› Forums › General Melanoma Community › COMBI – AD trial for stage 3. Any views or experiences?
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oldblue.
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- September 28, 2014 at 4:35 pm
Hi all,
I am a recent diagnosed stage 3b and have been offered this trial. Its 50:50 whether I get the drugs or the sugar pills (placebo). The drugs are the BRAF inhibitor dabrafenib and the MEK inhibitor trametnib.
I had two inguinal lymph nodes positive on SLNB in 07/2014. This was followed up by one positive lymph node on the complete lymph removal from my L groin in August.
They say this may 'mop up' any cells still in my body. Every oncologist or surgeon or trial professor has used the term 'mop up.' This apparently is the first time this drugs have been used for stage 3.
Is anyone on this trial – its multi centre – or does anyone have any views or expereinces of it?
I'd be grateful for anything you wish to share.
Thank you in advance.
Nigel.
PS I'm being treated in Sydney, Australia.
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- September 28, 2014 at 7:51 pm
Hey Nigel,
Here's a mishmash of stuff on the topic..
Out of ASCO, June 2014:
Updated overall survival for BRF113220, a phase 1-2 study of dabrafenib alone versus combined dabrafenib and trametinib in patients with BRAF V600 positive metastatic melanoma
Abstract 9010, ASCO
Flaherty, Daud, Weber, Sosman, et alBRAF V600E/K positive, metastatic melanoma patients who had never taken either drug were enrolled. Some were given dabrafenib alone and others the dabrafenib and trametinib combo…both at various dosage rates. Cross over after progression on dabrafenib alone was allowed. Updated data shows overall survival at 18 months for dabrafenib alone = 56%, for the combo =67%.
Here is a link to some general info about BRAF….particulars about the DT combo are at the bottom of the post: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html
Here's a post I put up when the combo was FDA approved: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/01/dabrafenibtrametinib-brafmek-combo.html
And here is what might be most applicable to your situation….the first article from a post I just put up…
Hope that some of that may help! Yours, Celeste
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- September 28, 2014 at 7:51 pm
Hey Nigel,
Here's a mishmash of stuff on the topic..
Out of ASCO, June 2014:
Updated overall survival for BRF113220, a phase 1-2 study of dabrafenib alone versus combined dabrafenib and trametinib in patients with BRAF V600 positive metastatic melanoma
Abstract 9010, ASCO
Flaherty, Daud, Weber, Sosman, et alBRAF V600E/K positive, metastatic melanoma patients who had never taken either drug were enrolled. Some were given dabrafenib alone and others the dabrafenib and trametinib combo…both at various dosage rates. Cross over after progression on dabrafenib alone was allowed. Updated data shows overall survival at 18 months for dabrafenib alone = 56%, for the combo =67%.
Here is a link to some general info about BRAF….particulars about the DT combo are at the bottom of the post: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html
Here's a post I put up when the combo was FDA approved: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/01/dabrafenibtrametinib-brafmek-combo.html
And here is what might be most applicable to your situation….the first article from a post I just put up…
Hope that some of that may help! Yours, Celeste
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- September 28, 2014 at 7:51 pm
Hey Nigel,
Here's a mishmash of stuff on the topic..
Out of ASCO, June 2014:
Updated overall survival for BRF113220, a phase 1-2 study of dabrafenib alone versus combined dabrafenib and trametinib in patients with BRAF V600 positive metastatic melanoma
Abstract 9010, ASCO
Flaherty, Daud, Weber, Sosman, et alBRAF V600E/K positive, metastatic melanoma patients who had never taken either drug were enrolled. Some were given dabrafenib alone and others the dabrafenib and trametinib combo…both at various dosage rates. Cross over after progression on dabrafenib alone was allowed. Updated data shows overall survival at 18 months for dabrafenib alone = 56%, for the combo =67%.
Here is a link to some general info about BRAF….particulars about the DT combo are at the bottom of the post: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/braf-inhibitors-for-melanoma-dabrafenib.html
Here's a post I put up when the combo was FDA approved: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/01/dabrafenibtrametinib-brafmek-combo.html
And here is what might be most applicable to your situation….the first article from a post I just put up…
Hope that some of that may help! Yours, Celeste
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