do much for me but you're always there to support, provide info or lend advice. I'll stick with you.

        Josh

        • September 28, 2015 at 9:37 pm
        JoshF
        Participant

        Well the Anon's don't  do much for me but you're always there to support, provide info or lend advice. I'll stick with you.

        Josh

        • September 28, 2015 at 9:37 pm
        JoshF
        Participant

        Well the Anon's don't  do much for me but you're always there to support, provide info or lend advice. I'll stick with you.

        Josh

      • September 28, 2015 at 3:43 pm
      dfeng
      Participant

      thanks for sharing.

      • September 28, 2015 at 3:43 pm
      dfeng
      Participant

      thanks for sharing.

      • September 28, 2015 at 3:43 pm
      dfeng
      Participant

      thanks for sharing.

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