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Calling All Irish Ancestry Wild Type BRAF
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Calling All Irish Ancestry Wild Type BRAF

› Forums › General Melanoma Community › Calling All Irish Ancestry Wild Type BRAF

  • Post
    • April 8, 2013 at 9:50 am
    buffcody
    Participant

      You will find a link on the site below to a most interesting article about the relative rarity of the BRAF mutation among the Irish, while there are other melanoma-linked mutations more common to us folk.  I'm 7/8 Irish ancestry myself and BRAF-negative. 

      http://www.newswise.com/institutions/newsroom/2818/

      You will find a link on the site below to a most interesting article about the relative rarity of the BRAF mutation among the Irish, while there are other melanoma-linked mutations more common to us folk.  I'm 7/8 Irish ancestry myself and BRAF-negative. 

      http://www.newswise.com/institutions/newsroom/2818/

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    • Replies
        • April 8, 2013 at 12:24 pm
        john partrick michael murphy
        Participant
          How lucky can a fellow get? My father, 100% Irish, met my mother on a ship in 1928, and fell in love with the red headed beauty from Germany.
          I am a stage IVb who is BRAF positive, and responding well to the inhibitors, and very thankful she turned his head and heart.
            • April 9, 2013 at 8:45 pm
            lou2
            Participant

              Here is the direct link to the article:   http://tiny.cc/ffjavw

              The thing about Irish in countries other than Ireland, such as the U.S., is that there is a lot of mixing.  Certainly after one generation, hardly any of us are pure Irish.  I am wondering how it works with different groups of Irish, since the celtic people in the British isles were repeatedly invaded by vikings.  That influence was clear in my Irish ancestors.  And on top of that, the celts originally came from Europe.  So, was this study really able to make such a definite statement about the smaller number of braf mutations in Ireland?  The study only included 150 people total from two countries.

              • April 9, 2013 at 11:48 pm
              buffcody
              Participant

                I agree with your hesitations  about the study entirely.  However, MAYBE, the fact that the Irish are not 100% NRAS is due to all that mixing with the original Celts, if they were indeed the originals.wink At least there seems to have been a significant difference in BRAF and NRAS propensity despite the small size  of the study.   I happen to be reading a history of Ireland and there were not only Vikings but Danes and Scots and Normans and English in the mix. 

                • April 9, 2013 at 11:48 pm
                buffcody
                Participant

                  I agree with your hesitations  about the study entirely.  However, MAYBE, the fact that the Irish are not 100% NRAS is due to all that mixing with the original Celts, if they were indeed the originals.wink At least there seems to have been a significant difference in BRAF and NRAS propensity despite the small size  of the study.   I happen to be reading a history of Ireland and there were not only Vikings but Danes and Scots and Normans and English in the mix. 

                  • April 9, 2013 at 11:48 pm
                  buffcody
                  Participant

                    I agree with your hesitations  about the study entirely.  However, MAYBE, the fact that the Irish are not 100% NRAS is due to all that mixing with the original Celts, if they were indeed the originals.wink At least there seems to have been a significant difference in BRAF and NRAS propensity despite the small size  of the study.   I happen to be reading a history of Ireland and there were not only Vikings but Danes and Scots and Normans and English in the mix. 

                    • April 9, 2013 at 8:45 pm
                    lou2
                    Participant

                      Here is the direct link to the article:   http://tiny.cc/ffjavw

                      The thing about Irish in countries other than Ireland, such as the U.S., is that there is a lot of mixing.  Certainly after one generation, hardly any of us are pure Irish.  I am wondering how it works with different groups of Irish, since the celtic people in the British isles were repeatedly invaded by vikings.  That influence was clear in my Irish ancestors.  And on top of that, the celts originally came from Europe.  So, was this study really able to make such a definite statement about the smaller number of braf mutations in Ireland?  The study only included 150 people total from two countries.

                      • April 9, 2013 at 8:45 pm
                      lou2
                      Participant

                        Here is the direct link to the article:   http://tiny.cc/ffjavw

                        The thing about Irish in countries other than Ireland, such as the U.S., is that there is a lot of mixing.  Certainly after one generation, hardly any of us are pure Irish.  I am wondering how it works with different groups of Irish, since the celtic people in the British isles were repeatedly invaded by vikings.  That influence was clear in my Irish ancestors.  And on top of that, the celts originally came from Europe.  So, was this study really able to make such a definite statement about the smaller number of braf mutations in Ireland?  The study only included 150 people total from two countries.

                      • April 8, 2013 at 12:24 pm
                      john partrick michael murphy
                      Participant
                        How lucky can a fellow get? My father, 100% Irish, met my mother on a ship in 1928, and fell in love with the red headed beauty from Germany.
                        I am a stage IVb who is BRAF positive, and responding well to the inhibitors, and very thankful she turned his head and heart.
                        • April 8, 2013 at 12:24 pm
                        john partrick michael murphy
                        Participant
                          How lucky can a fellow get? My father, 100% Irish, met my mother on a ship in 1928, and fell in love with the red headed beauty from Germany.
                          I am a stage IVb who is BRAF positive, and responding well to the inhibitors, and very thankful she turned his head and heart.
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