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Cobimetinib and Vemurafenib combo

Forums Cutaneous Melanoma Community Cobimetinib and Vemurafenib combo

  • Post
    jrtufo
    Participant

    Hi Caring Friends-So the Keytruda didn't work for me and now I'm moving on to the Cobimetinib/Vemurafenib combo.  Living here in sunny Colorado I'm very concerned about the photo sensitivity side effect (and all of the others…)  Any one on this combo-how is it going, any success and any tips for me?

    Julie T stage 3C non-resectable desmoplastic melanoma 

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      Bubbles
      Participant

      Hi Julie, 

      This combo has served many well!  Here are some reports:  https://chaoticallypreciselifeloveandmelanoma.blogspot.com/search?q=cobimetinib  

      Side effects seem to be pretty typical for what is expected for all BRAF/MEK combo's. And that certainly includes sun protection.  Perhaps others with direct experience will chime in, but you can do this!  Hope this helps!  Celeste

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        jrtufo
        Participant

        Thanks so much-I've seen a few of these but not all, so lots to process.  Now I'm off for some guiltless spf-protected clothes shopping:)

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        Pcarpent
        Participant

        Julie, I hope the combo is working. My husband has been on it since last July and seems to be working. I am trying to find someone on this combo to ask a few questions. My husband seems to get more nauseated and fatigued the closer he gets to the end of his Cotellic dose, closer to the 21st day. Do you or anyone else notice this? Thanks so much for your thoughts. Pamela

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        Sylvia0912
        Participant

        That's how it works. It's true what you've mentioned. My best friend is taking it since oct.2016 with ups and downs. Tell your husband there is not a chance to take sunlight. He'll probably need a parallel therapy in case he is having a rash or any other side effect. All the best, Sylvia

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