Can you be a BRAF K and “the Wild Type?”

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Can you be a BRAF K and “the Wild Type?”

This topic has 3 replies, 1 voice, and was last updated 11 years, 3 months ago by POW.

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- January 22, 2013 at 2:42 pm
- Quote
mrsmarilyn
Participant
My brother received his results from his BRAF testing out of USF – and it states "braf K – "the wild type". How can he be both K and the wild type. I thought K was a mutated gene – and wild is not mutated. Right now he is on yervoy – but needs to know his options – just in case yervoy fails.

Thanks very much-

MrsMarilyn

Sister of Gary'

(Stage IV for 11 years now!)

My brother received his results from his BRAF testing out of USF – and it states "braf K – "the wild type". How can he be both K and the wild type. I thought K was a mutated gene – and wild is not mutated. Right now he is on yervoy – but needs to know his options – just in case yervoy fails.

Thanks very much-

MrsMarilyn

Sister of Gary'

(Stage IV for 11 years now!)

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- - January 22, 2013 at 4:29 pm
  - Quote
  POW
  Participant
  "V600E" means that in the BRAF protein, the normal (wild type) valine (V) at amino acid position 600 has been replaced with a glycine (E), which is a mutation. V600K means that the wild type valine at position 600 has been replaced with a lysine (K), which is also a mutation. BRAF V600E and V600K both respond to Zelboraf. I suggest that you ask your doctor to clarify what is going on here.
- - January 22, 2013 at 4:29 pm
  - Quote
  POW
  Participant
  "V600E" means that in the BRAF protein, the normal (wild type) valine (V) at amino acid position 600 has been replaced with a glycine (E), which is a mutation. V600K means that the wild type valine at position 600 has been replaced with a lysine (K), which is also a mutation. BRAF V600E and V600K both respond to Zelboraf. I suggest that you ask your doctor to clarify what is going on here.
- - January 22, 2013 at 4:29 pm
  - Quote
  POW
  Participant
  "V600E" means that in the BRAF protein, the normal (wild type) valine (V) at amino acid position 600 has been replaced with a glycine (E), which is a mutation. V600K means that the wild type valine at position 600 has been replaced with a lysine (K), which is also a mutation. BRAF V600E and V600K both respond to Zelboraf. I suggest that you ask your doctor to clarify what is going on here.

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