Brain mets

Hi, each clinical trial is different regarding brain mets, so you'll need to check them.

Regarding yervoy and the other immunotherapies, they all pass the blood brain barrier and so if they work for you,  they could work on brain mets.

julie

Hi, each clinical trial is different regarding brain mets, so you'll need to check them.

Regarding yervoy and the other immunotherapies, they all pass the blood brain barrier and so if they work for you,  they could work on brain mets.

julie

Hi, each clinical trial is different regarding brain mets, so you'll need to check them.

Regarding yervoy and the other immunotherapies, they all pass the blood brain barrier and so if they work for you,  they could work on brain mets.

julie

Most trials require that brain mets be under control post surgery or SRS…but it varies.  Here is a post I made when patients with brain met WERE admitted in a new arm of my anti-PD1 (nivo/opdivo) trial – (look toward the bottom…I don't know if all the slots have been filled or not): http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/03/9-months-after-nivolumab-trialstats-fu.html 

Here is a post discussing that very thing….Should patients with melanoma brain mets be allowed in trials?  (The answer is:  YES!!!):  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/03/should-melanoma-brain-met-patients-be.html

Here is a link to a post I have provided many times.  Yes, immunotherapies (ipi and anti-PD1) work in the brain. In fact, many studies are noting that BRAF inhibitors (for BRAF positive patients) work as well.  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/anti-pd1-in-melanoma-t-cells-brain-and.html

Here's an overview:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/overview-of-treatments-for-melanoma.html

And how ipi combined with radiation can be especially effective:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/02/ipi-nivo-combo-and-radiation-for.html

http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/01/ipi-and-radiationa-good-combo-for.html

Hope that helps.  I wish you well.  Celeste

Most trials require that brain mets be under control post surgery or SRS…but it varies.  Here is a post I made when patients with brain met WERE admitted in a new arm of my anti-PD1 (nivo/opdivo) trial – (look toward the bottom…I don't know if all the slots have been filled or not): http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/03/9-months-after-nivolumab-trialstats-fu.html 

Here is a post discussing that very thing….Should patients with melanoma brain mets be allowed in trials?  (The answer is:  YES!!!):  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/03/should-melanoma-brain-met-patients-be.html

Here is a link to a post I have provided many times.  Yes, immunotherapies (ipi and anti-PD1) work in the brain. In fact, many studies are noting that BRAF inhibitors (for BRAF positive patients) work as well.  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/anti-pd1-in-melanoma-t-cells-brain-and.html

Here's an overview:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/overview-of-treatments-for-melanoma.html

And how ipi combined with radiation can be especially effective:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/02/ipi-nivo-combo-and-radiation-for.html

http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/01/ipi-and-radiationa-good-combo-for.html

Hope that helps.  I wish you well.  Celeste

Most trials require that brain mets be under control post surgery or SRS…but it varies.  Here is a post I made when patients with brain met WERE admitted in a new arm of my anti-PD1 (nivo/opdivo) trial – (look toward the bottom…I don't know if all the slots have been filled or not): http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/03/9-months-after-nivolumab-trialstats-fu.html 

Here is a post discussing that very thing….Should patients with melanoma brain mets be allowed in trials?  (The answer is:  YES!!!):  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/03/should-melanoma-brain-met-patients-be.html

Here is a link to a post I have provided many times.  Yes, immunotherapies (ipi and anti-PD1) work in the brain. In fact, many studies are noting that BRAF inhibitors (for BRAF positive patients) work as well.  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/anti-pd1-in-melanoma-t-cells-brain-and.html

Here's an overview:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/02/overview-of-treatments-for-melanoma.html

And how ipi combined with radiation can be especially effective:  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/02/ipi-nivo-combo-and-radiation-for.html

http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/01/ipi-and-radiationa-good-combo-for.html

Hope that helps.  I wish you well.  Celeste

Most studies require that they be treated before hand.  You should be talking to a melanomoa specialist if you have melanoma. It is a tricky disease and a typical cancer doctor is not who you should be seeing.  

My Mother had 25 brain tumors treated with gamma knife radiation. Whole Brain Radiation was never discussed. – I think the doctors felt WBRT was not as beneficial long term compared to gamma knife radiation.

She started Yervoy 4 days after the first gamma knife treatment in December (2013) for 8 of 9 (Doctor in Beverly Hills MISSED 1!) and had her last infusion at the end of March (2014) about 3 weeks before the 2nd gamma knife radiation treatment where 17 were treated at USC in Los Angeles (USC has hands down BEST Doctors!).

It has been mentioned to us that Yervoy seems to work "last" on the brain.  It does pass the blood brain barrier which is why we went with this option.  I do not however know if there is evidence that it works on the brain last or not. However, the tumors my Mom had on her scalp and elsewhere were gone or significantly reduced but she had new growth after treatment with Yervoy in the brain. (Could be because of the screw up by the doctor in Beverly Hills who missed 1 brain tumor.)  I do know that she has had NO no new growth since the 2nd successful treatment by Dr. Chang and his team at USC. 

Since we discovered my Mom had brain cancer she had been taking  Cibdex, it is a natural source of cannabinoids. There is a article below that indicates this can be beneficial for brain cancer with gamma knife radiation. 

Read these studies:

http://www.elekta.com/press/9381f384-ff4a-4561-80c7-5175f5e0f381/study-finds-gamma-knife-radiosurgery-alone-yields-equal-survival-outcomes-for-patients-with-two-to-10-tumors.html

“The essential criticism of employing Gamma Knife radiosurgery without WBRT for patients with several lesions is that microscopic tumors might go untreated, necessitating salvage stereotactic radiosurgery or an alternative therapy,” he adds. “Thus, WBRT is widely advocated. However, a recent study showed that WBRT is only able to prevent the emergence of new tumors for no more than six months post-treatment. Many patients with brain mets can survive for more than a year, thereby outliving the effects of WBRT.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892394/

Study finds marijana drastically shrinks brain cancer

http://www.huffingtonpost.com/2014/11/18/marijuana-brain-cancer_n_6181060.html?ir=Healthy+Living

Most studies require that they be treated before hand.  You should be talking to a melanomoa specialist if you have melanoma. It is a tricky disease and a typical cancer doctor is not who you should be seeing.  

My Mother had 25 brain tumors treated with gamma knife radiation. Whole Brain Radiation was never discussed. – I think the doctors felt WBRT was not as beneficial long term compared to gamma knife radiation.

She started Yervoy 4 days after the first gamma knife treatment in December (2013) for 8 of 9 (Doctor in Beverly Hills MISSED 1!) and had her last infusion at the end of March (2014) about 3 weeks before the 2nd gamma knife radiation treatment where 17 were treated at USC in Los Angeles (USC has hands down BEST Doctors!).

It has been mentioned to us that Yervoy seems to work "last" on the brain.  It does pass the blood brain barrier which is why we went with this option.  I do not however know if there is evidence that it works on the brain last or not. However, the tumors my Mom had on her scalp and elsewhere were gone or significantly reduced but she had new growth after treatment with Yervoy in the brain. (Could be because of the screw up by the doctor in Beverly Hills who missed 1 brain tumor.)  I do know that she has had NO no new growth since the 2nd successful treatment by Dr. Chang and his team at USC. 

Since we discovered my Mom had brain cancer she had been taking  Cibdex, it is a natural source of cannabinoids. There is a article below that indicates this can be beneficial for brain cancer with gamma knife radiation. 

Read these studies:

http://www.elekta.com/press/9381f384-ff4a-4561-80c7-5175f5e0f381/study-finds-gamma-knife-radiosurgery-alone-yields-equal-survival-outcomes-for-patients-with-two-to-10-tumors.html

“The essential criticism of employing Gamma Knife radiosurgery without WBRT for patients with several lesions is that microscopic tumors might go untreated, necessitating salvage stereotactic radiosurgery or an alternative therapy,” he adds. “Thus, WBRT is widely advocated. However, a recent study showed that WBRT is only able to prevent the emergence of new tumors for no more than six months post-treatment. Many patients with brain mets can survive for more than a year, thereby outliving the effects of WBRT.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892394/

Study finds marijana drastically shrinks brain cancer

http://www.huffingtonpost.com/2014/11/18/marijuana-brain-cancer_n_6181060.html?ir=Healthy+Living

Most studies require that they be treated before hand.  You should be talking to a melanomoa specialist if you have melanoma. It is a tricky disease and a typical cancer doctor is not who you should be seeing.  

My Mother had 25 brain tumors treated with gamma knife radiation. Whole Brain Radiation was never discussed. – I think the doctors felt WBRT was not as beneficial long term compared to gamma knife radiation.

She started Yervoy 4 days after the first gamma knife treatment in December (2013) for 8 of 9 (Doctor in Beverly Hills MISSED 1!) and had her last infusion at the end of March (2014) about 3 weeks before the 2nd gamma knife radiation treatment where 17 were treated at USC in Los Angeles (USC has hands down BEST Doctors!).

It has been mentioned to us that Yervoy seems to work "last" on the brain.  It does pass the blood brain barrier which is why we went with this option.  I do not however know if there is evidence that it works on the brain last or not. However, the tumors my Mom had on her scalp and elsewhere were gone or significantly reduced but she had new growth after treatment with Yervoy in the brain. (Could be because of the screw up by the doctor in Beverly Hills who missed 1 brain tumor.)  I do know that she has had NO no new growth since the 2nd successful treatment by Dr. Chang and his team at USC. 

Since we discovered my Mom had brain cancer she had been taking  Cibdex, it is a natural source of cannabinoids. There is a article below that indicates this can be beneficial for brain cancer with gamma knife radiation. 

Read these studies:

http://www.elekta.com/press/9381f384-ff4a-4561-80c7-5175f5e0f381/study-finds-gamma-knife-radiosurgery-alone-yields-equal-survival-outcomes-for-patients-with-two-to-10-tumors.html

“The essential criticism of employing Gamma Knife radiosurgery without WBRT for patients with several lesions is that microscopic tumors might go untreated, necessitating salvage stereotactic radiosurgery or an alternative therapy,” he adds. “Thus, WBRT is widely advocated. However, a recent study showed that WBRT is only able to prevent the emergence of new tumors for no more than six months post-treatment. Many patients with brain mets can survive for more than a year, thereby outliving the effects of WBRT.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892394/

Study finds marijana drastically shrinks brain cancer

http://www.huffingtonpost.com/2014/11/18/marijuana-brain-cancer_n_6181060.html?ir=Healthy+Living